Timolol maleate gel eye drops and preparation method thereof

A technology of timolol acid gel and timolol maleate, which is applied in the directions of pharmaceutical formulation, liquid delivery, emulsion delivery, etc. Long-term effect, good slow-release effect

Active Publication Date: 2022-02-22
WUHAN CONFORM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these eye drops are prepared in the form of a gel, there is still a significant gap in the sustained release rate and duration of the drug

Method used

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  • Timolol maleate gel eye drops and preparation method thereof
  • Timolol maleate gel eye drops and preparation method thereof
  • Timolol maleate gel eye drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The timolol maleate gel eye drops provided in this embodiment comprises 0.4wt% of timolol maleate, 3.6wt% of modified collagen, 3.4wt% of glycerin, and 0.8wt% of medium-chain fatty acid glycerides %, surfactant 0.5wt%, polycarbophil 0.5wt%, and the balance is deionized water. The amount ratio of chitosan and collagen used in the preparation of modified collagen is 1:7.

Embodiment 2

[0033] The Timolol Maleate Gel Eye Drops provided by the present embodiment has the same raw material formulation as in Example 1, except that the amount ratio of chitosan and collagen used in the preparation of modified collagen It is 1:5.5.

Embodiment 3

[0035] The Timolol Maleate Gel Eye Drops provided by the present embodiment has the same raw material formulation as in Example 1, except that the amount ratio of chitosan and collagen used in the preparation of modified collagen It is 1:8.

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PUM

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Abstract

The invention discloses timolol maleate gel eye drops. The timolol maleate gel eye drops are prepared from the following components in percentage by weight: 0.2 to 0.45 percent of timolol maleate, 3.2 to 4.4 percent of modified collagen, 3 to 4 percent of glycerol, 0.5 to 1.0 percent of medium-chain fatty glyceride, 0.4 to 0.6 percent of surfactant, 0.5 percent of polycarbophil and the balance of deionized water, the modified collagen is prepared by the following steps: dissolving chitosan and collagen in an acetic acid solution, shearing and stirring, carrying out ultraviolet irradiation, then adding alkali liquor for neutralization, washing with deionized water, and finally freeze-drying. The timolol maleate gel eye drops provided by the invention are better in slow release effect and longer in lasting period.

Description

technical field [0001] The invention belongs to the field of eye drops for treating glaucoma and ocular hypertension, in particular to timolol maleate gel eye drops. Background technique [0002] Timolol maleate is a powerful β-receptor blocking drug, which has blocking effects on both β1 and β2 receptors, and its effect strength is 8 times that of propranolol. It has no membrane stabilizing effect and no endogenous Sexual sympathomimetic activity, no direct inhibitory effect on the heart, and obvious effect on lowering intraocular pressure. Timolol maleate eye drops are used for the treatment of glaucoma, especially for primary and open-angle glaucoma, and its curative effect is better than traditional ocular hypotensive drugs. It can also be used for postoperative angle-closure glaucoma, aphakic glaucoma, certain secondary glaucoma, ocular hypertension, and glaucoma that is ineffective to drugs and surgery, and can be used in combination with miotics. [0003] In the exi...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/06A61K47/42A61K47/36A61K31/5377A61P27/06
CPCA61K9/08A61K9/0048A61K9/06A61K47/42A61K47/36A61K31/5377A61P27/06
Inventor 周小顺牟东升刘文双吴欢
Owner WUHAN CONFORM PHARMA CO LTD
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