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MRI (Magnetic Resonance Imaging) contrast agent based on water-soluble polymer modified magnetic nanoparticles and preparation method of MRI contrast agent

A technology of magnetic nanoparticles and water-soluble polymers, applied in the intersection of materials science and biomedicine, to achieve high relaxation rate ratio, uniform size distribution, and good biocompatibility

Inactive Publication Date: 2021-11-23
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of existing MRI contrast agents, the present invention proposes an MRI contrast agent based on water-soluble polymer-modified magnetic nanoparticles and a preparation method thereof to obtain magnetic Fe with good biocompatibility and stability. 3 o 4 nanoparticles

Method used

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  • MRI (Magnetic Resonance Imaging) contrast agent based on water-soluble polymer modified magnetic nanoparticles and preparation method of MRI contrast agent
  • MRI (Magnetic Resonance Imaging) contrast agent based on water-soluble polymer modified magnetic nanoparticles and preparation method of MRI contrast agent
  • MRI (Magnetic Resonance Imaging) contrast agent based on water-soluble polymer modified magnetic nanoparticles and preparation method of MRI contrast agent

Examples

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Embodiment 1

[0047] The invention provides a method for preparing an MRI contrast agent based on water-soluble polymer-modified magnetic nanoparticles, including the preparation of the water-soluble polymer PTMP-PVP and the preparation of MIONs@PTMP-PVP.

[0048] Wherein, water-soluble polymer PTMP-PVP is prepared through the following steps:

[0049] The monomer VP (6.69g, 60mmol), the chain transfer agent PTMP (0.145g, 0.3mmol, 0.5% monomer), the initiator AIBN (0.098g, 0.6mmol, 1% monomer) and ethanol (25mL) were added to In a four-necked round-bottomed flask, a dispersion of the mixture was obtained. Insert a condenser tube and a thermometer on the device, stir the mixture dispersion in the device with a magnetic stirrer, and pass nitrogen gas for half an hour, then control the temperature at 75°C, and use nitrogen as a protective gas to stir for 5 hours. Then, the reaction mixture was rapidly cooled to room temperature and the product was isolated by precipitation in cold diethyl eth...

Embodiment 2

[0056] This example is basically the same as Example 1, except that the water-soluble polymer PTMP-PVP is prepared through the following steps:

[0057] Add 6.69 g of monomer VP, 0.15 g of chain transfer agent PTMP, 0.098 g of initiator AIBN and 25 mL of ethanol into a four-necked round-bottomed flask to obtain a mixture dispersion. Insert a condenser tube and a thermometer on the device, stir the mixture dispersion in the device with a magnetic stirrer, and pass nitrogen gas for half an hour, then control the temperature at 80°C, and use nitrogen as a protective gas to stir for 4 hours. Then, the reaction mixture was rapidly cooled to room temperature and the product was isolated by precipitation in cold diethyl ether. The precipitated polymer is collected by filtration through a Bush funnel, and the filter material is the polymer PTMP-PVP. After the filtrate was dried and evaporated, 0.5% PTMP-PVP (0.5% is the molar ratio of monomer and chain transfer agent) polymer ligand ...

Embodiment 3

[0059] This embodiment is basically the same as Embodiment 1, the difference is:

[0060] PTMP-PVP@Fe 3 o 4 In the preparation step of nanoparticles, after adding the iron precursor solution to the polymer solution, 100 ml of concentrated ammonia water was added.

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Abstract

The invention discloses an MRI (Magnetic Resonance Imaging) contrast agent based on water-soluble polymer modified magnetic nanoparticles and a preparation method of the MRI contrast agent. The contrast agent comprises Fe3O4 nanoparticles, the surfaces of which are modified with pentaerythritol tetra-3-mercaptopropionate-polyvinyl pyrrolidone (PTMP-PVP). The method comprises the following steps of: obtaining a water-soluble polymer PTMP-PVP by taking pentaerythritol tetra-3-mercaptopropionate (PTMP) as a chain transfer agent and N-vinyl pyrrolidone (VP) as a monomer through free radical polymerization; and then, synthesizing the Fe3O4 nanoparticles coated with the PTMP-PVP by using a coprecipitation method and taking an iron precursor solution as a raw material and the PTMP-PVP as a protective agent. The Fe3O4 nanoparticles prepared by the invention have good stability, biocompatibility and size uniformity, also have a relatively high relaxation rate ratio, and have the potential of being used as a T2 contrast agent.

Description

technical field [0001] The invention relates to the intersection field of material science and biomedicine, in particular to an MRI contrast agent based on water-soluble polymer-modified magnetic nanoparticles and a preparation method thereof. Background technique [0002] Non-invasive and visualized molecular imaging methods can not only reduce the harm to the human body, but also provide effective diagnostic information for various diseases, so they are increasingly favored by people in our daily life. At present, there are many kinds of molecular diagnostic imaging techniques popular in medicine, such as: positron emission tomography (PET), single photon emission computed tomography (SPECT), X-ray computed tomography (CT) and magnetic resonance imaging (MRI). )Wait. Among the above-mentioned imaging techniques, PET, SPECT, CT and X-ray scanning techniques are more harmful and have more hidden dangers to the human body due to ionizing radiation, so magnetic resonance imag...

Claims

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Application Information

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IPC IPC(8): A61K49/12A61K49/18A61K47/58A61K47/69
CPCA61K49/126A61K49/1854A61K47/58A61K47/6931
Inventor 严微宋政伟张刚申
Owner HUBEI UNIV
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