A kind of cobalt-manganese-iron hydrotalcite-based nanocomposite material and its preparation method and application

A nano-composite material and talc-based technology, which is applied in the field of cobalt-manganese-iron-hydrotalcite-based nanocomposite materials and its preparation, can solve problems such as insurmountable limitations and unsatisfactory treatment effects, and achieve improved photodynamic effects and easy operation , the effect of improving performance

Active Publication Date: 2022-05-06
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, through research and comparison, it is found that the usual single treatment method cannot be overcome due to its own limitations, and the treatment effect is not ideal.

Method used

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  • A kind of cobalt-manganese-iron hydrotalcite-based nanocomposite material and its preparation method and application
  • A kind of cobalt-manganese-iron hydrotalcite-based nanocomposite material and its preparation method and application
  • A kind of cobalt-manganese-iron hydrotalcite-based nanocomposite material and its preparation method and application

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preparation example Construction

[0030] The invention provides a method for preparing a cobalt-manganese-ferrohydrotalcite-based nanocomposite material, comprising the following steps:

[0031] mixing a mixed metal salt solution, an alkaline solution and a sodium nitrate solution containing formamide, and performing a co-precipitation reaction to obtain hydrotalcite nanosheets; the metal salts in the mixed metal salt solution include cobalt salts, manganese salts and iron salts;

[0032] The hydrotalcite nanosheets, the zinc phthalocyanine ethanol solution and the glucose oxidase aqueous solution are mixed and loaded to obtain a cobalt-manganese-iron hydrotalcite-based nanocomposite material.

[0033] In the present invention, unless otherwise specified, the required preparation materials are commercially available products well known to those skilled in the art.

[0034] The invention mixes the mixed metal salt solution, the alkaline solution and the sodium nitrate solution containing formamide to carry out ...

Embodiment 1

[0057] Synthesis of cobalt manganese iron (molar ratio of metal elements is 1:0.75:0.25) hydrotalcite (CoMnFe-LDH):

[0058] 0.20mmolCo(NO 3 ) 2 ·6H 2 O, 0.15mmolFe(NO 3 ) 3 9H 2 O and 0.05mmol Mn(NO 3 ) 2 ·6H 2 O was dissolved in 10mL deionized water to obtain a cobalt-manganese-iron salt solution;

[0059] Dissolve 0.0025mol NaOH in 10mL deionized water to obtain sodium hydroxide solution;

[0060] 0.1mmol NaNO 3 and 50mmol formamide were dissolved in 10mL deionized water to obtain a sodium nitrate solution containing formamide;

[0061] At a dropping rate of 2 μL / s, drop cobalt-manganese-iron-iron salt solution and sodium hydroxide solution into the sodium nitrate solution containing formamide at the same time and at a constant speed, control the pH value of the resulting mixed material to 9, and stir in an oil bath at 80°C Under the conditions until the dripping is completed, the co-precipitation reaction was carried out for 15 minutes; the obtained system was n...

Embodiment 2

[0064] Prepare the cobalt manganese iron hydrotalcite colloid solution that concentration is 1mg / mL according to the method for embodiment 1;

[0065]2.5mgZnPc is dissolved in the ethanol solution of volume fraction 60% to obtain 2.5mL solution, 5mgGOD is dissolved in deionized water to obtain 1mL solution, add the above-mentioned cobalt manganese iron hydrotalcite colloid solution (Co 1 mn 0.75 Fe 0.25 -LDH), stirred at a stirring speed of 400r / min for 3h under dark conditions, and centrifuged to remove the supernatant to obtain a cobalt-manganese-iron hydrotalcite-based composite material, which was recorded as GOD&ZnPc-LDH (1:0.5:1).

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Abstract

The invention provides a cobalt-manganese-iron hydrotalcite-based nanocomposite material and its preparation method and application, belonging to the technical field of preparation of medical tumor treatment materials. The present invention loads the photosensitizer zinc phthalocyanine and the antitumor drug glucose oxidase on the CoMnFe-LDH nanosheet, and the hydrotalcite can specifically respond under tumor microenvironmental conditions, improving the effects of chemodynamic therapy and photodynamic therapy; zinc phthalocyanine can make It is specifically released in the tumor microenvironment, which can improve the photodynamic effect of photosensitizers, and can effectively generate singlet oxygen under external light conditions, so as to achieve targeted and specific therapeutic effects, and improve the photodynamic effect of traditional zinc phthalocyanine. Therapeutic performance: Glucose oxidase can consume the internal supply substance glucose of tumor cells and produce hydrogen peroxide and gluconic acid to achieve a self-enhanced chemokinetic therapeutic effect, thereby realizing the PDT / CDT synergistic therapy in response to the tumor microenvironment.

Description

technical field [0001] The invention relates to the technical field of preparation of medical tumor treatment materials, in particular to a cobalt-manganese-iron hydrotalcite-based nanocomposite material and a preparation method and application thereof. Background technique [0002] Malignant tumors are caused by many factors, including genetic factors, external environmental pollution and long-term bad living habits. Currently, clinically, the main treatment methods for malignant tumors include chemotherapy, radiotherapy, surgical resection, and immunotherapy. Among them, chemotherapy is to inhibit the DNA and RNA synthesis and transcription of tumor cells through external chemotherapy drugs, leading to cell apoptosis. In the current treatment of malignant tumors, chemotherapy is the most effective way, but it will reach the organs of the body along with the blood, and it will also damage normal cells while exerting anti-cancer effects, which has relatively large toxic and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/02A61K41/00A61K38/44A61P35/00B82Y5/00B82Y40/00
CPCA61K47/02A61K41/0071A61K38/443C12Y101/03004A61P35/00B82Y5/00B82Y40/00A61K2300/00
Inventor 梁瑞政王慧胡婷婷吴静静
Owner BEIJING UNIV OF CHEM TECH
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