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Traditional Chinese medicine extract for promoting fracture healing as well as preparation method and application of traditional Chinese medicine extract

A fracture healing and extract technology, which is applied in the field of traditional Chinese medicine extract and its preparation to promote fracture healing, can solve the problems of low purity, unstable drug quality, poor effect, etc., and achieve the effect of nourishing the liver and kidney

Pending Publication Date: 2022-03-08
吉林职业技术学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These compound medicines have many flavors, some even dozens of medicinal materials, with complex ingredients, large doses, and low purity; and because it is difficult to unify the harvesting season and location of multi-flavored medicinal materials, it is often necessary to collect all the required medicinal materials. The collected medicinal materials are stored for a long time, and some medicinal materials will lose their medicinal properties during long-term storage, resulting in the disadvantages of unstable drug quality, poor effect, and high cost

Method used

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  • Traditional Chinese medicine extract for promoting fracture healing as well as preparation method and application of traditional Chinese medicine extract
  • Traditional Chinese medicine extract for promoting fracture healing as well as preparation method and application of traditional Chinese medicine extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] S1 according to the method described in the 2015 edition of Chinese Pharmacopoeia to prepare distiller's root and cornus;

[0030] S2 by weight, get 8 parts of wine cornel, 8 parts of Eucommia, 12 parts of psoralen, 8 parts of prickly pear, 10 parts of safflower, 5 parts of salvia, 5 parts of distiller's root and 10 parts of natural copper and grind them. After that, add 528 parts of 95% ethanol to the crushed material, soak for 1h, then reflux for extraction for 1.5h, and filter to obtain the first filter residue and the first filtrate;

[0031] S3 Add 396 parts of 95% ethanol to the first filter residue for reflux extraction for 1.5h, filter to obtain the second filter residue and the second filtrate;

[0032] S4 Add 660 parts of water to the second filter residue for soaking, and distill for 30 minutes at a distillation temperature of 78°C, then decoct the distilled solid-liquid mixture for 40 minutes and then filter to obtain the third filter residue and the third f...

Embodiment 2

[0036] S1 according to the method described in the 2015 edition of Chinese Pharmacopoeia to prepare distiller's root and cornus;

[0037]S2 by weight, get 10 parts of wine cornel, 10 parts of Eucommia, 8 parts of psoralen, 5 parts of prickly pear, 8 parts of safflower, 8 parts of salvia, 8 parts of distiller's root and 8 parts of natural copper and grind them. After that, add 520 parts of 95% ethanol to the crushed material, soak for 1h, then reflux for 2h, and filter to obtain the first filter residue and the first filtrate;

[0038] S3 Add 390 parts of 95% ethanol to the first filter residue for reflux extraction for 2 hours, filter to obtain the second filter residue and the second filtrate;

[0039] S4 Add 650 parts of water to the second filter residue for soaking, and distill for 30 minutes at a distillation temperature of 78°C, then decoct the distilled solid-liquid mixture for 60 minutes and then filter to obtain the third filter residue and the third filtrate ;

[0...

Embodiment 3

[0043] S1 according to the method described in the 2015 edition of Chinese Pharmacopoeia to prepare distiller's root and cornus;

[0044] S2 by weight, get 9 parts of wine cornel, 9 parts of Eucommia, 10 parts of psoralen, 7 parts of cactus, 9 parts of safflower, 6 parts of salvia miltiorrhiza, 6 parts of distiller's root and 9 parts of natural copper and pulverize, pass 40 parts Afterwards, add 520 parts of 95% ethanol to the crushed material, soak for 1h, then reflux for extraction for 1.8h, and filter to obtain the first filter residue and the first filtrate;

[0045] S3 Add 390 parts of 95% ethanol to the first filter residue for reflux extraction for 1.8h, filter to obtain the second filter residue and the second filtrate;

[0046] S4 Add 650 parts of water to the second filter residue for soaking, and distill for 30 minutes at a distillation temperature of 78°C, then decoct the distilled solid-liquid mixture for 50 minutes and then filter to obtain the third filter resid...

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Abstract

The invention provides a traditional Chinese medicine extract for promoting fracture healing and a preparation method and application thereof, and relates to the field of traditional Chinese medicine technology research. The traditional Chinese medicine extract is prepared from the following medicinal raw materials in parts by weight: 8-10 parts of wine-processed fructus corni, 8-10 parts of eucommia ulmoides, 8-12 parts of fructus psoraleae, 5-8 parts of cactus, 8-10 parts of safflower carthamus, 5-8 parts of salvia miltiorrhiza, 5-8 parts of wine-processed rhizoma polygonati and 8-10 parts of native copper, and the medicinal raw materials are subjected to alcohol extraction twice and water extraction twice, concentrated and dried to obtain the traditional Chinese medicine extract. The traditional Chinese medicine composition is applied to all fracture symptoms; the raw materials of the traditional Chinese medicine extract are rich in source, few in needed medicines, convenient to obtain, natural and free of toxic and side effects; the raw materials are sequentially subjected to twice alcohol extraction and twice water extraction, so that water-soluble and alcohol-soluble effective components in the raw materials can be fully extracted, the content of effective medicinal components in the extract is further increased, and the prepared traditional Chinese medicine extract can further promote fracture healing and shorten the fracture healing time; and the curative effect on relieving pain and swelling of a patient after fracture operation is good.

Description

technical field [0001] The invention relates to the technical research field of traditional Chinese medicine, in particular to a traditional Chinese medicine extract for promoting fracture healing, a preparation method and application thereof. Background technique [0002] Fracture refers to the loss of continuity and integrity of bone, and also includes local soft tissue and blood vessel damage. After a fracture, the human body will stimulate a complex cell signaling network to repair the damage and restore function, and finally restore the normal structure and function of the bone. Bone injury includes three continuous processes: inflammation, repair, and reconstruction. After a fracture occurs, a hematoma occurs at the fracture site, and vasoactive substances, inflammatory factors, and growth factors are released from the hematoma; macrophages and other immune cells are recruited to The necrotic tissue is removed from the fracture site, and the growth factors and chemoki...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61P19/08A61K33/26
CPCA61K36/40A61K36/46A61K36/487A61K36/33A61K36/286A61K36/537A61K36/8969A61K33/26A61P19/08A61K2236/333A61K2236/39A61K2236/331A61K2236/51A61K2300/00
Inventor 柳森杨冬吉汲泽李龙吉吴政珉徐萌
Owner 吉林职业技术学院
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