Bi-crosslinked chitosan poly(ester-urethane) modified oxidized starch and preparation method thereof

A technology for oxidizing starch and chitosan, applied in the field of natural polymer materials, can solve the problems of poor biodegradation and absorption performance, cannot be used in the medical field, and difficult to adjust performance, and achieves enhanced water resistance, easy-to-operate components, and good biological properties. Compatibility effect

Active Publication Date: 2021-11-23
山东天铭医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the material is mainly made of physical composites, and the main raw material is polyethanol, which has poor biodegradation and absorption properties.
[0008] It can be seen from the above patent documents that the currently disclosed modified starch technology is mainly used to prepare degraded (or partially degraded) plastics. Although it has mechanical properties, it can only be used in nature to avoid white pollution in nature. It is used in the medical field; and it is mainly the physical compounding of starch, with complex components and difficult adjustment of properties

Method used

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  • Bi-crosslinked chitosan poly(ester-urethane) modified oxidized starch and preparation method thereof
  • Bi-crosslinked chitosan poly(ester-urethane) modified oxidized starch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 10g-NCO-terminated poly(ε-caprolactone) (number average molecular weight is 2000g / mol) and 7.04g chitosan (molecular weight is 2000g / mol, degree of deacetylation 92%) (-NCO and -NH 2 The molar ratio is 1:4) was dissolved in 25mL of N,N-dimethylformamide (DMF) at 5°C, heated to 20°C, and reacted under stirring until the infrared detection-NCO characteristic absorption peak disappeared (about 1.6h), Add the DMF dispersion (12.5g dispersed in 60mL DMF) of oxidized starch (aldehyde group content 1.2mmol / g), react under stirring until the solution becomes viscous (about 15min), stop stirring, and remove the dissolved gas under reduced pressure, Slowly pour it into the mold, let it stand at 40°C to evaporate the solvent to form a film (about 60h), and finally dry the film material under reduced pressure to constant weight to obtain chitosan poly(ester-urethane) modified oxidized starch film M1 .

[0046] The picture of the M1 sample prepared in Example 1 is as figure 1 As s...

Embodiment 2

[0048] 10g-NCO-terminated poly(L-lactide) (number average molecular weight is 2000g / mol) and 7.04g chitosan (molecular weight is 2800g / mol, degree of deacetylation 92%) (-NCO and -NH 2 molar ratio of 1:4) was dissolved in 25mL of N,N-dimethylformamide (DMF) at 5°C, heated to 20°C, and reacted under stirring until the infrared detection-NCO characteristic absorption peak disappeared, and oxidized starch (aldehyde DMF dispersion (12.5g dispersed in 60mL DMF) with a base content of 1.2mmol / g), react under stirring until the solution becomes viscous (about 15min), stop stirring, remove the dissolved gas under reduced pressure, and slowly pour it into the mold in 40° C. to allow the solvent to volatilize to form a film (about 60 h), and finally dry the film material under reduced pressure to constant weight to obtain chitosan poly(ester-urethane) modified oxidized starch film M2.

Embodiment 3

[0050] 7.5g-NCO-terminated poly(ε-caprolactone) (number-average molecular weight is 1500g / mol) and 7.04g chitosan (molecular weight is 2800g / mol, degree of deacetylation 92%) (-NCO and -NH 2 The molar ratio is 1:4) was dissolved in 20mL of N,N-dimethylformamide (DMF) at 5°C, heated to 20°C, and reacted under stirring until the infrared detection-NCO characteristic absorption peak disappeared (about 1.5h), Add the DMF dispersion (13.6g dispersed in 65mL DMF) of oxidized starch (aldehyde group content 1.1mmol / g), react under stirring until the solution becomes viscous (about 18min), stop stirring, and remove the dissolved gas under reduced pressure, Slowly pour it into the mold, let it stand at 40°C to evaporate the solvent to form a film (about 60h), and finally dry the film material under reduced pressure to constant weight to obtain chitosan poly(ester-urethane) modified oxidized starch film M3 .

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Abstract

The invention discloses bi-crosslinked chitosan poly(ester-urethane) modified oxidized starch and a preparation method thereof. According to the invention, a modified starch material is prepared from degradable raw materials, namely -NCO-terminated polyester, chitosan and oxidized starch through a chemical double-crosslinking method, the mechanical property of the material is excellent (wherein breaking strength is greater than 6 MPa, and elongation at break is greater than 150%), the components are few and easy to regulate and control, and meanwhile, the modified starch material has all-degradable and antibacterial properties and can be used for manufacturing various tableware and packaging materials directly making contact with food; and meanwhile, degradation products of the material are non-toxic and absorbable to human bodies and good in biocompatibility, so the degradable food packaging material can be used as a medical material in the medical field.

Description

technical field [0001] The invention belongs to the technical field of natural polymer materials, and in particular relates to a double-crosslinked chitosan poly(ester-urethane) modified oxidized starch and a preparation method. Background technique [0002] Polyurethane (PU) materials are a class of polymer materials with excellent properties, widely used in light industry, textile, medical and other fields, and have become one of the world's six synthetic polymer materials. However, while the extensive use of polyurethane is improving people's lives, it is also attracting people's attention to the depletion of petroleum resources and the negative impact of its waste on the environment. With the improvement of people's awareness of environmental protection, the research and development of environmentally degradable polyurethane materials using renewable natural resources as raw materials is one of the topics that have received considerable attention in recent years. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08J3/24C08L3/10C08L67/04C08L5/08
CPCC08J5/18C08J3/243C08J2303/10C08J2467/04C08J2405/08Y02W90/10
Inventor 张浩候昭升孙晨朱玉正邵帅帅秦建丽
Owner 山东天铭医药科技有限公司
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