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Preparation method of medical sustained-release gel with microporous structure and cold compress gel for treating dermatitis and eczema

A slow-release gel, microporous structure technology, applied in the field of biomedicine, can solve the problems of long-term use, easy recurrence, short efficacy, etc., and achieve the effects of high frequency of use, difficult recurrence of efficacy, and large toxic and side effects.

Active Publication Date: 2021-02-12
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the general ointment has short efficacy, is difficult to absorb, needs long-term use, and is prone to relapse after curing

Method used

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  • Preparation method of medical sustained-release gel with microporous structure and cold compress gel for treating dermatitis and eczema
  • Preparation method of medical sustained-release gel with microporous structure and cold compress gel for treating dermatitis and eczema
  • Preparation method of medical sustained-release gel with microporous structure and cold compress gel for treating dermatitis and eczema

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]A method for preparing an antipruritic, anti-inflammatory and antibacterial cold compress gel is provided. The specific steps are as follows:

[0033](1) Weigh 0.5 g of polyvinyl pyrrolidone and 0.5 g of polyvinyl alcohol into 50 mL of ultrapure water, heat and stir at 50° C. to completely dissolve, forming a 2% polyvinyl pyrrolidone / polyvinyl alcohol solution.

[0034](2) Weigh 2g of chitosan with high degree of deacetylation, dissolve it in 0.1wt% glacial acetic acid, and stir overnight at room temperature to completely dissolve all the chitosan to form a chitosan solution with a mass percentage of 2%.

[0035](3) Take an appropriate amount of the above-dissolved polyvinylpyrrolidone / polyvinyl alcohol solution, and add an appropriate volume of the chitosan solution dissolved in the above-mentioned method to obtain the mass fraction of polyvinylpyrrolidone / polyethylene and chitosan. The ratios are 100:0, 95:5, 90:10, 85:15, 80:20, 70:30, 60:40 mixed solutions.

[0036](4) Place each of t...

Embodiment 2

[0039]A method for preparing a medical sustained-release gel with a microporous structure is provided. The specific steps are as follows:

[0040](1) Add 0.5 g of polyvinylpyrrolidone into 50 mL of ultrapure water, stir at room temperature until completely dissolved, and form a polyvinylpyrrolidone solution with a mass percentage of 1%.

[0041](2) Weigh 0.2 g of carboxymethyl cellulose sodium (CMC-Na) and dissolve in ultrapure water, add and stir to completely dissolve it at room temperature, to form a 0.2% carboxymethyl cellulose sodium solution.

[0042](3) Take an appropriate amount of the above-dissolved polyvinylpyrrolidone solution, and add an appropriate volume of the sodium carboxymethylcellulose solution dissolved by the above-mentioned method to make the mass ratio of polyvinylpyrrolidone and sodium carboxymethylcellulose 45:55.

[0043](4) Place the above-mentioned mixed solution in a constant temperature oven, heat at 100°C, and dry until the residual solution is 20% of the initial...

Embodiment 3

[0045]A method for preparing a medical sustained-release gel with a microporous structure is provided. The specific steps are as follows:

[0046](1) Add 0.5 g of polyvinylpyrrolidone into 50 mL of ultrapure water, stir at room temperature until completely dissolved, and form a polyvinylpyrrolidone solution with a mass percentage of 1%.

[0047](2) Weigh 0.2g of sodium carboxymethyl cellulose and dissolve it in ultrapure water, add and stir to completely dissolve it at room temperature, form a 0.2% sodium carboxymethyl cellulose solution, and dissolve it. The sodium carboxymethylcellulose solution is added to the polyvinylpyrrolidone solution in a certain volume ratio, and the mixture is evenly mixed. The mass ratio of the polyvinylpyrrolidone to the sodium carboxymethylcellulose is 1:1.

[0048](3) Weigh 0.2g of chitosan with high degree of deacetylation and dissolve it in 0.1wt% glacial acetic acid, stir overnight at room temperature to completely dissolve all the chitosan and form a chito...

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to a preparation method of medical sustained-release gel with a microporous structure and cold compress gel for treating dermatitis and eczema. The preparation method comprises the following steps: mixing a certain amount of a solution A prepared from a synthetic biomedical polymer material and a certainamount of a solution B prepared from a natural polymer material or a natural polymer modified material according to a certain ratio, uniformly mixing, and drying at a certain temperature to form gel,thereby obtaining the medical sustained-release gel with the microporous structure. The medical sustained-release gel with the microporous structure is composed of a natural polymer material or a natural polymer modified material and a synthetic biomedical polymer material, a gel network with a controllable microporous structure is formed through a physical crosslinking method of the gel, and thegel network is breathable and beneficial to sustained release of drugs; The hydrogel has the advantages of good biocompatibility, no toxicity, no stimulation and good biological adhesion.

Description

Technical field[0001]The invention belongs to the technical field of biomedicine, and specifically relates to a preparation method of a medical sustained-release gel with a microporous structure and a cold compress gel for treating dermatitis and eczema.Background technique[0002]Hydrogel is a kind of strong water-absorbing material formed after crosslinking of polymer monomers. It is a kind of polymer material with three-dimensional network structure, which is formed by crosslinking by covalent bond or non-covalent bond. Most of the hydrogels are chemically cross-linked by monomer cross-linking agents, but the disadvantage is that the structure contains a small amount of small molecular monomers and cross-linking agents, which affects the compatibility of the hydrogel. The hydrogel obtained by the physical cross-linking method does not require the addition of additional chemical cross-linking agents, so it has high biocompatibility and bio-safety. Although the commonly used hydrogel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/32A61K47/36A61K47/38A61K31/045A61K31/436A61P17/00A61P17/04A61P17/06
CPCA61K9/06A61K9/0014A61K47/32A61K47/36A61K47/38A61K31/045A61K31/436A61P17/00A61P17/04A61P17/06
Inventor 张先正刘新华牛美婷曾旋
Owner WUHAN UNIV
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