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Phase-transition-adjustable polymer/laponite nano particle compound thermally induced hydrogel as well as preparation method and application of phase-transition-adjustable polymer/laponite nano particle compound thermally induced hydrogel

A nanoparticle and diatomite technology, which is applied in the field of polymer/lithium diatomite nanoparticle composite thermally induced hydrogel and its preparation, can solve problems such as inability to meet, achieve good biocompatibility, and increase the cell's ability to produce energy. sticking effect

Pending Publication Date: 2022-03-08
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although PEG-polyamino acid block polymers are biocompatible and have well-defined thermal gelation properties, unfortunately, PEG-polyamino acid block polymers under many compositional conditions The solution-gel phase transition temperature of block polymer materials is much higher than the human body temperature, which cannot meet the needs of in vivo injection and in situ gel formation

Method used

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  • Phase-transition-adjustable polymer/laponite nano particle compound thermally induced hydrogel as well as preparation method and application of phase-transition-adjustable polymer/laponite nano particle compound thermally induced hydrogel
  • Phase-transition-adjustable polymer/laponite nano particle compound thermally induced hydrogel as well as preparation method and application of phase-transition-adjustable polymer/laponite nano particle compound thermally induced hydrogel
  • Phase-transition-adjustable polymer/laponite nano particle compound thermally induced hydrogel as well as preparation method and application of phase-transition-adjustable polymer/laponite nano particle compound thermally induced hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0037] First, 0.500g (0.25mmol) mPEG 2000 -NH 2 Remove water azeotropically with 50 mL of toluene until the remaining solvent volume is 5 mL, seal the system and cool to room temperature. 0.240g (2.09mmol) L-alanine-N-carboxyl anhydride (L-Ala-NCA) and 0.065g (0.34mmol) L-phenylalanine-N-carboxyl anhydride (L-Phe -NCA) monomer was added to 20 mL of CHCl dried over anhydrous magnesium sulfate 3 / DMF (v / v 3:1) mixed solvent, and magnetically stirred at room temperature for 30min. Under an atmosphere of argon, transfer the solution of mixed monomers to dry mPEG 2000 -NH 2 Then, the temperature of the system was raised to 37° C., and the reaction was carried out under magnetic stirring for 3 days under an atmosphere of argon. The system was then cooled to room temperature, and 20 mL of CHCl was added 3 , after the reaction product was completely dissolved, it was added dropwise into glacial ether for precipitation, and the above operation was repeated three times. Finally, t...

Embodiment 2

[0039] First, 0.500g (0.10mmol) mPEG 5000 -NH 2 Remove water azeotropically with 50 mL of toluene until the remaining solvent volume is 5 mL, seal the system and cool to room temperature. Add 0.012 g (0.10 mmol) of L-alanine-N-carboxy anhydride (L-Ala-NCA) monomer to 20 mL of CHCl dried over anhydrous magnesium sulfate 3 / DMF (v / v 3:1) mixed solvent, and magnetically stirred at room temperature for 30min. Under an atmosphere of argon, transfer the solution of mixed monomers to dry mPEG 5000 -NH 2 Then, the temperature of the system was raised to 37° C., and the reaction was carried out under magnetic stirring for 3 days under an atmosphere of argon. The system was then cooled to room temperature, and 20 mL of CHCl was added 3 , after the reaction product was completely dissolved, it was added dropwise into glacial ether for precipitation, and the above operation was repeated three times. Finally, the product was dried in a vacuum oven at 25°C for 48 hours to obtain the d...

Embodiment 3

[0041] First, 0.500g (0.25mmol) of PEG of diamino 2000 Remove water azeotropically with 50 mL of toluene until the remaining solvent volume is 5 mL, seal the system and cool to room temperature. 0.321g (2.80mmol) L-alanine-N-carboxyl anhydride (L-Ala-NCA) and 0.178g (0.93mmol) L-phenylalanine-N-carboxyl anhydride (L-Phe -NCA) monomer was added to 20 mL of CHCl dried over anhydrous magnesium sulfate 3 / DMF (v / v 3:1) mixed solvent, and magnetically stirred at room temperature for 30min. Under an atmosphere of argon, transfer the solution of mixed monomers to dry NH 2 -PEG 2000 -NH 2 Then, the temperature of the system was raised to 37° C., and the reaction was carried out under magnetic stirring for 3 days under an atmosphere of argon. The system was then cooled to room temperature, and 20 mL of CHCl was added 3 , after the reaction product was completely dissolved, it was added dropwise into glacial ether for precipitation, and the above operation was repeated three times...

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Abstract

The invention belongs to the technical field of biomedical polymer materials, and discloses a polymer / laponite nano particle compound thermotropic hydrogel with adjustable and controllable phase transition as well as a preparation method and application of the polymer / laponite nano particle compound thermotropic hydrogel. The hydrogel is composed of laponite nanoparticles, an amphiphilic block copolymer and a solvent. The gel is in a flowing sol state at low temperature or room temperature, and can spontaneously form thermotropic hydrogel at body temperature along with temperature rise. Wherein the amphiphilic block copolymer is a block copolymer formed by taking polyethylene glycol (PEG) as a hydrophilic block and taking degradable polyamino acid as a hydrophobic block. The laponite and the block copolymer can generate hydrogen bond interaction, and the phase transition temperature of the compound system can be effectively regulated and controlled by regulating and controlling the compounding ratio and concentration of the laponite nanoparticles and the block copolymer. The hydrogel has good biocompatibility and biodegradability, and can meet the application requirements of drug delivery and tissue engineering repair.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, and in particular relates to a thermally induced hydrogel of a polymer / lithium nanoparticle composite whose phase transition can be regulated, as well as its preparation method and application. Background technique [0002] Hydrogels have the characteristics of soft tissue-like mechanical properties, high hydrophilicity, and excellent biocompatibility, which make them have good application prospects in the field of biomedicine. Among them, polymer thermotropic hydrogels undergoing sol-sol transition with increasing temperature have shown great potential in applications such as drug delivery and injectable tissue engineering. [0003] Polymers with thermal gelation properties are usually amphiphilic, biocompatible polyethylene glycol (PEG) is often used for the hydrophilic block, and biodegradable polyamino acids can be selected for the hydrophobic block. The proper ratio of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L77/04C08K7/26A61K9/06A61K47/02A61K47/34A61L27/02A61L27/18A61L27/52
CPCC08J3/075A61K9/06A61K47/02A61K47/34A61L27/52A61L27/025A61L27/18C08J2377/04C08K7/26
Inventor 俞麟庄亚平丁建东
Owner FUDAN UNIV
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