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Traditional Chinese medicine patch for treating chemotherapy-related diarrhea and preparation method thereof

A traditional Chinese medicine paste and correlation technology, applied in the field of pharmaceutical preparations, can solve problems such as limited effect, dysuria, delayed allergic reaction, etc., and achieve the effect of inhibiting secretion generation and reducing the frequency of diarrhea

Pending Publication Date: 2021-03-26
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Loperamide is used for the treatment of mild diarrhea, but its effect is limited in diarrhea above grade III, and 9~30% of patients do not respond to loperamide. In addition, loperamide can cause gastrointestinal spasms, delayed Allergic reactions, dysuria and other adverse reactions
The curative effect of octreotide in the treatment of chemotherapy-related diarrhea is not ideal, and the incidence of paralytic ileus increases with the increase of the dose, which has a certain risk

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take Wu Hao, five times, and take an oven for 6 hours at 40 ° C. After drying, Wu Hao, five times, smashed, 80 mesh sieve, 1 part of Wuyu powder, 6 pieces of five times, mix well. The appropriate amount of Vaseline was added to the end of the mixed powder, prepared a paste, filled into a pressure-containing anti-seepage pot, and a Chinese medicine patch for treating chemotherapy correlation diarrhea.

Embodiment 2

[0030] Take Wu Hao, a five-fold, and take an oven for 4 hours at 60 ° C. After drying, Wu Hao, five times, smashed, over 200 mesh sieve, 3 copies of Wuyao powder, 2 pieces of five times powder, mix evenly. In the end of the mixed powder, an appropriate amount of Vaseline, lanolin was added, and a confusing material was prepared, filled into a pressure-containing anti-seepage powder, and a Chinese medicine patch for chemotherapy-related diarrhea was obtained.

Embodiment 3

[0032] Take Wu Hao, five times, and take 50 ° C oven for 5 hours. After drying, Wu Hao, the five times, smashed, 500 mesh sieve, 2 parts of Wuyan powder, 4 pieces of five times, mix well. The appropriate amount of Vaseline, lanofelen, spermantone is added to the end of the mixed powder, and the cake is prepared, filled into the anti-seepage pots containing pressure sensitive glue, resulting in a Chinese medicine patch for chemotherapy-related diarrhea.

[0033]In order to further verify the efficacy of the finished product preparation of the present invention, we carry out corresponding clinical trials of the product prepared in Example 3 described above, and will be reported as follows.

[0034] General information

[0035] Case Choice: All 30 cases are hospitalized patients in the hospital in our hospital, including 20 males, 10 females, and average age 67.5.

[0036] Diagnostic criteria:

[0037] (1) After the chemotherapy of patients or chemotherapy, diarrhea caused by chemoth...

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Abstract

The invention relates to a traditional Chinese medicine patch for treating chemotherapy-related diarrhea and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. Aiming at the problems in the prior art, the traditional Chinese medicine patch disclosed by the invention is used for treating chemotherapy-related diarrhea, has the characteristics of quick response, remarkable curative effect and high safety, and is superior to other similar preparations in the prior art. The traditional Chinese medicine patch for treating chemotherapy-related diarrhea isprepared from the following raw medicinal materials in parts by weight of 1-3 parts of fructus evodiae and 2-6 parts of galla chinensis. The formula conforms to the traditional Chinese medicine pathogenesis for treating chemotherapy-related diarrhea, and is scientific. Fructus evodiae is pungent, hot, capable of warming the middle warmer, relieving pain, regulating qi and relieving depression, good in nature, capable of encouraging stomach qi and capable of warming the lower energizer. Therefore, the fructus evodiae can warm the spleen, strengthen yang and stop diarrhea, and is a main medicine for treating spleen-kidney yang deficiency and diarrhea. The medicinal materials, auxiliary materials and packaging materials are low in cost, so that the economic burden of patient treatment can berelieved, and the clinical application and popularization value is high.

Description

Technical field [0001] The present invention relates to a traditional Chinese medicine patch and a preparation method thereof in the treatment of chemotherapy, belonging to the technical field of medical preparation. Background technique [0002] Malignant tumors are a common disease, and its incidence is increasing, which greatly threatens people's lives and health. Chemotherapy is a method of treating tumor cells using chemical drugs to inhibit tumor cells in patients in patients. One of the important means of chemotherapy for malignant tumors. Due to the poor choice of chemotherapeutic drugs, while the normal tissue of the body, the normal tissue of the body is also unavoidable, chemotherapy-related diarrhea is one of the common adverse reactions. It is easy to cause chemotherapy-related diarrhea, which is easy to cause chemotherapy, 5-fluorouracil, O'Solin, Carpentine, doxorubin, methotrexate, cytoside. It alone uses Irkai, clinically severe III to IV chemotherapy correlation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/754A61K9/70A61P1/12A61P35/00A61K35/64
CPCA61K9/7023A61K35/64A61K36/754A61K47/44A61P1/12A61P35/00A61K2300/00
Inventor 曹鹏卞美广赵呈雷
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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