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Tantalum surface calcium-doped sodium tantalate bioactive layer and preparation method thereof

A bioactive, sodium tantalate technology, applied in coating, solid-state diffusion coating, metal material coating process, etc., can solve the problem of no introduction of functional element Ca, poor biological activity of metal tantalum, weak ability to form new bones, etc. problems, to achieve the effect of promoting bone apatite induction, improving biocompatibility, and promoting proliferation

Pending Publication Date: 2022-03-08
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Like most medical metals, tantalum has poor biological activity and weak ability to promote new bone formation, so its clinical application is limited. These problems are urgently needed to be solved when tantalum is used as a hard tissue implant material
There is no report on the introduction of functional element Ca into the surface of tantalum by this method and its use as a medical implant material.

Method used

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  • Tantalum surface calcium-doped sodium tantalate bioactive layer and preparation method thereof
  • Tantalum surface calcium-doped sodium tantalate bioactive layer and preparation method thereof
  • Tantalum surface calcium-doped sodium tantalate bioactive layer and preparation method thereof

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preparation example Construction

[0034] 1. A method for preparing a tantalum surface calcium-doped sodium tantalate bioactive layer, the steps are as follows:

[0035] Step 1: Put the tantalum sheet and NaOH hydrothermal solution into the hydrothermal reactor for hydrothermal treatment, that is, a uniform NaTaO is formed on the surface of the tantalum 3 film layer; wherein the hydrothermal reaction is a chemical reaction as follows:

[0036] 2Ta+10NaOH=Ta 2 o 5 +5Na 2 O+5H 2 ↑

[0037] Ta 2 o 5 +Na 2 O=2NaTaO 3

[0038] Na 2 O+H 2 O=2NaOH

[0039] Step 2: Cover with NaTaO 3 The tantalum sheet of the film layer is placed in CaCl 2 Molten salt treatment is carried out in the powder, that is, doped Ca is formed on the surface of the tantalum 2+ NaTaO 3 film layer.

[0040] The concentration of NaOH solution in step one is 2mol / L.

[0041] In step 1, when the hydrothermal solution is injected into the hydrothermal reaction vessel, the filling degree of the solution is 30%-40%, and then the tanta...

Embodiment 1

[0057] Prepare a NaOH hydrothermal solution with a molar concentration of 2mol / L, inject it into a hydrothermal reaction vessel, and fill the solution with a degree of 30%, soak the tantalum sample in the solution, and treat it hydrothermally at 220°C for 24 hours, namely The sodium tantalate film can be obtained on the surface of the tantalum base, the microstructure of the film is cube-shaped, and the diameter of the cube is about 150 nanometers to 1 micron;

[0058] The treated tantalum sheet covered with sodium tantalate film was buried in anhydrous calcium chloride powder and put into the crucible together. The powder filling degree was 90%. The heating time from room temperature to 450°C was 90 minutes. The holding time is 3 hours, and the calcium-doped sodium tantalate structural coating can be obtained on the tantalum surface after cooling in the furnace. The microstructure of the coating is still cubic, the water contact angle is 66.7°, the roughness Ra value is about...

Embodiment 2

[0060] Prepare a NaOH hydrothermal solution with a molar concentration of 2mol / L, inject it into a hydrothermal reaction vessel, and fill the solution with a degree of 30%, soak the tantalum sample in the solution, and treat it hydrothermally at 220°C for 24 hours, namely The sodium tantalate film can be obtained on the surface of the tantalum base, the microstructure of the film is cube-shaped, and the diameter of the cube is about 150 nanometers to 1 micron;

[0061] The treated tantalum sheet covered with sodium tantalate film was buried in anhydrous calcium chloride powder and put into the crucible together. The powder filling degree was 90%. The heating time from room temperature to 550°C was 90 minutes. The holding time is 3 hours, and the calcium-doped sodium tantalate structural coating can be obtained on the tantalum surface after cooling in the furnace. The microstructure of the coating is still cubic, the water contact angle is 13.9°, the roughness Ra value is about...

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Abstract

The invention discloses a preparation process of a calcium-doped sodium tantalate bioactive film layer on a tantalum surface, which comprises the following steps of: firstly, carrying out hydrothermal treatment on a tantalum substrate by using a NaOH-containing aqueous solution as a hydrothermal solution and adopting an optimal hydrothermal condition, and then carrying out molten salt treatment in calcium-containing powder to obtain a calcium-doped sodium tantalate coating on the tantalum surface. The microstructure of the obtained coating is cubic, the phase is sodium tantalate, calcium is doped in the coating of the cubic structure, the calcium-doped sodium tantalate coating is tightly combined with a base body and good in hydrophilicity, the surface roughness of the obtained film layer is moderate, bone apatite can be rapidly induced to be formed in a similar body fluid environment, osteoblast proliferation can be well promoted, and the bone repairing effect is good. The excellent biological activity is realized.

Description

technical field [0001] The invention belongs to the technical field of surface modification of metal materials, and in particular relates to a calcium-doped sodium tantalate bioactive layer on the surface of tantalum and a preparation method thereof. Background technique [0002] Metal tantalum has excellent ductility, toughness and ease of processing, especially its super corrosion resistance and excellent biocompatibility. Like most medical metals, tantalum has poor bioactivity and weak ability to promote new bone formation, so its clinical application is limited. These problems are urgently needed to be solved when tantalum is used as a hard tissue implant material. Bioactive coatings loaded with functional ions on the surface of tantalum are the main method to improve the biological performance of materials. [0003] Bone regenerative capacity is very important, and calcium ions are considered to be involved in bone metabolism and play a physiological role in angiogenes...

Claims

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Application Information

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IPC IPC(8): C23C22/64C23C22/83C23C10/24
CPCC23C22/64C23C22/83C23C10/24
Inventor 王翠翠张意茹蔡安琦张于浩刘轶凡陈倩宋颖轩殷海荣
Owner SHAANXI UNIV OF SCI & TECH
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