A nanocomposite material used in photodynamic therapy and its preparation method

Abstract

The invention provides a nano-composite material applied to photodynamics therapy and a preparation method thereof. The method comprises the following steps: (1) ensuring that rare-earth up-conversion materials are high-quality nano-particles which can be used for effectively transmitting near-infrared light to photosensitive medicine molecules; (2) controlling the thickness of mesoporous SiO2 according to the conditions such as the concentration of UCNPs, the quantity of hexadecyl trimethyl ammonium bromide and tetraethoxysilane and the reaction temperature and time; (3) modifying UCNPs @SiO2 by using Au25 to prepare the nano-particles to ensure that the photodynamic performance of the nano-particles can be obviously improved. A nano-carrier which is uniform, high in monodisperse property and controlled in sizes (50-100 nm) and of which the mesoporous SiO2 covers the up-conversion nano-particle core-shell structure is provided; moreover, through a proper adsorption method, a photosensitizer medicine molecule Au25 (Capt)18-(Au25) is bonded to a mesoporous SiO2 framework to build a multifunctional composite material, and the current problem of photodynamics therapy (PDT) can be solved by using the material.

Description

Technical field [0001] The invention relates to a nano composite material, and the invention also relates to a preparation method of the nano composite material. Specifically, it relates to a nano composite material applied to photodynamic therapy and a preparation method thereof. Background technique [0002] Photodynamic therapy (PDT) is a new technology for the diagnosis and treatment of diseases based on the interaction of light, photosensitizer and oxygen. The basic principle is that the photosensitizer molecules are excited to Excited state and transfer its energy to the surrounding oxygen molecules, thereby generating singlet oxygen ( 1 O 2 ) Or free radicals and other reactive oxygen species (ROS), which cause tissue and organ damage and damage the target tissue to achieve the purpose of treatment. Compared with traditional cancer treatment methods including surgery, chemotherapy and radiotherapy, photodynamic therapy (PDT) has significant advantages such as small trauma...

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Problems solved by technology

[0003] At present, the main problems of photodynamic therapy (PDT) are that most photosensitizers are hydrophobic and have poor solubility in physiological environments, so they are prone to severe agglomeration, which will reduce their photosensitization efficiency and limit Their application in photodynamic therapy (PDT); the second is that UV-visible light is needed to irradiate tissue parts to excite photosensitizer molecules during treatment, while UV-visible light has limited penetration depth to tissues and can only be used in very shallow epidermis and treatment of parts that photons can reach

CNKI Central South University doctoral dissertation titled "The Effect and Mechanism of Hollow Silicon Nanoparticle Photosensitizer in Photodynamic Therapy of Cholangiocarcinoma", introduced a one-step wet chemical method to prepare loaded hollow silicon oxide nanoparticles, and realized the photosensitizer However, they are prone to severe agglomeration, which will reduce their photosensitization efficiency and limit their application in photodynamic therapy.

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