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Thermosetting resin micro-fluidic chip and preparation method thereof

A microfluidic chip, thermosetting technology, applied in chemical instruments and methods, laboratory utensils, laboratory containers, etc., can solve the problems of easy deformation of thermoplastic polymers when heated, and achieve remarkable elastomer properties, not easy to deform, The effect of avoiding damage to the mold

Pending Publication Date: 2021-12-03
SHANGHAI RES INST OF CHEM IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a thermosetting resin microfluidic chip and its preparation method in order to solve the above problems. Specifically, for the defects of thermoplastic polymers that are easily deformed by heat and PDMS bonding that requires additional processing steps, the present invention proposes a thermosetting resin microfluidic chip. Resin is used as raw material, and by controlling the curing process of resin, a simple thermal bonding process is developed to realize mass production of thermosetting microfluidic chips with high dimensional accuracy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Step 1: Make the mold. Specifically, a positive mold with micron-sized protrusions on the surface is produced by known techniques such as photolithography, photoetching, micromachining, and microelectroforming. The material of the mold can be metal, polymer, or single crystal silicon.

[0042] Step 2: Prepare liquid resin. , After mixing a certain proportion of matrix resin and curing agent (according to the mass ratio of 150:0.5), it is configured to obtain a liquid resin at room temperature, and the resin viscosity is 1000mPa / s. The matrix resin used in this embodiment is bisphenol A epoxy resin, and the curing agent is maleic anhydride.

[0043] Step 3: Fabrication of cover and substrate. Infuse the liquid resin and pour the resin into the mold. The resin is solidified and molded by heating the mold to form a micro-sized flow channel structure and a smooth surface. The heating temperature is 30°C and the heating time is 60 minutes. Stop heating and naturally cool ...

Embodiment 2

[0048] Step 1: Make the mold. Concrete process is with embodiment 1.

[0049] Step 2: Prepare liquid resin. After mixing a certain proportion of matrix resin and curing agent (according to the mass ratio of 220:5), it is prepared to obtain a liquid resin at room temperature, and the resin viscosity is 500mPa / s. The matrix resin used in this embodiment is glycerol type epoxy resin, and the curing agent is triethanolamine.

[0050] Step 3: Fabrication of cover and substrate. Infuse the liquid resin and pour the resin into the mold. The resin is solidified and molded by heating the mold to form a micro-sized flow channel structure and a smooth surface. The heating temperature is 80°C and the heating time is 3 minutes. Stop heating and naturally cool to room temperature to ensure that the resin solidifies and stays in a gel state, and then open the mold. The prepolymer cover sheet and base sheet were obtained, and the Shore hardness of the prepolymer was about 15.

[0051] St...

Embodiment 3

[0055] Step 1: Make the mold. Concrete process is with embodiment 1.

[0056] Step 2: Prepare liquid resin. After mixing a certain proportion of matrix resin and curing agent (according to the mass ratio of 150:0.6), it is prepared to obtain a liquid resin at room temperature, and the resin viscosity is 620mPa / s. The matrix resin used in this embodiment is butylene epoxy resin, and the curing agent is m-phenylenediamine.

[0057] Step 3: Fabrication of cover and substrate. Infuse the liquid resin and pour the resin into the mold. The resin is solidified and molded by heating the mold to form a micro-sized flow channel structure and a smooth surface. The heating temperature is 60°C and the heating time is 20 minutes. Stop heating and naturally cool to room temperature to ensure that the resin solidifies and stays in a gel state, and then open the mold. The cover sheet and the base sheet of the prepolymer were obtained, and the Shore hardness of the prepolymer was about 5. ...

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Abstract

The invention relates to a thermosetting resin micro-fluidic chip and a preparation method thereof, and the preparation method comprises the following steps: preparing a prepolymer: injecting liquid resin into a mold with a microstructure on the inner surface, heating, keeping the constant temperature for preset time, and taking out to obtain a resin prepolymer with a microstructure on the surface as a cover plate; injecting liquid resin into a mold with a smooth inner surface, heating, keeping constant temperature for preset time, and taking out to obtain a resin prepolymer with a smooth surface as a substrate; attaching the surface, with the microstructure, of the cover plate to the substrate, heating and keeping constant temperature for preset time, so that the substrate and the cover plate react and are bonded to obtain a micro-fluidic chip crude product; and carrying out finish machining on the micro-fluidic chip crude product to obtain a micro-fluidic chip finished product. Compared with the prior art, the method has the advantages that the thermosetting engineering resin is used as a raw material, a thermal bonding process with a simple process is developed by controlling a curing process of the resin, and batch production of the thermosetting micro-fluidic chip with high dimensional precision is realized.

Description

technical field [0001] The invention relates to the technical field of manufacturing microfluidic chips, in particular to a thermosetting resin microfluidic chip and a preparation method thereof. Background technique [0002] Microfluidic chips refer to chips with micron-sized channels, which are mainly used in the fields of biochemical analysis, material preparation and organic synthesis. Materials currently used in the fabrication of microfluidic chips include single crystal silicon, glass, alloys, paper and polymers. Among them, polymer microfluidic chips have the advantages of various processing methods, low price, excellent optical properties, and good biocompatibility, so they have become the main direction of academic research and industrialization. [0003] There are two main types of polymer microfluidic chips. The first category is thermoplastic resin, mainly polymethyl methacrylate (PMMA), polycarbonate (PC), polystyrene (PS), etc., and its processing method is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/502707
Inventor 郭松杨维成胡贵宝罗勇方超立段高坤刘建乔新峰乔拟春
Owner SHANGHAI RES INST OF CHEM IND
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