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A memory alloy esophageal stent modified by nano-copper sulfide coating and its preparation method

A technology of memory alloy and copper sulfide, applied in coatings, stents, pharmaceutical formulations, etc., can solve the problems of tumor restenosis and inability to treat tumors, and achieve the effect of simple treatment process, good photothermal conversion effect and simple method

Active Publication Date: 2022-05-24
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the self-expanding stent currently used clinically can only rely on physical expansion to treat esophageal stenosis, and cannot treat the tumor itself, nor can it fundamentally solve the problem of restenosis caused by tumor regrowth

Method used

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  • A memory alloy esophageal stent modified by nano-copper sulfide coating and its preparation method
  • A memory alloy esophageal stent modified by nano-copper sulfide coating and its preparation method
  • A memory alloy esophageal stent modified by nano-copper sulfide coating and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A preparation method for growing copper sulfide nanoparticles in situ on a nickel-titanium alloy wire, comprising the following steps:

[0038] 1) Preparation of dopamine-coated nickel-titanium stent: firstly, the surface of the nickel-titanium alloy stent was cleaned, and then the stent was immersed in 8 mM Tris-HCl buffer solution (pH 8.5). Add dopamine to the solution to make the final solubility 2 mg / mL, and stir rapidly in the dark for 8 hours; take out the stent, and wash the polydopamine-coated stent three times with deionized water.

[0039] 2) Submerge the dopamine-coated stent in a beaker containing 400mL of 0.5mg / mL PVA solution, stir at 1000rpm for 20min, then add 150mg of CuSO 4 ·5H 2 O and 75 mg Na 2 S 2 o 3 ·5H 2 O was added to the PVA solution to give a green colloidal solution.

[0040] 3) Next, the mixture was heated to 80°C and kept for 2h. After the reaction, let it cool down to room temperature naturally, take out the product and rinse it wit...

Embodiment 2

[0042] A preparation method for growing copper sulfide nanoparticles in situ on a nickel-titanium alloy wire, comprising the following steps:

[0043] 1) Preparation of dopamine-coated nickel-titanium stents: firstly, after cleaning the surface of the nickel-titanium alloy stents, immerse the stents in 10mM Tris-HCl buffer (pH 8.5), and add dopamine to the solution to make the final solubility 5mg / mL, and stirred rapidly for 12 h in the dark; take out the stent, and wash the polydopamine-coated stent three times with deionized water.

[0044] 2) Submerge the dopamine-coated stent in a beaker containing 400mL of 3mg / mL PVA solution, stir at 1000rpm for 30min, then add 300mg of CuSO 4 ·5H 2 O and 150 mg Na 2 S 2 o 3 ·5H 2 O was added to the PVA solution to give a green colloidal solution.

[0045]3) Next, the mixture was heated to 80°C and kept for 2h. After the reaction was completed, it was allowed to cool down to room temperature naturally. The product was taken out ...

Embodiment 3

[0047] A preparation method for growing copper sulfide nanoparticles in situ on a nickel-titanium alloy wire, comprising the following steps:

[0048] 1) Preparation of dopamine-coated nickel-titanium stent: firstly, the surface of the nickel-titanium alloy stent was cleaned, and then the stent was immersed in 10 mM Tris-HCl buffer solution (pH 8.5). Add dopamine to the solution to make the final solubility 5mg / mL. Stir rapidly in the dark for 8 hours; take out the stent, and wash the polydopamine-coated stent three times with deionized water.

[0049] 2) Submerge the dopamine-coated stent in a beaker containing 400mL of 5mg / mL PVA solution, stir at 1000rpm for 20min, then add 150mg of CuSO 4 ·5H 2 O and 75 mg Na 2 S 2 o 3 ·5H 2 O was added to the PVA solution to give a green colloidal solution.

[0050] 3) Next, the mixture was heated to 80°C and kept for 2h. After the reaction was completed, it was allowed to cool down to room temperature naturally. The product was ...

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Abstract

The invention belongs to the technical field of medical devices, and relates to a memory alloy esophageal stent with a uniform nano-copper sulfide film with high-efficiency photothermal physiotherapy function and a preparation method thereof. The stent reduces dopamine under alkaline conditions to obtain a polydopamine-coated memory alloy The scaffold is prepared by the method of in-situ growth of copper sulfide by polydopamine efficiently adsorbing copper ions under heating conditions. The method of the present invention adopts a unique method of in-situ growing nano-CuS particles on the surface of the support. The nano-CuS material is safe and non-toxic, and the growth process is simple and fast; the light-to-heat conversion is efficient and can be used repeatedly; the present invention can be used in various shapes and Other types of nickel-titanium alloy stents, such as biliary stents, intestinal stents, urinary tract stents, and tracheal stents.

Description

technical field [0001] The invention belongs to the field of biomedical devices, and in particular relates to a memory alloy esophageal stent modified with a nano-copper sulfide coating and a preparation method thereof, which can be used for photothermal treatment of esophageal cancer under near-infrared laser irradiation. Background technique [0002] Esophageal cancer is the sixth leading cause of cancer death in the world. As a country with a high incidence of esophageal cancer, my country's incidence rate of esophageal cancer is about 20-30 times higher than that of European and American countries, ranking fourth among cancer-related deaths in China. Surgery, radiotherapy and chemotherapy are the three major clinical methods for the treatment of esophageal cancer. However, 60% of the patients with esophageal cancer are already in the middle and advanced stages of cancer when they see a doctor, and they basically lose the opportunity for surgical treatment. However, due t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/08A61L31/14A61L31/02A61F2/82A61B18/04
CPCA61L31/088A61L31/14A61L31/022A61F2/82A61B18/04A61L2400/16A61L2400/12A61L2300/102A61L2300/416A61L2300/606A61F2210/00A61F2240/001
Inventor 张璇吴颖苏礼超宋继彬
Owner FUZHOU UNIV
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