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Composition for preventing or improving menopausal symptom comprising novel ginsenoside

A composition and symptom technology, applied in the field of novel ginsenosides and compositions containing it, can solve problems such as the increase in the prevalence of breast cancer, and achieve the effect of preventing or improving menopausal symptoms and excellent effects

Pending Publication Date: 2021-03-30
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, based on known estrogen therapy (estrogenic therapy), the prevalence of breast cancer increases due to increased growth and cell division of breast cancer cells. In addition, endometritis, thromboembolism, hypertension, etc. Therefore, it is necessary to develop a health food and medicine derived from natural substances that have little side effects on the human body

Method used

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  • Composition for preventing or improving menopausal symptom comprising novel ginsenoside
  • Composition for preventing or improving menopausal symptom comprising novel ginsenoside
  • Composition for preventing or improving menopausal symptom comprising novel ginsenoside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] [Example 1] Separation of Ginsenosides

[0078] Fractionation

[0079] 5.5 kg of ginseng seeds (Seeds of Panax ginseng) were prepared into a powder form by finely grinding with a mixer, extracted with methanol, and subjected to staged fractionation with n-hexane, ethyl acetate, n-butanol, and the like. Most of the lipids were removed by n-hexane, and then the residual lipids in the ethyl acetate fraction were suspended with a solution of methanol:water=1:1 (v / v), placed in the refrigerator overnight, and then taken In the supernatant, lipids were removed again by using a centrifuge. 2.61 g of the ethyl acetate fraction and 114.64 g of the n-butanol fraction subjected to the above pretreatment were fractionated as follows by using a chromatographic column and HPCCC (High Performance Counter-Current Chromatography, High Performance Counter-Current Chromatography).

[0080] Fractionation of n-Butanol Fractions by Utilizing Chromatographic Columns and HPCCC

[0081] ...

experiment Embodiment 1

[0093] [Experimental Example 1] Comparison of the Activity and Efficacy of Estrogen Receptors 1

[0094] Whether ginsenoside GS#10 obtained from ginseng seeds according to an embodiment of the present invention can regulate estrogen receptor activity was confirmed by performing the following experiment.

[0095] By using the novel ginsenoside GS#10 as an example of the present invention, another existing ginsenoside GS#01 to GS#06 isolated from the extract of ginseng seeds, and The ginseng seed extract was treated with the purchased ERα / β (human) reporter gene detection panel (#IB00421-48P; Indigo Bioscience) for 24 hours, and the activity increase level of estrogen receptor ERα and ERβ was analyzed. Both ERα and ERβ are overexpressed in the cells contained in the #IB00421-48P kit, and contain an ERE-luc reporter gene (ERE-luc reporter gene). When the Examples or Comparative Examples are treated respectively, since the activity of ER increases, ERα and ERβ bind to ERE and ind...

experiment Embodiment 2

[0098] [Experimental Example 2] Breast cancer cell growth activity comparison 2

[0099] In the above-mentioned Experimental Example 1, in the case of 17β-estradiol as the positive control group, the activities of ERα and ERβ both increased. On the contrary, in the case of the novel ginsenoside GS# In the case of 10, the activity of ERβ further increased significantly compared to ERα ( Figure 13 ). When ERα is activated, the growth and cell division of breast cancer cells will increase, thereby increasing the prevalence of breast cancer, and ERβ inhibits the growth of cancer cells by inhibiting the activity of ERα, so when the activity of ERβ relative to ERα increases the rate When it is higher, the likelihood of developing breast cancer, which is a representative side effect of estrogen therapy (estrogenic therapy), is expected to be significantly reduced. Therefore, it was confirmed whether the novel ginsenoside GS#10, which is an example of the present invention, does no...

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Abstract

The present disclosure relates to a composition comprising (20S,24R)-6-O-beta-D-glucopyranosyl(1->2)-beta-D-glucopyranoside-dammar-3-one-20,24-epoxy-6a,12b,25-triol, which is a novel ginsenoside, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof as an active ingredient. The composition has an excellent effect of preventing or improving climacteric symptoms while having a low possibility of developing breast cancer.

Description

technical field [0001] This specification relates to a novel ginsenoside and a composition containing it. [0002] 【Related application】 [0003] This application claims priority to Korean Patent Application No. 10-2019-0119642 filed on September 27, 2019, the entire contents of which are incorporated herein by reference. Background technique [0004] Ginseng (Panax ginseng C.A. Meyer) is a plant belonging to the genus Panax of the Araliaceae family. It is a raw herbal medicine that has been used in Korea, China, and Japan since more than 2,000 years ago. The representative physiologically effective components of ginseng are known to be saponins, polysaccharides, peptides, sitosterol, polyacetylene, and fatty acids, among which the saponins of ginseng are called ginsenosides. The known efficacy and effects of ginseng include effects on the central nervous system, anticarcinogenic effects and anticancer activities, immune function regulation effects, antidiabetic effects, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/258A61P15/12A23L33/105
CPCA61K31/7048A61K36/258A61P15/12A23L33/105A23V2002/00A23V2200/30A23V2250/2124A61K9/0019A61K9/2059A61K9/4866A61K9/1652A61K9/0095A61K9/0056A23L33/10A61P5/30A23L33/125A23V2200/302A61K9/0053A61K9/0014
Inventor 洪勇德郑炫禹
Owner AMOREPACIFIC CORP
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