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Composition for alleviating, preventing or treating female menopausal symptoms, containing, as active ingredient, pinitol, d-chiro-inositol or analog compounds thereof

A technology of chiral inositol and active ingredients, applied in the direction of effective ingredients of hydroxyl compounds, medical preparations containing active ingredients, ether/acetal active ingredients, etc., to achieve the effect of generation and activity increase

Inactive Publication Date: 2019-07-05
韩国迪外天然健康株式会社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hormone therapy has been proven to be one of the most effective treatments for reducing menopausal symptoms, but it is reported that some women are more likely to induce blood clots, heart paralysis, stroke, breast cancer, and gallstone disease

Method used

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  • Composition for alleviating, preventing or treating female menopausal symptoms, containing, as active ingredient, pinitol, d-chiro-inositol or analog compounds thereof
  • Composition for alleviating, preventing or treating female menopausal symptoms, containing, as active ingredient, pinitol, d-chiro-inositol or analog compounds thereof
  • Composition for alleviating, preventing or treating female menopausal symptoms, containing, as active ingredient, pinitol, d-chiro-inositol or analog compounds thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0071] Experimental materials and methods

[0072] 1. Administer pinitol or D-chiro-inositol to rats and prepare blood

[0073] Pinitol and D-chiroinositol were purchased from Biosearch Life (Camino de Purchil, 66.18004 Granada, Spain). Divided into 6-month-old female rats (Sparague-Dawley, SD) (Orient, South Korea) administration of pinitol or D-chiro-inositol experimental group and administration of normal saline control group, each group will be 10 Rats were used in the experiment, and were raised in a breeding room at a temperature of 22±1° C., a humidity of 55±1%, and a light-dark cycle of 12 hours. Free intake of food and water was allowed, and after moving in, it was adapted to the above-mentioned rearing environment for 7 days before being used in the experiment. Once a day, the same dose of saline and pinitol or D-chiro-inositol was orally administered in various concentrations (10 mg / kg, 20 mg / kg or 40 mg / kg), and lasted for 8 weeks. After the last oral administra...

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Abstract

The present invention relates to a use of D-chiro-inositol, pinitol, or analog compounds thereof for preventing or treating female menopausal symptoms. The active ingredient compound of the present invention has an effect of increasing the activity of female hormones by increasing the blood concentration of 17beta-estradiol and lowering the blood concentration of sex hormone-binding globulin. Therefore, the active ingredient compound of the present invention can be developed as a drug or a nutraceutical for preventing, alleviating or treating female menopausal symptoms. The active ingredient of the present invention is derived from a natural product, and thus, unlike an agonist of female sex hormones or chemically synthesized sex hormones, has very few side effects when applied to the human body.

Description

technical field [0001] The present invention relates to a composition for improving, preventing or treating female climacteric symptoms comprising pinitol, D-chiro-inositol or their similar compounds as active ingredients. Background technique [0002] Menopause, also known as menopause, is the period when a woman's menstrual periods stop completely. Menopause occurs when a woman's ovaries age and function less, no longer ovulate and no longer produce estrogen. During menopause, the production of female hormones such as estrogen and progesterone gradually decreases. Menopause usually occurs between the ages of 45 and 55, and some women experience earlier menopause as a result of surgery or early ovarian failure. The most common symptom during menopause is menstrual irregularities. It is understood that about 50% of menopausal women in South Korea experience symptoms of acute estrogen deficiency (such as facial flushing, sweating, etc.). About 20% of women will experience...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/075A61K31/047A23L33/10
CPCA23L33/10A61K31/047A61K31/075A61P15/12A61P5/30A61K2300/00
Inventor 明贤君金洸奎
Owner 韩国迪外天然健康株式会社
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