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Ibuprofen sustained-release capsule and preparation method thereof

A slow-release capsule and capsule technology, which can be used in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of difficult and complete drug release, irregular drug release, and increased cost. Achieve the effect of being beneficial to drug protection, high production efficiency, and avoiding high temperature operation

Active Publication Date: 2021-01-26
南京易亨制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hypromellose is used as a matrix sustained-release material, which is prone to problems such as irregular drug release and difficult drug release.
Sieve 16 mesh-26 mesh pellets for capsule filling, the yield is low and the cost is increased

Method used

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  • Ibuprofen sustained-release capsule and preparation method thereof
  • Ibuprofen sustained-release capsule and preparation method thereof
  • Ibuprofen sustained-release capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1) Prescription

[0032]

[0033] 2) Preparation process

[0034] Mix the ethanol solution of ibuprofen and the slow-release carrier ethanol solution of the prescribed amount, the solid content of the ethanol solution is 8%, spray dry, set the inlet air temperature at 95°C, the atomization pressure at 1.4bar, and the spray speed at 8r / min. The outlet air temperature is 52°C. The prepared solid dispersion is added with zinc stearate, mixed evenly, and filled into capsules.

Embodiment 2

[0036] 1) Prescription

[0037]

[0038] 2) Preparation process

[0039] Mix the ethanol solution of ibuprofen and the sustained-release carrier ethanol solution of the prescribed amount, the solid content of the ethanol solution is 8%, spray dry, set the inlet air temperature at 100°C, the atomization pressure at 1.5bar, and the spray speed at 8r / min, The outlet air temperature is 58°C. Add micropowder silica gel to the prepared solid dispersion, mix well, and fill capsules.

Embodiment 3

[0041] 1) Prescription

[0042]

[0043] 2) Preparation process

[0044] Mix the ibuprofen ethanol solution and slow-release carrier ethanol solution of prescription quantity, the solid content of ibuprofen ethanol solution is 8%, the solid content of slow-release carrier ethanol solution is 10%, spray dry, set air inlet temperature 100 ℃, atomization pressure 1.5bar, spray speed 9r / min, air outlet temperature 55℃. Add sodium stearate fumarate to the prepared solid dispersion, mix well, and fill capsules.

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an ibuprofen sustained-release capsule and a preparation method thereof. The capsule is prepared by the following steps: enabling ibuprofen and a sustained-release carrier to be prepared into a solid dispersion by a spray drying method, adding a lubricant, performing mixing and performing filling, wherein preferably, the sustained-release carrier is polyacrylic resin polyethylene glycol. The capsule is good in slow release effect, good in process reproducibility and suitable for large-scaleproduction.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to an ibuprofen sustained-release capsule and a preparation method thereof. Background technique [0002] Ibuprofen is an antipyretic and analgesic, non-steroidal anti-inflammatory drug. This product reduces the synthesis of prostaglandins by inhibiting cyclooxygenase, and produces analgesic and anti-inflammatory effects; it has an antipyretic effect through the hypothalamic thermoregulatory center. Its analgesic effect is 16-32 times greater than that of aspirin, its anti-inflammatory effect is weaker, and its antipyretic effect is similar to that of aspirin but its effect is longer. Ibuprofen is a racemic mixture of S (+) and R (-) enantiomers, chemical name 2-(4-isobutylphenyl) benzoic acid, molecular weight 206.28, and its structural formula is: [0003] [0004] Ibuprofen is a white crystalline powder with a slightly peculiar smell and almos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/38A61K47/32A61K47/10A61K31/192A61P29/00
CPCA61K9/1652A61K9/1635A61K9/1641A61K31/192A61P29/00
Inventor 朱学东陈女贞周礼明封思阳
Owner 南京易亨制药有限公司
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