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Shape memory polyurethane bone scaffold prepared by gas foaming method and application thereof

A gas foaming, bone scaffolding technology, applied in prosthesis, medical science, tissue regeneration, etc., can solve problems such as infection and adverse patient recovery, and achieve the effects of promoting growth, excellent bone conductivity, and proper porosity

Inactive Publication Date: 2021-08-17
CHENGDU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under normal circumstances, transplanting bone repair materials such as skeletons back into the human body requires a large area of ​​surgery, which may cause infection and is not conducive to the recovery of the patient's body

Method used

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  • Shape memory polyurethane bone scaffold prepared by gas foaming method and application thereof
  • Shape memory polyurethane bone scaffold prepared by gas foaming method and application thereof
  • Shape memory polyurethane bone scaffold prepared by gas foaming method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The shape-memory polyurethane bone scaffold material prepared by the gas foaming method provided in this example is composed of polyethylene glycol and amorphous calcium phosphate / calcium citrate composite powder. The content is 10%, and the rest is polyethylene glycol; the amorphous calcium phosphate is the precursor of hydroxyapatite, the calcium citrate is calcium citrate tetrahydrate, and the molecular weight of the polyethylene glycol is 4000. The specific implementation steps are as follows:

[0030] (1) take polyethylene glycol and amorphous calcium phosphate / calcium citrate with electronic balance;

[0031] (2) Add polyethylene glycol (40g) and amorphous calcium phosphate / calcium citrate (4.4g) with a mass ratio of 90 / 10 in a three-necked flask, add dichloromethane, and stir at 80°C;

[0032] (3) Stir for a certain period of time until the mixture is evenly stirred; the stirring speed is 300r / min;

[0033] (4) After mixing evenly, add 4.8ml of hexamethylene di...

Embodiment 2

[0044] The shape-memory polyurethane bone scaffold material prepared by the gas foaming method provided in this example is composed of polyethylene glycol and amorphous calcium phosphate / calcium citrate composite powder. In terms of mass percentage, the content of amorphous calcium phosphate / calcium citrate composite powder 20%, and the rest is polyethylene glycol; amorphous calcium phosphate is the precursor of hydroxyapatite, calcium citrate is calcium citrate tetrahydrate, and the molecular weight of polyethylene glycol is 4000. The specific implementation steps are as follows:

[0045] (1) take polyethylene glycol and amorphous calcium phosphate / calcium citrate with electronic balance;

[0046] (2) Add polyethylene glycol (40g) and amorphous calcium phosphate / calcium citrate (10g) with a mass ratio of 80 / 20 in a three-necked flask, add dichloromethane, and stir at 80°C;

[0047] (3) Stir for a certain period of time until the mixture is evenly stirred; the stirring speed ...

Embodiment 3

[0055] The shape-memory polyurethane bone scaffold material prepared by the gas foaming method provided in this example is composed of polyethylene glycol and amorphous calcium phosphate / calcium citrate composite powder. In terms of mass percentage, the content of amorphous calcium phosphate / calcium citrate composite powder 30%, and the rest is polyethylene glycol; amorphous calcium phosphate is the precursor of hydroxyapatite, calcium citrate is calcium citrate tetrahydrate, and the molecular weight of polyethylene glycol is 4000. The specific implementation steps are as follows:

[0056] (1) take polyethylene glycol and amorphous calcium phosphate / calcium citrate with electronic balance;

[0057] (2) Add polyethylene glycol (40g) and amorphous calcium phosphate / calcium citrate (16.67g) with a mass ratio of 70 / 30 in a three-necked flask, add dichloromethane, and stir at 80°C;

[0058] (3) Stir for a certain period of time until the mixture is evenly stirred; the stirring spe...

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Abstract

The invention belongs to the field of biomedical bone tissue engineering, and particularly relates to a shape memory polyurethane bone scaffold prepared by a gas foaming method and application of the shape memory polyurethane bone scaffold. The invention provides the preparation method of the shape memory polyurethane bone scaffold prepared by using the gas foaming method. According to the invention, hydrophilic polyethylene glycol can provide a good environment for the growth and adhesion of cells and tissue, and can quickly swell in a body fluid environment to accelerate the conversion of the material from a temporary shape to a permanent shape; amorphous calcium phosphate and organic calcium salt, namely calcium citrate cooperate with each other, so calcium supply can be continuously provided for a bone repair material; the shape memory polyurethane bone scaffold prepared by the gas foaming method can be processed into a bone scaffold required for treating bone defects and the like; and the scaffold has good shape memory performance, can complete transformation from a temporary shape to a permanent shape at a temperature close to a physiological temperature, and well meets the requirements of minimally-invasive surgery. The invention provides a feasible and effective novel shape memory polyurethane bone scaffold for the field of biomedical bone tissue engineering.

Description

technical field [0001] The invention relates to a shape-memory polyurethane bone scaffold material prepared by a gas foaming method and an application thereof, belonging to the field of biomedical bone tissue engineering. Background technique [0002] In modern life, due to various accidents or diseases, bone defects are more and more common. Currently, the most common method for treating bone defects is autologous bone grafting. Autologous bone grafting has obvious advantages: no rejection, no pollution, and low material cost. However, the amount of bone obtained from autologous bone grafts is small, so finding an ideal bone repair material that can be mass-produced is the focus of current research. [0003] There are two hydroxyl groups at the end of polyethylene glycol molecular chain, so it has good water absorption. The bone repair material prepared from polyethylene glycol can provide a good environment for the growth of cells in the human body. In addition, polyeth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/12A61L27/50A61L27/58C08G18/48
CPCA61L27/18A61L27/12A61L27/50A61L27/58C08G18/4833A61L2430/02A61L2400/16A61L2300/412C08L71/02C08L75/04
Inventor 王立陈小虎罗昆曾西洋李俊峰张佩聪周世一
Owner CHENGDU UNIVERSITY OF TECHNOLOGY
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