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3D printing skull repair titanium mesh and preparation method thereof

A 3D printing, skull technology, applied in the direction of the skull, bone implants, prostheses, etc., can solve the problem that the titanium mesh cannot be quickly fused with soft tissues, so as to increase surface roughness and biological activity, accelerate repair and healing, and promote adhesion Effect

Active Publication Date: 2022-05-17
ASIA BIOMATERIALS WUHAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The purpose of this application is to provide a 3D printed titanium mesh for skull repair and its preparation method to solve the problem that the finished titanium mesh cannot be rapidly fused with soft tissue at present

Method used

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  • 3D printing skull repair titanium mesh and preparation method thereof
  • 3D printing skull repair titanium mesh and preparation method thereof

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preparation example Construction

[0042] According to an exemplary embodiment of the present invention, there is provided a 3D printed skull repair titanium mesh preparation method, the method comprising:

[0043] S1. Analyze the head to be repaired to obtain information on the location of the skull defect;

[0044] Specifically, a ct scan and enhancement scan of the head defect site is first performed, followed by a three-dimensional reconstruction to determine the location, size, shape, etc. of the head skull defect.

[0045] S2. 3D printing according to the information of the skull defect site to obtain a titanium mesh skull model;

[0046] The scan data is poured into the software for bone defect model design, saved in STL format and imported into the 3D printer, the software is used to correct and calibrate the bone defect model, and the data of the model is shaped using digital equipment to make a titanium mesh that matches the defect site, and the edge of the titanium mesh should exceed the edge of the defe...

Embodiment 1

[0072] Preparation method of 3D printed skull repair titanium mesh, the steps are as follows:

[0073] Preparation of S1, 3D printed titanium mesh. First of all, ct scan and enhanced scanning of the head defect site is carried out, and then three-dimensional reconstruction is carried out to determine the location, size, shape, etc. of the head skull defect; the scanning data is poured into the software for bone defect model design, saved in STL format and imported into the 3D printer, the software is used to correct and calibrate the bone defect model, and the digital equipment is used to shape according to the data of the model, and the titanium mesh matching the defect site is made, and the edge of the titanium mesh should exceed the edge of the defect by 1cm. The chemical composition of the pure titanium restoration conforms to the GB / T 13810-2017 standard of "Titanium and titanium alloy processing materials for surgical implants"; the 3D printed titanium mesh is integrally for...

Embodiment 2

[0078] Preparation method of 3D printed skull repair titanium mesh, the steps are as follows:

[0079]Preparation of S1, 3D printed titanium mesh. First of all, ct scan and enhanced scanning of the head defect site is carried out, and then three-dimensional reconstruction is carried out to determine the location, size, shape, etc. of the head skull defect; the scanning data is poured into the software for bone defect model design, saved in STL format and imported into the 3D printer, the software is used to correct and calibrate the bone defect model, and the digital equipment is used to shape according to the data of the model, and the titanium mesh matching the defect site is made, and the edge of the titanium mesh should exceed the edge of the defect by 1cm. The chemical composition of the pure titanium restoration conforms to the GB / T 13810-2017 "Titanium and titanium alloy processing materials for surgical implants" standard; the 3D printed titanium mesh is integrally formed...

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Abstract

The invention particularly relates to a 3D printing skull repair titanium mesh and a preparation method thereof, and belongs to the technical field of biomedical materials.The method comprises the steps that a to-be-repaired head is analyzed, and skull defect part information is obtained; 3D printing is conducted according to the skull defect part information, and a titanium mesh skull model is obtained; adding the titanium mesh skull model into a dopamine solution to obtain a polydopamine microsphere modified titanium mesh skull model; the method comprises the following steps: dissolving type I collagen in a solvent to obtain a gel solution; mixing hydroxyapatite with the gel solution to obtain the 3D printing bio-ink, 3D printing bio-ink is printed on the poly-dopamine microsphere modified titanium mesh skull model, post-treatment is conducted, and the repaired titanium mesh is obtained. The 3D printing titanium mesh is combined with the hydroxyapatite / collagen guided tissue regeneration layer, so that the surface roughness and biological activity of the titanium mesh material can be improved, the combination of the material and bones is promoted, the adhesion and proliferation of cells are promoted, osteogenesis is induced, and the repair and healing of skull tissues are accelerated.

Description

Technical field [0001] The present invention belongs to the field of biomedical materials technology, particularly relates to a 3D printed skull repair titanium mesh and preparation method thereof. Background [0002] Skull defects are a common secondary disease in the clinic. It is mainly seen in various traumas and postoperative injuries, such as electric shock injuries, car accident injuries, gunshot wounds, skull malignancy resection, congenital malformations, and post-cranial flap decompression surgery. In principle, skull defects with a maximum diameter of more than 3 cm require skull reconstruction surgery, and when the skull defect exceeds 3 cm, clinical symptoms can be produced. Successful skull reconstruction requires three requirements: (1) maintaining the integrity of the dura mater, i.e., the protection of the brain; (2) protection of the barrier between the brain and the outside world, i.e., biomechanical stability; and (3) maintaining the normal dome-like shape of...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/34A61L27/46A61L27/54A61L27/58A61F2/28B33Y30/00B33Y70/00B33Y70/10B33Y80/00
CPCA61F2/2846A61F2/2875A61L27/06A61L27/54A61L27/58B33Y70/10B33Y80/00B33Y70/00B33Y30/00A61L27/46A61L27/34A61L2300/412A61L2300/608A61L2300/112A61L2300/252C08L89/00C08L79/04Y02P10/25
Inventor 唐三王喆周雄
Owner ASIA BIOMATERIALS WUHAN CO LTD
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