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Hydrogel film and preparation method thereof and ultrasonic coupling patch

A technology of hydrogel film and mixed solution, which is applied in echo/ultrasound imaging agents, drug delivery, emulsion delivery, etc. It can solve the problems of affecting imaging quality and difficult to see superficial tissues, etc., and achieve high imaging quality and easy scale The effect of optimizing production and application and avoiding risks

Active Publication Date: 2021-11-16
THE GBA NAT INST FOR NANOTECHNOLOGY INNOVATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although some existing ultrasonic coupling materials can meet the above conditions, there are still some defects. For example, it is difficult to see superficial tissues during imaging, which affects the imaging quality; Hydration of materials

Method used

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  • Hydrogel film and preparation method thereof and ultrasonic coupling patch
  • Hydrogel film and preparation method thereof and ultrasonic coupling patch
  • Hydrogel film and preparation method thereof and ultrasonic coupling patch

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preparation example Construction

[0070] The present invention also provides the preparation method of above-mentioned hydrogel film, and technical scheme is:

[0071] A method for preparing a hydrogel film, comprising the following steps:

[0072] Mix monomer, gelatin, crosslinking agent, initiator, photoinitiator and water to prepare mixed solution;

[0073] The mixed solution is coated on the substrate and reacted at 50-70° C. to prepare a hydrogel film.

[0074] The raw material cost of the above-mentioned hydrogel membrane is low, the preparation method is simple, and the large-scale production and application are easy.

[0075] In one embodiment, the reaction time is 10 min-30 min.

[0076] Alternatively, the substrate may be a watch glass.

[0077] Understandably, methyl methacrylate and methacrylic acid can undergo free radical polymerization at the above-mentioned temperature under the action of a crosslinking agent and an initiator to generate polymethyl methacrylate. Simultaneously, due to the ad...

Embodiment 1

[0082] This embodiment provides a hydrogel film and a preparation method thereof, the steps are as follows:

[0083]

[0084] 2) Preparation of hydrogel film

[0085] In a 500mL large beaker, mix the above-mentioned methyl methacrylate, methacrylic acid, gelatin, N,N'-methylenebisacrylamide, potassium persulfate, photoinitiator 2959 and deionized water to obtain a mixed solution ;

[0086] Coat the mixed solution on a round watch glass, put it in an oven, and react at 60°C for 20 minutes. During this process, methyl methacrylate and methacrylic acid can be converted into Under the action of amide, potassium persulfate and photoinitiator 2959, a free radical polymerization reaction occurs to generate polymethyl methacrylate. At the same time, due to the addition of gelatin, it can be compounded with polymethyl methacrylate to obtain gelatin / polymethyl methacrylate Methyl acrylate composite hydrogel.

[0087] Soak the gelatin / polymethyl methacrylate composite hydrogel in d...

Embodiment 2

[0089] This embodiment provides a hydrogel film and a preparation method thereof, the steps are as follows:

[0090] 1) Weigh the following raw materials

[0091]

[0092]

[0093] 2) Preparation of hydrogel film

[0094] In a 500mL large beaker, mix the above-mentioned methyl methacrylate, methacrylic acid, gelatin, N,N'-methylenebisacrylamide, potassium persulfate, photoinitiator 2959 and deionized water to obtain a mixed solution ;

[0095] Coat the mixed solution on a round watch glass, put it in an oven, and react at 60°C for 20 minutes. During this process, methyl methacrylate and methacrylic acid can be converted into Under the action of amide, potassium persulfate and photoinitiator 2959, a free radical polymerization reaction occurs to generate polymethyl methacrylate. At the same time, due to the addition of gelatin, it can be compounded with polymethyl methacrylate to obtain gelatin / polymethyl methacrylate Methyl acrylate composite hydrogel.

[0096] Soak ...

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Abstract

The invention relates to the technical field of ultrasonic imaging, in particular to a hydrogel film and a preparation method thereof and an ultrasonic coupling patch. The hydrogel film is prepared from the following raw materials in percentage by mass: 20-60% of a monomer, 15-35% of gelatin, 0.01-1% of a cross-linking agent, 0.01-1.5%of an initiator, 0.01-1.5%of a photoinitiator, and the balance of water, wherein the monomer is methacrylic acid and / or methyl methacrylate. The hydrogel film is in a solid film shape and can be used as an ultrasonic coupling material, so that superficial tissue can be seen in an ultrasonic image, and the imaging quality is high.

Description

technical field [0001] The invention relates to the technical field of ultrasonic imaging, in particular to a hydrogel film, a preparation method thereof and an ultrasonic coupling patch. Background technique [0002] Ultrasound imaging technology has many advantages such as no damage, no ionizing radiation, relatively simple operation, low cost, no pollution, real-time imaging, etc., and is widely used in the inspection and diagnosis of ophthalmology, digestive system, urinary system, obstetrics and gynecology and cardiovascular system Among them, it is one of the most widely used medical imaging diagnostic methods in clinical practice. [0003] The ultrasonic probe is the most critical acoustic component in the medical ultrasonic imaging system. When it is working, in order to obtain high-quality ultrasonic images, it is necessary to fill the ultrasonic coupling material between the probe and the contact point of the human body to reduce the penetration of air into the ult...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/12C08L33/02C08L89/00C08J5/18C08J3/075C08F220/14C08F220/06A61K49/22
CPCC08J5/18C08J3/075C08F220/14C08F220/06A61K49/226C08J2333/12C08J2489/00C08J2333/02Y02A50/30
Inventor 刘颖孙迪陈春英赵宇亮
Owner THE GBA NAT INST FOR NANOTECHNOLOGY INNOVATION
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