Flower-shaped lactose loaded curcumin nano dry powder inhalant and preparation method thereof

A dry powder inhaler, curcumin technology, applied in the medical field, can solve the problems of low drug separation efficiency, low drug efficacy and stability, low drug loading capacity, etc. good fluidity

Inactive Publication Date: 2020-11-20
常州道宁医药科技有限公司 +1
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

But at the same time, it is also exposed that the separation efficiency of the drug from the carrier after inhalation administration is low, and the amount of drug deposition that actually reaches the treatment site is small, and the drug loading is low, and the drug efficacy and stability are low.

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  • Flower-shaped lactose loaded curcumin nano dry powder inhalant and preparation method thereof
  • Flower-shaped lactose loaded curcumin nano dry powder inhalant and preparation method thereof
  • Flower-shaped lactose loaded curcumin nano dry powder inhalant and preparation method thereof

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[0043] The specific implementation manners of the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0044] A flower-shaped lactose-loaded curcumin nano-dry powder inhaler and a preparation method thereof described in a preferred embodiment of the present invention, wherein the flower-shaped lactose-loaded curcumin nano-dry powder inhaler is composed of a drug carrier and curcumin solid lipid nanoparticles,

[0045] The flower-shaped lactose-loaded curcumin nano dry powder inhaler has an average particle size of 3.35 μm, a water content of 4.57%, an in vitro effective site deposition of 28.73%, and an emptying rate of 95.17%.

[0046] The drug carrier is flower-shaped lactose;

[0047] The flower-shaped lactose is prepared by reacting lactose monohydrate and citric acid, a...

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Abstract

The invention relates to a flower-shaped lactose loaded curcumin nano dry powder inhalant and a preparation method thereof, and belongs to the technical field of medical treatment. The flower-shaped lactose loaded curcumin nano dry powder inhalant consists of a drug carrier and curcumin solid lipid nanoparticles; the drug carrier is flower-shaped lactose; the flower-shaped lactose is prepared by performing a reaction on lactose monohydrate and citric acid; the flower-shaped lactose has a pore surface area of 30 plus and minus 7m2 / g, a pore volume of 0.7 plus and minus 0.3cm3 / g, a diameter peakvalue of 3.4, 5.6 and 12.4nm and an aerodynamic particle size of 2 to 4mum, and is adjustable in crude powder size; the curcumin solid lipid nanoparticles have an entrapment rate of 87.73%, a drug-loading rate of 7.72%, a particle size of 156.9 plus and minus 2.2nm, a polydispersity coefficient of 0.480 and an average Zeta potential of minus 24.8mV; and the dry powder inhalant is administrated toa respiratory system by a dry powder inhaler.

Description

technical field [0001] The invention relates to a flower-shaped lactose-loaded curcumin nano dry powder inhaler and a preparation method thereof, belonging to the field of medical technology. Background technique [0002] At present, in recent years, with the aggravation of environmental pollution, especially air pollution (PM 2.5 particulate matter), high smoking rate and population aging, the resulting respiratory diseases are killing more and more lives. The 2017 edition of the Global Initiative on Chronic Obstructive Pulmonary Disease (COPD) defines COPD as "an inflammatory disease characterized by airflow limitation that is not fully reversible, usually caused by exposure to noxious particles or gases and / or by abnormalities in the alveoli". The global morbidity is increasing, and it is currently the fourth cause of death in the world. It is predicted to become the fifth cause of disability and become a disease that seriously affects public health. Starting from the pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K9/14A61K47/26A61K31/12A61P11/00
CPCA61K9/0075A61K9/145A61K31/12A61P11/00
Inventor 李楠李旭刘洪斌张志彬张广海何书键洪婷婷谭淞文
Owner 常州道宁医药科技有限公司
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