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Hemotrophin and chorionic gonadotrophin composite hormone freeze-dried powder and preparation method thereof

A chorionic gonadotropin and freeze-dried powder technology, which can be used in freeze-dried transportation, sexual diseases, powder transportation, etc., can solve problems such as uneven effects, achieve improved effect, no side effects and safety hazards, and maintain biological activity. and stability effects

Pending Publication Date: 2021-06-01
浙江科瑞特生物科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, in the veterinary drug market, there are many independent blood gonadotropin and chorionic gonadotropin freeze-dried powder products, and the effects are also uneven, mainly due to differences in formulas and freeze-drying processes, but a single blood gonadotropin or Chorionic gonadotropins are not a good solution to reproductive problems in dams or sires
At present, there is no compound hormone product of blood gonadotropin and chorionic gonadotropin in the veterinary drug market

Method used

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  • Hemotrophin and chorionic gonadotrophin composite hormone freeze-dried powder and preparation method thereof

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Effect test

preparation example Construction

[0037] The second aspect of the present invention provides a kind of preparation method of described blood gonadotropin and chorionic gonadotropin composite hormone freeze-dried powder, at least comprising the following steps:

[0038] (1) In a sterile environment, add gonadotropin and chorionic gonadotropin into water at 0-40°C, and stir to obtain mixture A;

[0039] (2) In a sterile environment, add the excipients to the mixture A, and stir to obtain the mixture B;

[0040] (3) In a sterile environment, add a buffer to the mixture B to obtain a mixture C, the pH of the mixture C is 6.8-7.3;

[0041] (4) The mixture C is sterilized and filtered, and then filled, and the product D is obtained after the filling is completed, and the product D is freeze-dried and capped to obtain a packaged compound hormone freeze-dried powder.

[0042] As a preferred technical scheme, the freeze-drying at least includes the following steps:

[0043] (1) Put the product D into a freeze-drying ...

Embodiment 1

[0048] A blood gonadotropin and chorionic gonadotropin composite hormone freeze-dried powder in this embodiment, the preparation raw materials of every 1g blood gonadotropin and chorionic gonadotropin composite hormone freeze-dried powder include: 300IU blood gonadotropin, 100IU chorionic gonadotropin, 20mg stabilizer, 100mg excipient, buffer and water, the chorionic gonadotropin was purchased from Ningbo Sansheng Pharmaceutical Co., Ltd., and the chorionic gonadotropin was purchased from Shandong Xinkang Biotechnology Co., Ltd. .

[0049]The stabilizer is lecithin, and the lecithin is purchased from West Asia Reagent, CAS No.: 8002-43-5.

[0050] The excipient is a mixture of mannitol and α-lactose, the mass ratio of mannitol and α-lactose is 3:1, the mannitol is purchased from Aladdin reagent, CAS number: 69-65-8, the α-Lactose was purchased from West Asia Reagents, CAS No.: 5989-81-1.

[0051] The buffer is a mixture of citric acid and sodium salt, the mass ratio of citri...

Embodiment 2

[0063] A blood gonadotropin and chorionic gonadotropin composite hormone freeze-dried powder in this embodiment, the preparation raw materials of every 1g blood gonadotropin and chorionic gonadotropin composite hormone freeze-dried powder include: 300IU blood gonadotropin, 100IU chorionic gonadotropin, 20mg stabilizer, 100mg excipient, buffer and water, the chorionic gonadotropin was purchased from Ningbo Sansheng Pharmaceutical Co., Ltd., and the chorionic gonadotropin was purchased from Shandong Xinkang Biotechnology Co., Ltd. .

[0064] The stabilizer is lecithin, and the lecithin is purchased from West Asia Reagent, CAS No.: 8002-43-5.

[0065] The excipient is a mixture of mannitol and α-lactose, the mass ratio of mannitol and α-lactose is 4:1, the mannitol is purchased from Aladdin reagent, CAS No.: 69-65-8, the α-Lactose was purchased from West Asia Reagents, CAS No.: 5989-81-1.

[0066] The buffer is a mixture of citric acid and sodium salt, the mass ratio of citric ...

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Abstract

The invention belongs to the technical field of veterinary drugs, and particularly relates to hematotrophin and chorionic gonadotrophin composite hormone freeze-dried powder and a preparation method thereof. The hematotrophin and chorionic gonadotrophin composite hormone freeze-dried powder is prepared from the following raw materials: hematotrophin, chorionic gonadotrophin, a stabilizer, an excipient, a buffering agent and water. The inventor finds that the hematotrophin and the chorionic gonadotrophin are compounded to have a synergistic effect, and according to the technical scheme, after the hematotrophin and the chorionic gonadotrophin are dissolved and uniformly mixed according to a certain proportion, the biological activity and the stability of the hematotrophin and the chorionic gonadotrophin can be maintained to the maximum extent by adjusting parameters in a freeze drying technology; and the preservation time is prolonged, and no side effect or potential safety hazard exists. Meanwhile, the action effect of the compound hormone is greatly improved, and the breeding problem of female livestock or male livestock is well solved.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a freeze-dried powder of blood gonadotropin and chorionic gonadotropin compound hormone and a preparation method thereof. Background technique [0002] The full name of blood gonadotropin is pregnant horse serum gonadotropin (PMSG), which comes from the cup-shaped structure of the placenta of equine animals. It is the only unique gonadotropin among glycoprotein hormones. It has the activities of two gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), in the same molecule. It can stimulate ovarian growth and increase ovarian weight in female animals. Promote the development of follicles to near maturity, the proliferation of follicular granulosa cells, and the increase of follicular fluid secretion. The synergistic effect of follicle-stimulating hormone and luteinizing hormone can promote the secretion of estrogen from follicular...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/24A61K9/19A61K47/24A61K47/22A61P15/08
CPCA61K38/24A61K9/19A61K47/24A61K47/22A61P15/08
Inventor 岳春梅张世忠陈君德方斌奇王亚佩施明华王国源杜雄伟
Owner 浙江科瑞特生物科技有限公司
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