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Calculation method for concentration of traditional Chinese medicine components in nanofiltration membrane interface layer

A calculation method and nanofiltration membrane technology, applied in the field of medicine, can solve problems such as the inability to achieve quantitative analysis of the composition of the interface layer.

Active Publication Date: 2022-02-08
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The interface layer produced by the liquid-solid two-phase is a thin layer of fluid formed around or on the surface of the solid relative to the flowing fluid. It is a transition layer formed after the solution contacts the solid, and its physical and chemical properties are different from those of the two-phase solution and solid. , the thickness is between several nanometers and several micrometers, because it is difficult to directly obtain the fluid of the interface layer, so the quantitative analysis of the composition of the interface layer cannot be realized

Method used

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  • Calculation method for concentration of traditional Chinese medicine components in nanofiltration membrane interface layer
  • Calculation method for concentration of traditional Chinese medicine components in nanofiltration membrane interface layer
  • Calculation method for concentration of traditional Chinese medicine components in nanofiltration membrane interface layer

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The concentration of chlorogenic acid in the composite polyamide nanofiltration membrane interface layer in the honeysuckle water extract of embodiment 1

[0020] Weigh the honeysuckle aqueous extract, and detect it by high performance liquid chromatography, and the chromatographic conditions are as follows: Waters e2695 high performance liquid chromatography, full-wavelength ultraviolet detector, Welch ultimate C 18 Chromatographic column, acetonitrile-0.5% phosphoric acid (v / v 30:70), volume flow rate 1.0mL / min, column temperature 30 ℃, detection wavelength 340m, using the external standard point method to calculate the concentration of chlorogenic acid in the water extract of honeysuckle medicinal material is 112.02μg / mL, put 300Da composite polyamide nanofiltration membrane and honeysuckle water extract in the separation system, adjust the transmembrane pressure difference to 0.2, 0.5, 0.8, 1.0, 1.5, 2.0MPa, and collect the corresponding transmembrane pressure Membr...

Embodiment 2

[0027] The concentration of embodiment 2 chlorogenic acid monomer compound in composite polyamide nanofiltration membrane interface layer

[0028] Prepare a chlorogenic acid aqueous solution with a concentration of 112.0 μg / mL and use a 300 Da composite polyamide nanofiltration membrane for separation, adjust the transmembrane pressure difference to 0.2, 0.5, 0.8, 1.0, 1.5, and 2.0 MPa, and collect the corresponding transmembrane pressure differences Under the membrane flux (J), and using the liquid phase detection method in Example 1 to measure and calculate the component rejection rate (R) data.

[0029] According to J and R under a series of transmembrane pressure differences, the membrane separation coefficient k is calculated according to formula (1).

[0030]

[0031] By linear regression on ln[(1-R) ​​J / R] and J, where is the intercept of the linear equation with a slope of 1 / k. The linear equation for fitting ln[(1-R) ​​J / R] and J is: The regression coefficient...

Embodiment 3

[0035] The concentration of matrine and oxymatrine in the interface layer of nanofiltration membrane in embodiment 3 Sophora flavescens

[0036] Weigh 1.0 kg of Sophora flavescens medicinal material, add 10 times of water to extract twice, each time for 1 hour, combine the extracts, and filter through a microporous membrane to obtain Sophora flavescens extract, which is detected by high performance liquid chromatography, and the chromatographic conditions are as follows: Waters e2695 high performance liquid chromatography, full wavelength UV detector, Agilent NH 2 Chromatographic column, acetonitrile-absolute ethanol-3% phosphoric acid (v / v / v 80:10:10), volume flow rate 1.0mL / min, column temperature 25°C, detection wavelength 220nm, external standard one-point method to calculate Sophora flavescens The concentration of matrine in the water extract was 0.46 μg / mL, and the concentration of oxymatrine was 0.53 μg / mL.

[0037] A 500Da polyacrylonitrile nanofiltration membrane was...

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Abstract

The invention discloses a method for calculating the concentration of traditional Chinese medicine components in a nanofiltration membrane interface layer. Aiming at the technical bottlenecks that a liquid-solid interface layer cannot be directly obtained and solute component concentration analysis is difficult to carry out, the invention establishes a calculation method which takes interface mass transfer as a basic theory based on nanofiltration separation. According to the method, a technical means is creatively provided for analyzing the solute distribution behavior of the liquid-solid two-phase interface layer, the affinity of components and a membrane material is intuitively analyzed according to the component concentration distribution condition of the interface layer, and the fundamental reason of membrane pollution is analyzed. The method is beneficial to research and development of new membrane materials, adjustment of distribution concentration differences of different traditional Chinese medicine components on an interface layer, amplification of separation differences and targeted separation.

Description

technical field [0001] The invention relates to a method for calculating the concentration of traditional Chinese medicine components in the interface layer of nanofiltration membranes, in particular to calculating the concentration of components in the interface layer of nanofiltration membranes based on the mode of nanofiltration separation of Chinese medicine components to achieve separation through interface mass transfer, and belongs to the field of medicine. Background technique [0002] The existence of the interface is the root of all interface phenomena. Therefore, in the 19th century, Gibbs discussed the equilibrium conditions of the interface layer to the heterogeneous phase substance, which also led to the analysis methods and theoretical models of the two-phase interface and the interface layer (interface region). widespread attention. At present, in the field of interface chemistry, there are mainly three mainstream understandings of the composition concentrati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/74
CPCG01N30/02G01N30/06G01N30/74G01N2030/065Y02A20/131
Inventor 李存玉支兴蕾彭国平
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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