Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of preparation method of hydroxyanthraquinone extracorporeal circulation modified membrane

The technology of hydroxyanthraquinone body and hydroxyanthraquinone, which is applied in the field of medicine, can solve the problem of high hemolysis rate, and achieve the effects of reducing hemolysis reaction, avoiding the risk of organ damage and simple steps.

Active Publication Date: 2022-04-22
XIANGYA HOSPITAL CENT SOUTH UNIV +1
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for preparing a hydroxyanthraquinone extracorporeal circulation modified membrane with simple steps and capable of industrial batch production, so as to solve the technical problem that the hemolysis rate of existing biological materials is too high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of hydroxyanthraquinone extracorporeal circulation modified membrane
  • A kind of preparation method of hydroxyanthraquinone extracorporeal circulation modified membrane
  • A kind of preparation method of hydroxyanthraquinone extracorporeal circulation modified membrane

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] Such as figure 1 As shown, the invention provides a kind of preparation method of hydroxyanthraquinone extracorporeal circulation modified membrane, comprising the following steps:

[0027] S1: Preparation of chloromethylated polysulfone / polyethersulfone / polyester;

[0028] S2: Preparation of aminomethylated polysulfone / polyethersulfone / polyester;

[0029] S3: Preparation of hydroxyanthraquinone modified polysulfone / polyethersulfone / polyester membrane:

[0030] Further, the preparation method of chloromethylated polysulfone / polyethersulfone / polyester in the step S1 is as follows: first dissolve polysulfone / polyethersulfone / polyester in chloroform, then add paraformaldehyde and tetrachloride Fully react the tin oxide to form a complex, then add the chlorine agent trimethylchlorosilane and seal with nitrogen; mix well and put it in a 60°C water bath to complete the stirring reaction for 48-72h; then filter the reactant and wash it with absolute ethanol 3 times; finally...

Embodiment 1

[0034] Step S1: The reaction principle is as follows figure 2 As shown, first dissolve 10g of polysulfone in 250ml of chloroform, then add 0.67g of paraformaldehyde and 0.26ml of tin tetrachloride to fully react to form a complex, then add 11.4ml of chlorine agent trimethylchlorosilane and seal with nitrogen; After mixing evenly, put it in a water bath at 60°C to complete the stirring reaction for 48 hours; then filter the reactant and wash it with absolute ethanol three times; and finally place it in a vacuum oven at 70°C for 24 hours to obtain chloromethylated polysulfone.

[0035] Step S2: The reaction principle is as follows image 3 As shown, dissolve 10g of chloromethylated polysulfone in 100ml of DMF, then pour the prepared phthalimide, DMF solution of chloromethylated polysulfone and sodium hydride mixture into a three-necked flask, wherein The mass volume ratio of phthalimide, DMF solution of chloromethylated polysulfone and sodium hydride is 7.4g: 100ml: 1.2g, heat...

Embodiment 2

[0038] Step S1: Dissolve 10g of polysulfone in 250ml of chloroform, then add 6.7g of paraformaldehyde and 0.52ml of tin tetrachloride to fully react to form a complex, then add 28.5ml of chlorine agent trimethylchlorosilane and nitrogen seal; After mixing evenly, put it in a water bath at 60°C to complete the stirring reaction for 72 hours; then filter the reactant and wash it with absolute ethanol three times; and finally dry it in a vacuum oven at 70°C for 24 hours to obtain chloromethylated polysulfone.

[0039] Step S2: Dissolve 10 g of chloromethylated polysulfone in 100 ml of DMF, then pour the prepared phthalimide, chloromethylated polysulfone in DMF solution and sodium hydride mixture into a three-necked flask, Among them, the mass volume ratio of phthalimide, chloromethylated polysulfone DMF solution and sodium hydride is 7.4g: 100ml: 1.5g, heated to reflux for 12h, cooled to room temperature, and precipitated the product with absolute ethanol , washed in distilled wa...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method of a hydroxyanthraquinone extracorporeal circulation modified membrane. The present invention first chloromethylates polysulfone / polyethersulfone / polyester to prepare chloromethylated polysulfone / polyethersulfone / polyester, then chloromethylates polysulfone / polyethersulfone / polyester with Phthalimide, DMF and sodium hydride are mixed to prepare phthalimide polysulfone / polyethersulfone / polyester, and then phthalimide polysulfone / polyethersulfone / polyester Aminomethylation of ester to obtain aminomethylated polysulfone / polyethersulfone / polyester, and then graft 1,8-dihydroxy-3-carboxyanthraquinone to aminomethylated polysulfone / polyethersulfone / polyester On the ester, obtain hydroxyanthraquinone modified polysulfone / polyethersulfone / polyester, and finally prepare hydroxyanthraquinone modified polysulfone / polyethersulfone / polyester into hydroxyanthraquinone modified polysulfone by immersion precipitation phase inversion method / polyethersulfone / polyester membrane. The method has simple steps, can be used for industrial batch production, and solves the existing technical problem of high hemolysis rate of biological materials.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of a hydroxyanthraquinone extracorporeal circulation modified membrane. Background technique [0002] Extracorporeal circulation therapy, as a life support technology, has been widely used in clinical practice and has become the first choice for the treatment of critically ill patients with acute and chronic organ dysfunction (lung, kidney, liver, etc.), sepsis, severe acute pancreatitis, and septic shock. important treatment method. The contact part between the circulation pipeline and the blood, that is, the membrane-blood interface, is a key part where complications related to artificial materials such as thrombosis and hemolysis occur. Once the above complications occur, they may be life-threatening. At present, most of the research focuses on how to solve the anticoagulant and antithrombotic problems of various modified membranes of extrac...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08J5/18C08L81/06C08L67/00C08G75/20C08G75/23C08G63/91
CPCC08J5/18C08G75/20C08G75/23C08G63/91C08J2381/06C08J2367/00
Inventor 府晓汤赐
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com