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Developable film for implanting medical device and preparation method of developable film

A technology for implanting medical devices and medicine, applied in pharmaceutical formulations, applications, medical science, etc., can solve the problem that the film cannot be detected by X-ray, and achieve the effect of good application prospects, environmental friendliness, and good biocompatibility

Pending Publication Date: 2022-03-25
MALLOW MEDICAL SHANGHAICO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to provide a method for developing or making a film visible under X-rays in order to overcome the defect that the film cannot be detected by X-rays in the prior art, that is, to provide a method for implanting medical devices Developable films and methods of making the same

Method used

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  • Developable film for implanting medical device and preparation method of developable film
  • Developable film for implanting medical device and preparation method of developable film
  • Developable film for implanting medical device and preparation method of developable film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Make a solution of an appropriate amount of iodophor (containing 0.01g of iodine) and degradable polymer polylactic acid. The mass ratio of iodine in iodophor to polylactic acid is 20:100. (1g) evenly spray the prepared solution on one side of the surface. By drying, the povidone iodine is fixed on the film substrate of the degradable occluder by the degradable polylactic acid to obtain a film with a degradable occluder that can be developed or seen under X-ray irradiation. Since both the degradable polymer polylactic acid and the substrate of the degradable occluder membrane are polymer materials, the degradable polymer polylactic acid can increase the combination of iodophor and the membrane substrate of the degradable occluder Force, so that the development component iodophor is stably placed on the membrane substrate of the degradable occluder. Such as figure 1 As shown, in this solution, one side surface of the film substrate 50 of the degradable occluder is coat...

Embodiment 2

[0058] On the surface of the polydioxanone film substrate (1g) of the degradable occluder, dip-coat iopamidol (containing iodine 0.2g) evenly, by irradiating ultraviolet light for 5 minutes, iopamidol is fixed on On the surface of the membrane of the degradable occluder, a membrane with a degradable occluder that can be visualized or visualized under X-ray irradiation is obtained. Since the ultraviolet rays can increase the binding force between the iopamidol and the membrane of the degradable occluder, the imaging component iopamidol is stably placed on the membrane of the degradable occluder. Such as figure 2 As shown, it is also possible to double-coat the development layer 40 on both sides of the film substrate 50 of the degradable occluder, and the development effect is as follows: Figure 6 shown. In an alternative embodiment, in this solution, one side surface of the film substrate 50 of the degradable occluder is coated with the developing layer 40 on one side. In ...

Embodiment 3

[0060] Such as image 3 As shown, on one side surface of the polycaprolactone film substrate 50 of the degradable occluder, evenly roll-coat an adhesive, such as ultraviolet sensitive glue, to form an adhesive layer 60, and then roll-coat 0.3g iodine on the degradable occluder One side surface of the film substrate (1g) of the occluder has an adhesive, and the iodine is fixed on the film substrate 50 of the degradable occluder by the adhesive, and forms a developing layer 40 to obtain The film of the degradable occluder that can be developed or visible under the film, the developing effect is as follows Figure 7 shown. Since the adhesive can increase the combination of iodine and the film substrate of the degradable occluder, the iodine, the developing component, is stably placed on the film substrate of the degradable occluder.

[0061] In this embodiment, the surface of the film base material of the degradable occluder is coated on one side. surface coating, such as Fi...

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Abstract

The invention discloses a developable film for an implanted medical device and a preparation method of the developable film. The developable film can be developed or visible under X-ray irradiation, the developable film comprises a film base material and a developing component, and the mass ratio of the developing component to the film base material is (1-30): 100; the developable film is prepared by the following steps: (1) carrying out plasma surface treatment on the surface of a film substrate; (2) coating the developing component or a mixture of the developing component and a high polymer material on the surface of the film base material, and fixing the developing component on the surface of the film base material by a drying, active energy ray irradiation or heating sublimation method; or, the developing component and the film base material are combined together by using an adhesive. The developable membrane disclosed by the invention can be degraded by a human body, has good biocompatibility, does not cause inflammation of a patient, and is convenient to observe.

Description

technical field [0001] The present invention relates to a developable film for implanting medical devices and a method for its preparation. Background technique [0002] Traditionally used metal stents for human implantation, such as nickel-titanium alloy stents, can be visualized under X-rays and can determine the position of the implanted product. A certain degree of damage, and therefore a certain defect. [0003] In recent years, with the development of medicine, some temporary materials are often required in modern medical treatment, such as biodegradable polymer materials, which can be used for non-permanent medical devices implanted in the body. Degradable polymer materials are environmentally friendly materials that can be converted into relatively simple intermediate products or small molecules through solvation, simple hydrolysis or enzyme reactions, and other organisms. Therefore, this kind of material can be decomposed in the living body, and the small molecula...

Claims

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Application Information

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IPC IPC(8): A61L31/08A61L31/10A61L31/14A61L31/18A61B90/00A61B34/20
CPCA61L31/08A61L31/10A61L31/18A61L2400/18A61L2420/02A61B17/0057A61B17/12109A61F2/07A61F2/82A61B17/00A61B2017/00575A61F2002/823A61B2017/00831A61B2017/00004A61F2210/00A61F2210/0004A61L2420/06
Inventor 张健张瑾马彩霞张永凯程海波杨晨
Owner MALLOW MEDICAL SHANGHAICO LTD
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