Ferritin photodynamic nanoreactor capable of automatically producing oxygen as well as preparation method and application of ferritin photodynamic nanoreactor

A nano-reactor and ferritin technology, applied in the field of biochemistry, can solve problems such as dependence, achieve stable and controllable performance, high biological safety, and improve therapeutic efficacy

Pending Publication Date: 2022-05-27
UNIV OF SCI & TECH OF CHINA
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Problems solved by technology

However, at present, photodynamic therapy mostly relies on a hyperoxic environment. How to achieve a good therapeutic effect of photosensitizers in tumor hypoxic environments is still a major challenge in the clinical application of photodynamic therapy.

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  • Ferritin photodynamic nanoreactor capable of automatically producing oxygen as well as preparation method and application of ferritin photodynamic nanoreactor
  • Ferritin photodynamic nanoreactor capable of automatically producing oxygen as well as preparation method and application of ferritin photodynamic nanoreactor
  • Ferritin photodynamic nanoreactor capable of automatically producing oxygen as well as preparation method and application of ferritin photodynamic nanoreactor

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Embodiment Construction

[0042] In order to make the objectives, technical solutions and advantages of the present disclosure more clearly understood, the present disclosure will be further described in detail below with reference to specific embodiments and accompanying drawings.

[0043] Photodynamic therapy is that in the presence of oxygen, photosensitizers can generate reactive oxygen species that are toxic to cells after laser irradiation, such as singlet oxygen. Using the oxidative properties of singlet oxygen can destroy the genetic material in cancer cells, resulting in cell damage. apoptosis or death.

[0044] It is well known that the current clinical photodynamic therapy drugs are mostly based on the Type-II photosensitization mechanism, which is highly oxygen-dependent. This results in a very limited therapeutic effect of photodynamic therapy on hypoxic solid tumors. In addition, due to its poor water solubility, fast metabolism, lack of targeting and obvious toxic and side effects, phot...

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Abstract

The invention provides a ferritin photodynamic nano-reactor capable of automatically producing oxygen. The ferritin photodynamic nano-reactor comprises ferritin, a ferritin photodynamic nano-reactor body and a ferritin photodynamic nano-reactor body, the manganese dioxide nanoparticles and the photodynamic photosensitizer are loaded in the inner cavity of the ferritin. The invention further provides application of the ferritin photodynamic nanoreactor capable of automatically producing oxygen to production of active oxygen after illumination. The method comprises the following steps: incubating manganese salt and ferritin, and carrying out biological mineralization to obtain ferritin manganese dioxide nanoparticles; and mixing and stirring a photodynamic photosensitizer dissolved in an organic solvent and the ferritin manganese dioxide nano-particles to obtain the ferritin photodynamic nano-reactor of which the inner cavity is loaded with the photodynamic photosensitizer and manganese dioxide. The manganese dioxide nanoparticles disclosed by the invention have an oxygen self-production effect in a slightly acidic environment so as to improve the photodynamic effect of the photosensitizer.

Description

technical field [0001] The present disclosure belongs to the field of biochemistry, and in particular relates to a self-producing ferritin photodynamic nanoreactor and a preparation method and application thereof. Background technique [0002] Photodynamic therapy refers to the generation of reactive oxygen species (ROS), such as singlet oxygen ( 1 O 2 ), thereby oxidizing surrounding biomolecules, damaging or even killing target cells. Photodynamic therapy has precise spatiotemporal selectivity, obvious therapeutic effect, low toxicity and side effects, and small trauma, and has obvious advantages in the application of tumor therapy. However, at present, photodynamic therapy mostly relies on hyperoxia environment. How to realize the good therapeutic effect of photosensitizers in tumor hypoxic environment is still a major challenge in clinical application of photodynamic therapy. SUMMARY OF THE INVENTION [0003] In view of the above technical problems, the present disc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/64A61K41/00A61P35/00
CPCA61K47/6949A61K47/644A61K41/0071A61P35/00
Inventor 刘扬中朱阳程珺洁
Owner UNIV OF SCI & TECH OF CHINA
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