Preparation of oral black phosphorus nano material and application of oral black phosphorus nano material in gastrointestinal diseases
A technology for gastrointestinal diseases and nanomaterials, which is applied in the field of preparation and its application in gastrointestinal diseases, can solve the problems of non-compliance, difficulty in making injections, difficulty in maintaining uniformity and stability, and achieve stability and dispersion sex enhancing effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0040] The preparation of a kind of oral black phosphorus nanomaterial of the present invention comprises the following steps:
[0041] (1) Take 3-6mg of black phosphorus nanosheet BPNs solid, ultrasonically disperse it into 5-20mL DMF solvent, ultrasonically disperse as water bath ultrasonic or ice bath probe ultrasonic, water bath ultrasonic 5-15min or ice bath probe ultrasonic 10-25s (Switch cycle: 5s / 5s), add in the round bottom two-neck flask with condensing device;
[0042] (2) Add 80-120mg N3-PEG2000 to the flask, and degas the mixture obtained in the above steps by repeatedly freezing in liquid nitrogen, vacuuming, and filling with inert gas such as argon or nitrogen;
[0043] (3) Stir vigorously under the protection of argon or nitrogen after the liquid returns to room temperature, and heat to 120-140°C for 24-48 hours;
[0044] (4) After the reaction, centrifuge the reaction solution returned to room temperature at 10000-15000rpm for 10-20min, wash the solid with ac...
Embodiment 1
[0046] Embodiment 1: Preparation of black phosphorus material BPNs-N3-PEG:
[0047] (1) Take 3mg of black phosphorus nanosheet BPNs solid, ultrasonically disperse it into 5mL of DMF solvent, ultrasonically in a water bath for 5-15min, and add it into a round-bottom double-neck flask with a condensation device;
[0048] (2) Add 80mg of N3-PEG2000 to the flask, and degas the mixture obtained in the above steps by repeatedly freezing in liquid nitrogen, vacuuming, and filling with inert gas such as argon;
[0049] (3) Stir vigorously under the protection of argon after the liquid returns to room temperature, and heat to 120°C for 24 hours;
[0050] (4) After the reaction, the reaction solution returned to room temperature was centrifuged at 10,000 rpm for 10 min, and the solid was washed with acetonitrile several times to remove unreacted N3-PEG2000, washed with water, and freeze-dried;
[0051] (5) The black powder obtained by final drying is the black phosphorus material BPNs-...
Embodiment 2
[0052] Embodiment 2: Preparation of black phosphorus material BPNs-N3-PEG:
[0053](1) Take 6 mg of black phosphorus nanosheet BPNs solid, ultrasonically disperse it into 20 mL of DMF solvent, ultrasonically disperse into an ice-bath probe for 10-25 s, and add it to a round-bottom double-necked flask with a condensation device;
[0054] (2) Add 120mg N3-PEG2000 into the flask, and degas the mixture obtained in the above steps by repeatedly freezing in liquid nitrogen, vacuuming, and filling with inert gas such as nitrogen;
[0055] (3) Stir vigorously under nitrogen protection after the liquid returns to room temperature, and heat to 140°C for 48 hours;
[0056] (4) After the reaction, centrifuge the reaction solution returned to room temperature at 15,000 rpm for 20 min, wash the solid with acetonitrile several times to remove unreacted N3-PEG2000, wash with water, and freeze-dry;
[0057] (5) The black powder obtained by final drying is the black phosphorus material BPNs-N3...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com