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Polydopamine-coated zirconium-based metal organic material as well as preparation method and application thereof

A technology of polydopamine and organic materials, applied in botany equipment and methods, applications, chemicals for biological control, etc., can solve the problems of inability to generate enough heat, reduce the utilization rate of photosensitizers, effectively and quickly kill bacteria, etc. problem, achieve the effect of low implementation difficulty, simple and easy preparation method, and high stability

Inactive Publication Date: 2021-03-05
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the current photosensitizers are all small molecules, especially porphyrin and its derivatives, which have strong hydrophobic properties, and will obviously agglomerate under aqueous conditions, resulting in fluorescence quenching and reducing the utilization rate of photosensitizers.
[0004] The photosensitizers currently used cannot generate enough heat under light conditions, and relying solely on the free radicals generated cannot achieve effective and rapid killing of bacteria, and the antibacterial ability needs to be further improved

Method used

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  • Polydopamine-coated zirconium-based metal organic material as well as preparation method and application thereof
  • Polydopamine-coated zirconium-based metal organic material as well as preparation method and application thereof
  • Polydopamine-coated zirconium-based metal organic material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A preparation method for polydopamine-wrapped zirconium-based metal-organic materials, comprising the following steps:

[0057] Step 1, to prepare a metal organic framework structure, add 40mg of tetrakis (4-carboxyphenyl) porphine, 120mg of zirconium oxychloride monohydrate, and 1200mg of benzoic acid into 8mL of dimethylformamide, ultrasonic (300kHZ, 20min) Make it completely dissolved, add the solution into a high-pressure reactor, and prepare a metal-organic framework structure using a hydrothermal method. The reaction temperature of the hydrothermal method is 120° C., and the reaction time is 24 hours, and then gradually slowly return to room temperature;

[0058] In step 2, the metal-organic framework obtained in step 1 was washed three times with dimethylformamide, and then dispersed in a tris-HCl (tris(hydroxymethyl)aminomethane-hydrochloric acid) buffer solution in which dopamine was dissolved. The mass ratio of the buffer solution to the metal-organic framewor...

Embodiment 2

[0060] A preparation method for polydopamine-wrapped zirconium-based metal-organic materials, comprising the following steps:

[0061] Step 1, to prepare a metal organic framework structure, add 40mg of tetrakis (4-carboxyphenyl) porphine, 120mg of zirconium oxychloride monohydrate, and 1200mg of benzoic acid into 8mL of dimethylformamide, ultrasonic (300kHZ, 20min) Make it completely dissolved, add the solution into a high-pressure reactor, and prepare a metal-organic framework structure using a hydrothermal method. The reaction temperature of the hydrothermal method is 120° C., and the reaction time is 24 hours, and then gradually slowly return to room temperature;

[0062] In step 2, the metal-organic framework obtained in step 1 was washed three times with dimethylformamide, and then dispersed in a tris-HCl (tris(hydroxymethyl)aminomethane-hydrochloric acid) buffer solution in which dopamine was dissolved. The mass ratio of the buffer solution to the metal-organic framewor...

Embodiment 3

[0064] A preparation method for polydopamine-wrapped zirconium-based metal-organic materials, comprising the following steps:

[0065] Step 1, to prepare a metal organic framework structure, add 40mg of tetrakis (4-carboxyphenyl) porphine, 120mg of zirconium oxychloride monohydrate, and 1200mg of benzoic acid into 8mL of dimethylformamide, ultrasonic (300kHZ, 20min) Make it completely dissolved, add the solution into a high-pressure reactor, and prepare a metal-organic framework structure using a hydrothermal method. The reaction temperature of the hydrothermal method is 120° C., and the reaction time is 24 hours, and then gradually slowly return to room temperature;

[0066] In step 2, the metal-organic framework obtained in step 1 was washed three times with dimethylformamide, and then dispersed in a tris-HCl (tris(hydroxymethyl)aminomethane-hydrochloric acid) buffer solution in which dopamine was dissolved. The mass ratio of the buffer solution to the metal-organic framewor...

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Abstract

The invention discloses a preparation method of a polydopamine-coated zirconium-based metal organic material. The method comprises the following steps of: 1. Uniformly dispersing porphyrin derivatives, zircon salt and benzoic acid micromolecules into an organic solvent, and preparing a metal organic framework structure by using a hydrothermal method; and 2, cleaning the metal organic framework structure obtained in the step 1, dispersing the metal organic framework structure in a tris-HCl buffer solution dissolved with dopamine, and reacting for 6-24 hours at the reaction temperature of 15-30DEG C to obtain the polydopamine-coated zirconium-based metal organic material. The polydopamine can effectively improve the dispersity of particles in water, thereby effectively increasing the utilization rate of the material. The material can also absorb visible light to be heated and generate a large amount of reactive oxygen species (ROS) to achieve photo-thermal and photodynamic synergistic sterilization, and can effectively kill bacteria under the condition of low free radical demand.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a polydopamine-wrapped zirconium-based metal organic material, a preparation method and an application thereof. Background technique [0002] In daily life, wounds appear on the skin is a very common thing. In the process of wound healing, if bacterial infection occurs, it will affect the speed of wound healing, and even cause the wound to fail to heal. In order to avoid bacterial infection of the wound, the use of antibiotics is currently the most common treatment option. The extensive use of antibiotics has led to the emergence of drug-resistant bacteria. These drug-resistant bacteria can ignore the attack of most antibiotics, leading to the status quo of no drugs available, threatening human life. Therefore, it is extremely urgent to develop new, fast, effective, non-antibiotic antibacterial agents. [0003] Photosensitizers can generate heat and f...

Claims

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Application Information

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IPC IPC(8): C08G83/00C08G73/06A01N59/00A01P1/00
CPCC08G83/008C08G73/0672A01N59/00
Inventor 吴水林韩冬琳刘想梅
Owner TIANJIN UNIV
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