Preparation of oral black phosphorus nano material and application of oral black phosphorus nano material in gastrointestinal diseases

A technology for gastrointestinal diseases and nanomaterials, which is applied in the field of preparation and its application in gastrointestinal diseases, can solve the problems of non-compliance, difficulty in making injections, difficulty in maintaining uniformity and stability, and achieve stability and dispersion sex enhancing effect

Pending Publication Date: 2022-05-10
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

The commonly used method of administration is injection administration. However, a series of aqueous solutions of black phosphorus materials are colored, most of which are black, and exist in the form of a suspension, which is difficult to maintain uniformity and stability for a long time. Requirements for injections, it is difficult to make injections, which hinders the development of its development as a drug or preparation to treat major diseases to a certain extent.

Method used

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  • Preparation of oral black phosphorus nano material and application of oral black phosphorus nano material in gastrointestinal diseases
  • Preparation of oral black phosphorus nano material and application of oral black phosphorus nano material in gastrointestinal diseases
  • Preparation of oral black phosphorus nano material and application of oral black phosphorus nano material in gastrointestinal diseases

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preparation example Construction

[0040] The preparation of a kind of oral black phosphorus nanomaterial of the present invention comprises the following steps:

[0041] (1) Take 3-6mg of black phosphorus nanosheet BPNs solid, ultrasonically disperse it into 5-20mL DMF solvent, ultrasonically disperse as water bath ultrasonic or ice bath probe ultrasonic, water bath ultrasonic 5-15min or ice bath probe ultrasonic 10-25s (Switch cycle: 5s / 5s), add in the round bottom two-neck flask with condensing device;

[0042] (2) Add 80-120mg N3-PEG2000 to the flask, and degas the mixture obtained in the above steps by repeatedly freezing in liquid nitrogen, vacuuming, and filling with inert gas such as argon or nitrogen;

[0043] (3) Stir vigorously under the protection of argon or nitrogen after the liquid returns to room temperature, and heat to 120-140°C for 24-48 hours;

[0044] (4) After the reaction, centrifuge the reaction solution returned to room temperature at 10000-15000rpm for 10-20min, wash the solid with ac...

Embodiment 1

[0046] Embodiment 1: Preparation of black phosphorus material BPNs-N3-PEG:

[0047] (1) Take 3mg of black phosphorus nanosheet BPNs solid, ultrasonically disperse it into 5mL of DMF solvent, ultrasonically in a water bath for 5-15min, and add it into a round-bottom double-neck flask with a condensation device;

[0048] (2) Add 80mg of N3-PEG2000 to the flask, and degas the mixture obtained in the above steps by repeatedly freezing in liquid nitrogen, vacuuming, and filling with inert gas such as argon;

[0049] (3) Stir vigorously under the protection of argon after the liquid returns to room temperature, and heat to 120°C for 24 hours;

[0050] (4) After the reaction, the reaction solution returned to room temperature was centrifuged at 10,000 rpm for 10 min, and the solid was washed with acetonitrile several times to remove unreacted N3-PEG2000, washed with water, and freeze-dried;

[0051] (5) The black powder obtained by final drying is the black phosphorus material BPNs-...

Embodiment 2

[0052] Embodiment 2: Preparation of black phosphorus material BPNs-N3-PEG:

[0053](1) Take 6 mg of black phosphorus nanosheet BPNs solid, ultrasonically disperse it into 20 mL of DMF solvent, ultrasonically disperse into an ice-bath probe for 10-25 s, and add it to a round-bottom double-necked flask with a condensation device;

[0054] (2) Add 120mg N3-PEG2000 into the flask, and degas the mixture obtained in the above steps by repeatedly freezing in liquid nitrogen, vacuuming, and filling with inert gas such as nitrogen;

[0055] (3) Stir vigorously under nitrogen protection after the liquid returns to room temperature, and heat to 140°C for 48 hours;

[0056] (4) After the reaction, centrifuge the reaction solution returned to room temperature at 15,000 rpm for 20 min, wash the solid with acetonitrile several times to remove unreacted N3-PEG2000, wash with water, and freeze-dry;

[0057] (5) The black powder obtained by final drying is the black phosphorus material BPNs-N3...

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Abstract

The invention discloses preparation of an oral black phosphorus nano-material and application of the oral black phosphorus nano-material in gastrointestinal diseases, explores the stability of a novel black phosphorus material BPNs-N3-PEG in a mouse with ulcerative colitis, especially in the gastrointestinal tract, adopts a new administration mode, and orally takes BPNs-N3-PEG to treat the ulcerative colitis of the mouse. The possibility of treating mouse ulcerative colitis by oral administration of BPNs-N3-PEG is researched, the application range of BPNs-N3-PEG in the field of biological medicine is widened, and a new thought is provided for treatment of ulcerative colitis.

Description

Technical field: [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to the preparation of an oral black phosphorus nanomaterial and its application in gastrointestinal diseases. Background technique: [0002] Due to its wrinkled honeycomb structure, excellent optical properties, good biodegradability and biocompatibility, black phosphorus materials are widely used in biomedical fields such as tumor photothermal therapy, photodynamic therapy, drug delivery, gene therapy and bioimaging. It has a good application prospect. However, the biodegradability of black phosphorus materials is a double-edged sword. On the one hand, the material can effectively avoid the long-term accumulation problem easily caused by other nano-preparations; on the other hand, the degradation of the material will also greatly affect its biological properties. Functional play. Solving the stability of black phosphorus materials is an urgent task to make them...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/60A61K41/00A61K33/42A61P1/00A61P1/04B82Y5/00B82Y30/00B82Y40/00
CPCA61K41/0052A61K33/42A61K47/60A61P1/04A61P1/00B82Y5/00B82Y30/00B82Y40/00
Inventor 邓文斌刘菁麦扬齐军阳窦浏秦羽嘉
Owner SUN YAT SEN UNIV
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