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Double-layer asymmetric dressing for promoting skin wound repair and preparation method thereof

A wound repair, asymmetric technology, applied in spinning solution preparation, pharmaceutical formula, medical science, etc., can solve the problems of poor affinity of the wound area, insufficient water vapor permeability, etc., to achieve excellent biocompatibility, effective Facilitate adhesion and growth, improve quality and speed

Active Publication Date: 2022-02-11
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these commonly used wound dressings are inexpensive and readily available, they often have poor affinity to the wound area and insufficient moisture vapor permeability

Method used

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  • Double-layer asymmetric dressing for promoting skin wound repair and preparation method thereof
  • Double-layer asymmetric dressing for promoting skin wound repair and preparation method thereof
  • Double-layer asymmetric dressing for promoting skin wound repair and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Preparation of nanofibrous membrane by electrospinning: mix polycaprolactone (PCL) and polylactic acid (PLA) with a mass ratio of 2:1 and dissolve in dichloromethane (DCM) and N-N- In dimethylformamide (DMF) blend solution, at room temperature, magnetically stirred for 24 hours at a speed of 1000r / min, then placed in a magnetic ultrasonic cleaner for 20 minutes to remove air bubbles in the solution, and finally obtained an electrospinning solution. Put the spinning solution in a syringe (20ml), connect the polytetrafluoroethylene hose (1m) and the spinning needle (21G) with an adapter, at an ambient temperature of 25°C, a humidity of 25%, a spinning voltage of 24KV, and a drum speed Under the conditions of 300r / min and spinning extrusion speed of 0.003mm / s, the spinning time lasted 6h to obtain polycaprolactone (PCL) / polylactic acid (PLA) composite electrospun nanofiber membrane.

[0021] Preparation of hydrogel scaffold by 3D printing method: Pour 1.2g polyvinyl alcoho...

Embodiment 2

[0025] The preparation of the electrospun nanofiber membrane, the 3D printed hydrogel scaffold, and the silk fibroin nanofiber solution was the same as in Example 1.

[0026] 3.6g polylactic acid (PLA) was dissolved in 14ml of dichloromethane (DCM) and 6ml of N-N-dimethylformamide (DMF) blend solution, and the upper film was obtained by electrospinning; 1.2g of polyvinyl alcohol ( PVA), 1g sodium alginate (SA), 0.2g chitosan quaternary ammonium salt (HACC) powder were dissolved in 20ml deionized water and mixed evenly, and the hydrogel bottom bracket was prepared by 3D printing method. Dip 0.5ml~1ml of silk fibroin nanofiber solution with a concentration of 0.5wt%~2wt%, and bond the two together. A bilayer asymmetric dressing that promotes wound repair is produced. The average fiber diameter of the electrospun membrane was measured to be 1000nm~1300nm, the water contact angle was 115°~118°, the tensile modulus was 1.8 MPa~2.2 MPa, and the cell survival rates of 1d, 3d, and 5d...

Embodiment 3

[0028] The preparation of the electrospun nanofiber membrane, the 3D printed hydrogel scaffold, and the silk fibroin nanofiber solution was the same as in Example 1.

[0029] Dissolve 2.4g of polycaprolactone (PCL) and 1.2g of polylactic acid (PLA) in 14ml of dichloromethane (DCM) and 6ml of N-N-dimethylformamide (DMF) blend solution, prepared by electrospinning Upper layer membrane: 1g of sodium alginate (SA), 0.2g of chitosan quaternary ammonium salt (HACC) powder was dissolved in 20ml of deionized water and mixed evenly, and the hydrogel bottom layer scaffold was prepared by 3D printing. Dip 0.5ml~1ml of silk fibroin nanofiber solution with a concentration of 0.5wt%~2wt%, and bond the two together. A bilayer asymmetric dressing that promotes wound repair is produced. The average fiber diameter of the electrospun membrane was measured to be 700nm~800nm, the water contact angle was 118°~120°, the tensile modulus was 19.11 MPa~20.41 MPa, and the cell survival rates of 1d, 3d,...

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Abstract

The invention discloses a double-layer asymmetric dressing for promoting skin wound repair and a preparation method thereof, and belongs to the technical field of biomedical materials. According to the invention, a symmetric membrane prepared by adopting electrostatic spinning and 3D biological printing technologies is used as a skin wound dressing, a compact electrostatic spinning nanofiber membrane is prepared from 8-12 wt% of polycaprolactone and 2-6 wt% of polylactic acid blended spinning liquid to simulate an epidermal layer of skin so as to simulate the compactness and waterproof capacity of the epidermal layer, and the top layer of the membrane can be used as a protection barrier so as to prevent permeation of bacteria and microorganisms; a 3D printing hydrogel is prepared from 5 wt% of sodium alginate, 2-8 wt% of polyvinyl alcohol and 1 wt% of chitosan quaternary ammonium salt; and the bottom layer can absorb a large amount of exudate, a proper structure and environment are provided for cell migration and proliferation, and the healing effect of skin wounds is improved.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and in particular relates to a preparation method of a double-layer asymmetric dressing for promoting skin wound repair. Background technique [0002] In recent years, although there are some clinically available skin substitutes, the range of wound types, locations, and application procedures require a wider range of clinical options. Wounds and injuries can be caused by a variety of causes, and depending on the complexity of the wound, wound dressings are designed in different shapes and properties. There are several forms of wound dressings on the market, including occlusive dressings, non-adhesive dressings, absorbent dressings and dressings in sheet, foam, powder and gel form. Although these commonly used wound dressings are inexpensive and readily available, they often have poor affinity to the wound area and insufficient moisture vapor permeability. The purpose of wound dressing is to...

Claims

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Application Information

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IPC IPC(8): A61L15/24A61L15/26A61L15/28A61L15/32A61L15/42A61L15/62B33Y70/00B33Y80/00D01D1/02D01D1/10D04H1/435D04H1/728
CPCA61L15/26A61L15/24A61L15/28A61L15/32A61L15/425A61L15/62D04H1/728D04H1/435D01D1/02D01D1/103B33Y70/00B33Y80/00A61L2400/12C08L67/04C08L29/04C08L5/04C08L5/08C08L89/00
Inventor 连小洁张婷张永刚白金玄甘芳巾黄棣刘阳赵丽琴梁紫微魏延
Owner TAIYUAN UNIV OF TECH
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