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Construction method of kidney transplantation anti-infection drug dosage prediction model

A construction method and dose prediction technology, applied in the construction of the dose prediction model of anti-infective drugs for kidney transplantation, and in the field of dose prediction models for individualized drug regimens of anti-infective drugs for kidney transplantation, which can solve the problem of unclear models and pharmacokinetics of people without kidney transplantation. Kinetics and other issues, to achieve accurate drug treatment, reduce the risk of adverse reactions, and improve the effectiveness of the effect

Active Publication Date: 2021-06-25
ZHEJIANG UNIV
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Problems solved by technology

[0005] Several models of daptomycin have been published, mainly in critically ill patients receiving continuous renal replacement therapy and patients with hematological malignancies, but no pharmacokinetic (PPK) study in the renal transplant population has been performed so far
It is unclear whether the published model can be extrapolated to kidney transplant patients

Method used

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  • Construction method of kidney transplantation anti-infection drug dosage prediction model
  • Construction method of kidney transplantation anti-infection drug dosage prediction model
  • Construction method of kidney transplantation anti-infection drug dosage prediction model

Examples

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Effect test

Embodiment 1

[0060] Example 1 Take daptomycin as an example to illustrate the dose prediction model of anti-infective drugs for kidney transplantation

[0061] Previous studies have found that the pharmacokinetics of daptomycin are characterized by low fat solubility and high plasma protein binding. It is mainly cleared through the kidneys (52%), and the drug is excreted in the urine in its original form. The bactericidal effect of daptomycin is dose-dependent, and its pharmacodynamics is most closely related to the maximum plasma concentration (C max ) to the minimum inhibitory concentration MIC ratio, and the plasma concentration-time curve (AUC 0-24h ) ratio of the area under the MIC. For the treatment of complex skin and soft tissue infections, blood infections, and endocarditis, the FDA recommended dose is 4-6mg / kg / 24h, but if the creatinine clearance rate is less than 30mL / min, the recommended dose is 4-6mg / kg / 48h, but the pharmacokinetic characteristics of different patients vary...

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Abstract

The invention provides a construction method of a kidney transplantation anti-infection drug dosage prediction model. The method comprises the following steps: establishing a group pharmacokinetic model of an anti-infective drug by adopting a nonlinear mixed effect model, a two-atrioventricular model and a mixed residual model through plasma concentration analysis, and calculating pharmacokinetic parameters of the corresponding model; and carrying out related hypothesis testing and estimation on the obtained model pharmacokinetic parameters based on a bootstrap method, visual prediction testing and normalized prediction distribution errors, and completing the steps of stability and prediction capability evaluation and the like. According to the established pharmacokinetic model of the kidney transplantation patient population, the reasonable judgment on the medication scheme information is accurately realized, the reference of the optimal dosage is expected to be provided in the infection prevention and treatment process, the adverse reaction risk is reduced, the curative effect is improved, and finally the individualized administration of the anti-infection medicine of the kidney transplantation patient is realized.

Description

technical field [0001] The invention belongs to the technical field of drug information. More specifically, it relates to a method for constructing a dose prediction model of an anti-infective drug for kidney transplantation, which is a dose prediction model for an individualized dosage regimen of an anti-infective drug for kidney transplantation. Background technique [0002] The current incidence of chronic kidney disease in China is 10.8%, and its prevention and treatment has become a severe public health problem facing the world. Kidney transplantation is a means of renal replacement therapy. Kidney transplantation can significantly improve the living standards of patients with end-stage renal disease. Currently, there are two main problems faced by patients after kidney transplantation: rejection and infection. Anti-infective drugs commonly used in kidney transplant patients include vancomycin and daptomycin. The widespread use of vancomycin has led to the emergence ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H70/40G16C20/50G16C20/70
CPCG16H70/40G16C20/50G16C20/70
Inventor 楼燕洪东升何玲娟杨希
Owner ZHEJIANG UNIV
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