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Visible light curing biological tissue binding material based on natural polymer as well as preparation method and application of visible light curing biological tissue binding material

A natural polymer and biological tissue technology, applied in the field of visible light-cured biological tissue adhesive materials and its preparation, can solve the problems of inability to adapt to tissue transparency, poor biodegradability, low light transmittance, etc., and achieve good application prospects and value , easy preparation and use, and good biocompatibility

Pending Publication Date: 2022-04-26
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing tissue adhesives such as fibrin glue or cyanoacrylate adhesives have been used in surgery to a certain extent, but their adhesive strength, biocompatibility, or controllability of the adhesive process still remain to be seen. promote
Moreover, in applications that require high optical and tissue compatibility, such as corneal transplantation, the existing adhesives have low light transmittance, poor biodegradability, unsatisfactory adhesive strength, high stiffness and potential cytotoxicity and other issues, unable to meet the organization's needs for transparency

Method used

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  • Visible light curing biological tissue binding material based on natural polymer as well as preparation method and application of visible light curing biological tissue binding material
  • Visible light curing biological tissue binding material based on natural polymer as well as preparation method and application of visible light curing biological tissue binding material
  • Visible light curing biological tissue binding material based on natural polymer as well as preparation method and application of visible light curing biological tissue binding material

Examples

Experimental program
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Effect test

Embodiment 1

[0044] This embodiment provides a natural polymer-based visible light-curable biological tissue adhesive material and its application method, which specifically includes the following steps:

[0045] (1) Dissolve methacryloyl gelatin with a grafting rate of 60% in phenyl(2,4,6-trimethylbenzoyl)lithium phosphate with a mass concentration of 2.5mg / ml in a water bath at 45°C The PBS solution of salt; The PBS solution of the phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt is the phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt Use PBS buffer to configure a solution with a mass concentration of 2.5 mg / ml;

[0046](2) Dissolving oxidized dextran in a PBS solution of phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt with a mass concentration of 2.5 mg / ml at a room temperature of 25° C.; The PBS solution of phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt is to configure phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt with PBS buffer A solution with a ...

Embodiment 2

[0051] The difference between this example and Example 1 is that the mass concentration of the methacrylated gelatin in this example in the mixed solution obtained in step (3) is 100 mg / ml, and the mass ratio of oxidized dextran to It is 2:1.

Embodiment 3

[0053] The difference between this example and Example 1 is that the mass concentration of the methacrylated gelatin in this example in the mixed solution obtained in step (3) is 200 mg / ml, and the mass ratio of oxidized dextran to It is 4:1.

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Abstract

The invention provides a visible light curing biological tissue binding material based on natural macromolecules as well as a preparation method and application of the visible light curing biological tissue binding material. The visible light curing biological tissue adhesive material comprises: a methylacryloylated natural polymer with amino on a main chain, wherein the grafting rate of methacrylic anhydride is 20-80%; oxidizing the polysaccharide; and the photoinitiator is used for initiating photocrosslinking of the methylacryloylated natural polymer. The biological tissue bonding material has good biocompatibility, cells can be adhered and proliferated on the surface or inside of the material, tissue bonding can be achieved under the controllable illumination condition according to needs, and the biological tissue bonding material is of a double-crosslinking network structure after being cured, has good mechanical strength, bonding strength and enzymolysis resistance, has high light transmittance, and can be used as a biological tissue bonding material. The adhesive has controllable curing and bonding processes, is convenient for adjustment and tissue involution before bonding, is simple and convenient to prepare and use, and has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a visible light-curable biological tissue adhesive material based on natural polymers, a preparation method and application thereof. Background technique [0002] Sutures are often used during surgery to close wounds or secure the donor organ to the recipient. However, suture closure is the cause of many postoperative complications, and sutures often need to be removed after recovery from surgery, causing secondary damage to tissue or scarring. Therefore, sutureless wound closure or tissue grafting has distinct advantages. [0003] Bioadhesive materials are a class of biomaterials with tissue-adhesive ability, which can replace surgical sutures to achieve wound closure, shorten operation time, reduce tissue damage, and avoid postoperative complications caused by sutures. When tissue adhesion is achieved, it is achieved through the chemical or physical i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/06
CPCA61L24/043
Inventor 袁进赵轩李赛群
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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