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Intravascular stent and preparation method thereof

A vascular stent and vascular endothelial technology, applied in the field of medical devices, can solve the problems of artificial blood vessel thrombosis, long operation time, and strict medical conditions

Inactive Publication Date: 2021-11-16
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main method of the artificial blood vessel transplantation operation is the vascular anastomosis technique, that is, the purpose of repairing is achieved by suturing the two ends of the artificial blood vessel and the broken blood vessel. Medical requirements can be very stringent
In addition, systemic heparinization is required before suturing with ordinary artificial blood vessels, otherwise thrombus may easily occur in the artificial blood vessels and cause blockage. However, systemic heparinization will further increase the blood loss of the wounded and lead to hemorrhagic shock. Systemic heparinization is less desirable

Method used

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  • Intravascular stent and preparation method thereof
  • Intravascular stent and preparation method thereof
  • Intravascular stent and preparation method thereof

Examples

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preparation example Construction

[0033] The invention provides a method for preparing a stent, comprising the following steps:

[0034] A nonionic surfactant solution and a polymer solution are provided; the polymer solution includes a thermally induced shape memory polymer and a vascular endothelial growth factor;

[0035] performing a first electrospinning of the nonionic surfactant solution to obtain a tubular water-soluble template fiber membrane;

[0036] Using the tubular water-soluble template fiber membrane as a receiving substrate, performing a second electrospinning of the polymer solution to obtain a first stent precursor;

[0037] After removing the nonionic surfactant in the first stent precursor, cross-link mTG enzyme to obtain the second stent precursor;

[0038] Loading heparin on the inner wall of the second vascular stent precursor to obtain the vascular stent.

[0039] In the present invention, unless otherwise specified, all preparation materials are commercially available products well ...

Embodiment 1

[0113] Pluronic F127 (M w =12,600Da) and deionized water were mixed, and magnetically stirred for 2 hours in an environment of 4°C to obtain a Pluronic F127 hydrogel solution with a concentration of 35wt%;

[0114] Put 12g of polyε-caprolactone diol into a three-necked flask filled with nitrogen after drying by rotary evaporation, and put it into an oil bath at 60°C for 1 hour under the condition of stirring to completely melt the polyε-caprolactone diol , lowered to room temperature, added 1.5mL hexamethylene diisocyanate, heated to 60°C, stirred for 3h, added 4mL isophorone diisocyanate and 12mL dimethyl carbonate, stirred for 30min, added 0.05mL dibutyltin dilaurate , a prepolymerization reaction occurs for 1 hour to obtain a prepolymer;

[0115] 1.6 mL of 1,4-butanediol was added to the prepolymer, and a chain extension reaction occurred for 4 hours to obtain polyurethane;

[0116] Mix the polyurethane and 12mL dimethyl carbonate to obtain a polyurethane solution, pour i...

Embodiment 2

[0125] Mix 1.0g of PVP and 9.0g of ethanol and stir for 3h to obtain the ethanol solution of PVP;

[0126] Put 12g of polyε-caprolactone diol into a three-necked flask filled with nitrogen after drying by rotary evaporation, and put it into an oil bath at 60°C for 1 hour under the condition of stirring to completely melt the polyε-caprolactone diol , lowered to room temperature, added 1.5mL hexamethylene diisocyanate, heated to 60°C, stirred for 3h, added 4mL isophorone diisocyanate and 12mL dimethyl carbonate, stirred for 30min, added 0.05mL dibutyltin dilaurate , a prepolymerization reaction occurs for 1 hour to obtain a prepolymer;

[0127] 1.6 mL of 1,4-butanediol was added to the prepolymer, and a chain extension reaction occurred for 4 hours to obtain polyurethane;

[0128] Mix the polyurethane and 12mL dimethyl carbonate to obtain a polyurethane solution, pour it into a polytetrafluoroethylene mold, and put it into a vacuum oven for curing. The curing temperature is 90...

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Abstract

The invention relates to the technical field of medical instruments, in particular to an intravascular stent and a preparation method thereof. The thermal induction type shape memory high-molecular polymer is adopted as an intravascular stent material, and deformation can be generated under the influence of the body temperature of a human body, so that the two ends of a broken blood vessel are supported, and blood flow is unblocked; meanwhile, vascular endothelial growth factors are added into the vascular stent material, so that endothelial cells in blood can be collected, the endothelialization rate is increased, cells on the most superficial layer of the endovascular intima of a human body grow towards the lumen surface of an artificial blood vessel, and a layer of membranous tissue of the endothelial cells is formed; thus, the number of platelets can be reduced by loading heparin on the inner wall of the intravascular stent, so that the thrombus symptom is relieved.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a vascular stent and a preparation method thereof. Background technique [0002] The main methods of vascular injury treatment at home and abroad are hemostasis, ligation and vascular anastomosis. For the injury of some important blood vessels, such as carotid artery, axillary artery, brachial artery, femoral artery, and popliteal artery, if only hemostasis and ligation are performed, and the blood supply is not restored in time, it will lead to serious consequences, such as amputation or even death. At present, artificial blood vessel transplantation is the main means of restoring its blood supply function in time. The main method of the artificial blood vessel transplantation operation is the vascular anastomosis technique, that is, the purpose of repairing is achieved by suturing the two ends of the artificial blood vessel and the broken blood vessel. Medical require...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/04A61L31/14A61L31/16A61F2/82
CPCA61L31/06A61L31/048A61L31/047A61L31/042A61L31/14A61L31/16A61F2/82A61F2210/0019A61L2400/16A61L2300/414A61L2300/42A61L2300/236C08L89/00C08L5/10C08L71/02C08L39/06C08L67/04C08L75/04
Inventor 胡庆夕黄振威张海光
Owner SHANGHAI UNIV
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