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Application of hierarchical pore structure high polymer material as slow-release base material

A polymer material and multi-level pore technology, which is applied to medical preparations containing active ingredients, medical preparations with non-active ingredients, plant raw materials, etc., can solve the problem of short release time of active substances, low utilization rate, and inconvenient operation and other issues to achieve the effect of low volume ratio

Active Publication Date: 2022-05-03
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the small molecular weight of active substances contained in fragrances, essential oils, pharmacological substances, preservatives and disinfectants, etc., they are more sensitive to light and heat, and are easy to volatilize, resulting in a short release time for most active substances, and the stable release function is retained. The deadline cannot be guaranteed; in addition, the existing materials with sustained release function are rare and in a single form
According to market research results, fragrances, essential oils, and pharmacological substance slow-release products mostly use the number of inserted rattans to adjust the release rate of active substances; balm, fragrance tablets, and environmental disinfection substances mostly use the physical pores on the product packaging bottle The size of the active substance is controlled release, which makes the active substance of the commercially available sustained-release products have many defects such as short action time, unstable effect, low utilization rate, and inconvenient operation during use.

Method used

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  • Application of hierarchical pore structure high polymer material as slow-release base material
  • Application of hierarchical pore structure high polymer material as slow-release base material
  • Application of hierarchical pore structure high polymer material as slow-release base material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Add 0.40g of hydrophobic silica particles and 0.40g of dibenzoyl peroxide into the beaker, then add 12.86g of p-chlorostyrene, 2.88g of divinylbenzene, 0.58g of trimethylolpropane triacrylate, 2.88 g polylactic acid (molecular weight: 10,000), stir evenly with a PTFE stirrer to form a uniform reaction mixture; add 80 g of deionized water to the mixture, and stir with a dispersion plate for 10 minutes to form a viscous, stable gel emulsion ; Thermally polymerize the gel emulsion in a water bath, react at room temperature for 8 hours, heat up to 70°C for 12 hours; dry at 80°C to obtain a complete appearance, uniform and delicate density of 0.20g / cm 3 Hierarchical porous polymer materials.

Embodiment 2

[0042] Add 0.80g of hydrophobic silica particles and 0.80g of azobisisobutyronitrile into the beaker, then add 25.73g of α-methylstyrene, 5.76g of diallyl phthalate, and 1.16g of trimethylolpropane in sequence Trimethacrylate, 5.76g polyvinyl chloride paste resin (molecular weight is 62,000), and the dispersing plate is stirred evenly to form a uniform reaction mixture; 60g deionized water is added to this mixture, and the emulsifier is stirred for 15 minutes to form Viscous and stable gel emulsion; thermally polymerize the gel emulsion in a water bath, react at room temperature for 8 hours, heat up to 80°C for 12 hours; dry at 80°C to obtain a complete appearance, uniform and delicate density of 0.40g / cm 3 Hierarchical porous polymer materials.

Embodiment 3

[0044] Add 1.20g of hydrophobic silica particles and 1.20g of dicumyl peroxide into the beaker, then add 35.72g of 4-methylstyrene, 8.64g of ethylene glycol dimethacrylate, and 1.73g of cyanuric acid Triallyl ester, 8.84g polyacrylamide (molecular weight is 15,000), the PTFE stirrer stirs evenly, forms the uniform reaction mixture; Adds 40g deionized water to this mixture, emulsifier stirs 20 minutes, forms viscose Thick and stable gel emulsion; thermally polymerize the gel emulsion in a water bath, react at 40°C for 4 hours, heat up to 90°C for 10 hours; dry at 80°C to obtain a complete appearance, uniform and delicate density of 0.60g / cm 3 Hierarchical porous polymer materials.

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Abstract

The invention discloses application of a hierarchical pore structure high polymer material as a slow-release base material, and belongs to the field of slow-release materials. The density of the hierarchical pore structure high polymer material is 0.20-0.60 g / cm < 3 >, and the hierarchical pore structure high polymer material has a hierarchical pore structure. The rich pore structure of the material can realize gradual adsorption, permeation and desorption of the active substance through the internal and external pressure difference of the slow-release substrate and the affinity between the active substance and the slow-release substrate molecules, the process determines that the active substance is released into the external environment at a stable rate, the slow-release action time is long, and the effect is stable; in addition, due to the hierarchical pore structure of the material, the material has the performance characteristics of heat insulation and heat preservation, and the inactivation and accelerated volatilization of active substances caused by external photo-thermal stimulation, potential safety hazards caused by overlarge internal pressure and the like can be effectively avoided; and on the other hand, the hierarchical pore structure high polymer material has excellent mechanical properties and machining properties, and can be processed into a slow-release base material device with an independent structure.

Description

technical field [0001] The invention belongs to the field of slow-release materials, in particular to the application of a polymer material with a hierarchical porous structure as a slow-release substrate. Background technique [0002] With the continuous improvement of people's living standards, people's requirements for the comfort, health, safety and environmental protection of themselves and their living environment are also getting higher and higher, so the demand for indoor air purification, disinfection, sterilization and odor adjustment is gradually increasing. increase. [0003] At present, there are many odor-sustaining decorations on the market, which are used in indoor homes, cars, hotels, environmental disinfection, and personal accessories. However, due to the small molecular weight of active substances contained in fragrances, essential oils, pharmacological substances, preservatives and disinfectants, etc., they are more sensitive to light and heat, and are ...

Claims

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Application Information

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IPC IPC(8): C08J9/28C08L25/18C08L25/16C08L25/08C08L67/04C08L27/06C08L29/04C08L69/00C08L31/04C08L33/26C08F212/14C08F212/36C08F222/14C08F212/12C08F222/26C08F216/12C08F212/08C08F226/06C08F2/32C11B9/00A61L9/01A61K47/32A61K47/04A61K36/534A61K31/125A61K36/282A61K36/232A61K36/236
CPCC08J9/286C08F212/18C08F212/12C08F212/08C11B9/00A61L9/01A61K47/32A61K47/02A61K36/534A61K31/125A61K36/282A61K36/232A61K36/236C08J2325/18C08J2325/08C08J2325/16C08J2467/04C08J2427/06C08J2433/26C08J2469/00C08J2429/04C08J2431/04A61L2209/21C08F212/36C08F222/103C08F222/26C08F222/102C08F216/125C08F226/06C08F2/32A61K2300/00
Inventor 房喻王佩彭军霞段文倬付宝杰
Owner SHAANXI NORMAL UNIV
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