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Animal vaccine-based polymer adjuvant as well as preparation method and application thereof

A technology for polymers and vaccines, which is used in vaccines, veterinary vaccines, medical preparations with inactive ingredients, etc.

Inactive Publication Date: 2021-05-18
郭志文 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing adjuvants seldom use the combination of vegetable oil and polymer components to prepare animal vaccine adjuvants. valuable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Mix lignin and phenol monooxygenase in phosphate buffer and react at room temperature for 12 hours to obtain it; the concentration of lignin is 40g / L; the dosage of biological 4-dimethylaminopyridine is 500U / L , to prepare modified lignin, and set aside; dissolve L-pimagarol, polyacrylic acid and 4-dimethylaminopyridine in a mixed solution of chloroform and tetrahydrofuran, under a nitrogen environment, the temperature is controlled at 10°C, and ethyl Base-3-carbodiimide hydrochloride was sealed and reacted for 1 hour, then heated up to 40°C, and reacted for 72 hours. After the reaction was completed, the solvent was removed and dialyzed with absolute ethanol to obtain a modified polyacrylic acid copolymer for use; modified lignin and modified polyacrylic acid copolymer at a ratio of 1:2 to make a composite polymer for later use; take raw materials according to the following parts by weight: 49 parts of aqueous solution for injection, 75 parts of soybean oil, 19 parts of...

Embodiment 2

[0028] Mix lignin and phenol monooxygenase in phosphate buffer and react at room temperature for 12 hours to obtain it; the concentration of lignin is 40g / L; the dosage of biological 4-dimethylaminopyridine is 500U / L , to prepare modified lignin, and set aside; dissolve L-pimagarol, polyacrylic acid and 4-dimethylaminopyridine in a mixed solution of chloroform and tetrahydrofuran, under a nitrogen environment, the temperature is controlled at 10°C, and ethyl Base-3-carbodiimide hydrochloride was sealed and reacted for 1 hour, then heated up to 40°C, and reacted for 72 hours. After the reaction was completed, the solvent was removed and dialyzed with absolute ethanol to obtain a modified polyacrylic acid copolymer for use; modified lignin and modified polyacrylic acid copolymer according to the ratio of 1:2 to make a compound polymer for future use; take the raw materials according to the following parts by weight: 38 parts of aqueous solution for injection, 55 parts of soybean ...

Embodiment 3

[0030]Mix lignin and phenol monooxygenase in phosphate buffer and react at room temperature for 12 hours to obtain it; the concentration of lignin is 40g / L; the dosage of biological 4-dimethylaminopyridine is 500U / L , to prepare modified lignin, and set aside; dissolve L-pimagarol, polyacrylic acid and 4-dimethylaminopyridine in a mixed solution of chloroform and tetrahydrofuran, under a nitrogen environment, the temperature is controlled at 10°C, and ethyl Base-3-carbodiimide hydrochloride was sealed and reacted for 1 hour, then heated up to 40°C, and reacted for 72 hours. After the reaction was completed, the solvent was removed and dialyzed with absolute ethanol to obtain a modified polyacrylic acid copolymer for use; modified lignin and modified polyacrylic acid copolymer according to the ratio of 1:2 to make a compound polymer, and set aside; take the raw materials according to the following parts by weight: 47 parts of aqueous solution for injection, 72 parts of soybean o...

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PUM

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Abstract

The invention is applicable to the field of animal vaccines, and provides an animal vaccine-based polymer adjuvant as well as a preparation method and application thereof. The animal vaccine-based polymer adjuvant comprises the following raw materials in parts by weight of 38-49 parts of an aqueous solution for injection, 55-75 parts of vegetable oil for injection, 12-19 parts of a compound polymer, 5-9 parts of an emulsifier, 1-3 parts of an auxiliary agent, 2-8 parts of rehalose dimycolate, 2-5 parts of polyinosinic acid-polycytidylic acid, 2-5 parts of bordetella pertussis, 8-18 parts of a radix scutellariae extract, 2-5 parts of a saffron crocus extract and 1-4 parts of a radix rehmanniae extract. According to the animal vaccine-based polymer adjuvant provided by the embodiment of the invention, modified lignin and modified polyacrylic acid copolymer are compounded in proportion and then added into a system, so that a synergistic interaction effect is achieved, and the prepared adjuvant is stable, efficient and worthy of popularization and application.

Description

technical field [0001] The invention belongs to the field of animal vaccines, and in particular relates to a polymer adjuvant based on animal vaccines, a preparation method and an application thereof. Background technique [0002] An adjuvant refers to a substance that can be applied simultaneously or in advance with an antigen to enhance the body's immune response to the antigen, or to change the type of immune response. Adjuvants play a vital role in vaccines. They can act on both antigens and the body. Appropriate use of adjuvants can regulate or even change the type of antigen-specific humoral and / or cellular immune responses produced by the body’s immune system. Adjuvant The mechanism of action of the agent is consistent with the immune response process of the body. First, antigen-presenting cells are activated, foreign antigens are taken up, processed and presented, and then T cells and B cells are further activated. Through the fine adjustment of the cytokine network,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61K9/08A61K47/32A61K47/30
CPCA61K39/39A61K47/30A61K47/32A61K9/0019A61K9/08A61K2039/55555A61K2039/55588A61K2039/552
Inventor 郭志文孔军周丽伟张娟上官淑贞
Owner 郭志文
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