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Application of inhibiting myopia by adjusting eye sclera lipid metabolism

A myopia and inhibitor technology, applied in the field of biomedicine, can solve problems such as unsatisfactory overall effect, large individual drug efficacy differences, toxicity or side effects, etc., to achieve the effect of inhibiting the occurrence and development of myopia, avoiding allergies, and inhibiting the prolongation of the eye axis

Active Publication Date: 2022-02-18
极目峰睿(上海)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that feeding EPA can reduce myopia in mice to a certain extent, but the overall effect is not ideal, especially the slow absorption of gavage or oral administration, the first-pass effect of the drug, and the dose reaching the eye is affected by the blood-ocular barrier. There are large differences in drug efficacy, and large doses have clinical potential toxicity or side effects on other organs, and more optimized treatment options are urgently needed
[0006] Researchers have prepared ophthalmic agents containing omega-3, such as eye drops, eye ointments, implants, ophthalmic gels, etc., but after application (such as eye drops), the subjects often experience tearing and itching , swelling, edema of the upper and lower eyelids, mild conjunctiva hyperemia, mild hyperemia and edema of the bulbar conjunctiva, or flushing around the eyes and other allergic symptoms, which limit the practical application of this ophthalmic preparation

Method used

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  • Application of inhibiting myopia by adjusting eye sclera lipid metabolism
  • Application of inhibiting myopia by adjusting eye sclera lipid metabolism
  • Application of inhibiting myopia by adjusting eye sclera lipid metabolism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Example 1 The close relationship between abnormal scleral metabolism and myopia

[0088] The experimental animals were 3-week-old C57 / BL6 mice. Single-eye form deprivation (Form derivation, FD) was carried out by using the blindfold method. One group of animal experiments was anesthetized and sacrificed 2 days later, and the sclera of both eyes were taken for transcriptome sequencing analysis. After 2 weeks, samples were taken for electron microscope observation.

[0089] Depend on figure 1 It can be seen that after 2 days of form deprivation, compared with the fellow eye, the lipid metabolism signaling pathway in the sclera of myopic eyes has significant changes, and the key enzyme of lipid metabolism in this area, carnitine acyltransferase 2 (Cpt2), is significantly reduced, indicating that the myopic sclera Down-regulation of lipid metabolism pathways.

[0090] Depend on figure 2 It can be seen that after 2 weeks of form deprivation, compared with the fellow eye,...

Embodiment 2

[0091] Example 2 The substance that regulates sclera metabolism can inhibit myopia

[0092] The experimental animals were 3-week-old British tricolor short-haired guinea pigs. Monocular form deprivation (FD) was performed by mask method, and omega-3 polyunsaturated fatty acids were administered to deprived guinea pigs. Animals were randomly divided into 2 groups: form deprivation + solvent control group (FD+vehicle) (the solvent here refers to edible olive oil), form deprivation + drug group (FD+ω-3 (DHA 300mg, EPA60mg)) group . Gastrointestinal administration was carried out at 9 o'clock in the morning every day, and the administration was continued for 2 weeks. Respectively before the experiment, 1 week after administration, and 2 weeks after administration, the diopter was measured by infrared eccentric photorefractor (EIR), the depth of vitreous cavity and the axial length of the eye were measured by A-ultrasound (11MHz). GC-MS) to analyze the lipid metabolism of the sc...

Embodiment 3

[0098] Example 3 The substance that regulates the metabolism of the sclera can inhibit the negative diopter and elongation of the eye axis in myopia

[0099] The experimental animals were 3-week-old British tricolor short-haired guinea pigs. Monocular form deprivation (FD) was carried out by mask method, and the animals were randomly divided into 6 groups to receive the following peribulbar injections of different substances: (1) ethanol solvent group (Vehicle); (2) DHA low-dose group (1.0 μg) ; (3) DHA high-dose group (3.0 μg); (4) EPA low-dose group (1.0 μg); (5) EPA high-dose group (3.0 μg); (6) 0.1% atropine group.

[0100] The measurement methods of diopter, vitreous cavity depth and axial length are the same as in Example 2.

[0101] Depend on Figure 6 It can be seen that form deprivation has successfully induced myopia in guinea pigs, and after two weeks of injection, the myopia progression of guinea pigs treated by the high-dose DHA group was reduced by 35.3% compar...

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Abstract

The invention relates to an application of inhibiting myopia by adjusting eye sclera lipid metabolism. The invention discovers a new mechanism causing myopia, namely close connection between sclera lipid metabolism abnormality and myopia, thereby revealing a brand new myopia prevention and control target; meanwhile, the invention provides eye drops which can effectively prevent and control shortsightedness and can also avoid the problem of eye allergy.

Description

[0001] This application claims the priority of the Chinese invention patent application with application number CN202010976517.X and application date of September 17, 2020. At the same time, this application also claims the priority of the Chinese invention patent application whose application number is CN202110586293.6 and whose application date is May 27, 2021. The entire contents of CN202010976517.X and CN202110586293.6 are incorporated into this application. technical field [0002] The invention relates to an application for inhibiting myopia by regulating eye sclera lipid metabolism, and belongs to the field of biomedicine. Background technique [0003] Myopia is a common type of refractive error. The prevalence of myopia is now becoming an important public health problem in modern society (E. Dolgin, The myopia boom. Nature 519, 276-278 (2015); P. N. Baird et al., Myopia. Nature reviews. Disease primers 6, 99 (2020) ). It is predicted that the proportion of the glo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K9/06A61K9/08A61K31/202A61K31/4409A61K31/455A61K31/46A61K31/517A61K31/7076A61K35/413A61K35/60A61K36/286A61K36/537A61P27/02A61P27/06A61P27/10A23L33/10A23L33/105A23L33/15
CPCA61K45/00A61K31/517A61K31/46A61K31/4409A61K31/455A61K36/537A61K36/286A61K35/60A61K35/413A61K31/7076A61K31/202A61K9/08A61K9/06A61K9/0048A61P27/02A61P27/06A61P27/10A23L33/10A23L33/105A23L33/15A23V2002/00A23V2200/30A23V2250/204A23V2250/21A23V2250/7046A23L33/12A61K45/06A61K9/0051A61K2300/00
Inventor 周翔天潘妙珍赵斐瞿佳
Owner 极目峰睿(上海)生物科技有限公司
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