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Thesium chinense granular preparation and preparation method thereof

A kind of granule preparation, the technology of baleen grass, which is applied in the field of balui granule preparation and its preparation, and can solve the problems of low solubility of flavonoids and the like

Inactive Publication Date: 2021-04-23
HONG KONG JOWA & HUAYUAN GRP CHUZHOU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of this application is to provide a Bairui granule preparation and its preparation method, aiming to solve the problem of low solubility of flavonoids in the Bairui Cao preparation in the prior art

Method used

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  • Thesium chinense granular preparation and preparation method thereof
  • Thesium chinense granular preparation and preparation method thereof
  • Thesium chinense granular preparation and preparation method thereof

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preparation example Construction

[0023] The first aspect of the embodiment of the present application provides a preparation method of Bairui granule preparation, comprising the following steps:

[0024] S01. Provide components of Bairui granule preparations, wherein the Bairui granule preparations include thyme extracts, binders, fillers, and lubricants;

[0025] S02. After the Thyme extract is dried, it is dissolved in an organic solvent to obtain a Thyme extract solution;

[0026] S03. mixing the thyme extract solution with a binder and a lubricant to obtain a first mixed solution;

[0027] S04. Drying the first mixed liquid, performing a first sieving treatment, and obtaining first particles;

[0028] S05. Mix the first granule with the filler, secondly sieve, and dry to obtain the Bairui granule preparation.

[0029] The first aspect of the present application provides the preparation method of Bairui granule preparation, the preparation method reforms the preparation method of traditional granule prep...

Embodiment 1

[0070] Bairui granule preparation and preparation method thereof

[0071] Bairui Granules

[0072] Bairui granule preparation, including the following components:

[0073]

[0074] Wherein, the Thyme officinalis extract comprises the mixture of Thyme officinalis total flavonoids extract, Thyme officinalis polysaccharide extract, and Thyme officinalis alkaloid extract; and, Thyme officinalis total flavonoids extract includes at least one of Thyme officinale I, Thyme offal II, Thyme offal III; Binder is selected from polyvinylpyrrolidone, filler is selected from Lactose, lubricant selected from colloidal silicon dioxide.

[0075] The preparation method of Bairui granule preparation

[0076] Provide the component of the Bai Rui granule preparation that embodiment 1 provides;

[0077] drying the Thyme officinalis extract at 80° C. for 5 hours for drying treatment, and then dissolving it in absolute ethanol to obtain the Thyme officinalis extract solution;

[0078] Mixin...

Embodiment 2

[0082] Bairui granule preparation and preparation method thereof

[0083] Bairui Granules

[0084] Bairui granule preparation, including the following components:

[0085]

[0086] Wherein, the Thyme officinalis extract comprises the mixture of Thyme officinalis total flavonoid extract, Thyme officinalis polysaccharide extract, and Thyme officinalis alkaloid extract; ; And, the total flavonoids extract of Thyme officinalis includes at least one of Thyme officinale I, Thyme officinale II, and Thyme officinale III; the binder is selected from polyvinylpyrrolidone, and the filler is selected from Lactose, lubricant selected from colloidal silicon dioxide.

[0087] The preparation method of Bairui granule preparation

[0088] Provide the component of the Bai Rui granule preparation that embodiment 2 provides;

[0089] drying the Thyme officinalis extract at 85°C for 5.5 hours for drying treatment, and then dissolving it in absolute ethanol to obtain the Thyme officinalis e...

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Abstract

The invention provides a preparation method of a thesium chinense granular preparation, which reforms a preparation method of a traditional granular preparation, comprises the following steps: mixing a thesium chinense extract solution with a binder and a lubricant, granulating by adopting a preparation method of drying treatment, and sieving twice to obtain the thesium chinense granular preparation with excellent properties. The preparation process of spray drying is simple in process and mild in drying, the particle size distribution of the obtained particles is narrow, meanwhile, the active ingredients in the prepared thesium chinense particle preparation solid dispersion are mainly and uniformly dispersed in an amorphous form and have relatively high Gibbs energy, so that the required energy during dissolution is relatively low. The dissolvability of active ingredients such as total flavonoids in the thesium chinense granule preparation can be greatly improved, the using effect is improved, and the application universality of the thesium chinense granule preparation is expanded.

Description

technical field [0001] The application belongs to the technical field of traditional Chinese medicine granules, and in particular relates to a Bairui granule preparation and a preparation method thereof. Background technique [0002] Thyme grass is the whole herb of Thesium chinense Turcaz., a plant of the Sandalaceae family. It is distributed in all provinces in the north and south of my country. Thyme grass was first recorded in "Tujing Materia Medica". It tastes slightly astringent and bitter, and is warm in nature. It is often called "plant antibiotic" and is a commonly used traditional Chinese medicine in my country. It has good antibacterial effect and can invigorate qi and kidney, clear away heat and detoxify. Indications for kidney deficiency lumbago, kidney deficiency dizziness, acute mastitis, acute tonsillitis, pharyngitis, pneumonia, lung abscess, upper respiratory tract infection, lobar pneumonia, various infections, etc. [0003] According to literature recor...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/16A61P31/04A61P1/14A61P13/12A61P1/08A61P25/00A61P15/14A61P11/04A61P11/00A61J3/00
CPCA61J3/00A61K9/1682A61K36/185A61P1/08A61P1/14A61P11/00A61P11/04A61P13/12A61P15/14A61P25/00A61P31/04
Inventor 管悦琴罗雪峰李铁程
Owner HONG KONG JOWA & HUAYUAN GRP CHUZHOU PHARMA CO LTD
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