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Micelle-containing drug-loaded corneal contact lens and preparation method thereof

A technology of corneal contact lenses and micelles, which is applied in the field of medicine, can solve the problems of reducing patient compliance, and achieve the effects of increasing bioavailability, prolonging release time, and increasing residence time

Active Publication Date: 2020-10-30
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This significantly reduces patient compliance for chronic diseases such as glaucoma that require long-term treatment

Method used

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  • Micelle-containing drug-loaded corneal contact lens and preparation method thereof
  • Micelle-containing drug-loaded corneal contact lens and preparation method thereof
  • Micelle-containing drug-loaded corneal contact lens and preparation method thereof

Examples

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preparation example Construction

[0050] The invention relates to a preparation method of a micelle-containing drug-loaded corneal contact lens which can be used for the treatment of glaucoma. Or heat to initiate curing, and after demoulding, immerse in a solvent to remove unreacted monomers to obtain a cross-linked polymer hydrogel contact lens.

[0051] Loading drugs can be adrenoceptor agonists, carbonic anhydrase inhibitors, beta-blockers, prostaglandins, and miotics. Such as timolol and latanoprost, but not limited to said drugs for the treatment of glaucoma, characterized as ophthalmic drugs. The loading can be that each micelle is only loaded with one kind of drug, mixed to obtain mixed micelles of multiple drugs, or one micelle is loaded with multiple drugs at the same time, preferably one micelle is loaded with multiple drugs at the same time. The mentioned loading polymer material can be PEG-PLA, PEG-PLGA, PEG-PCL and other PEGylated polymers capable of forming micelles, but not limited to PEGs, cha...

Embodiment example 1

[0058] Implementation Case 1 Preparation of Micellar-Contained Drug-Loaded Contact Lens

[0059] (1) Preparation of polymer micelles

[0060] Combine timolol, and latanoprost total drug 10mg (1:10) with 30mg PEG 2000 -PLA 2400 The polymer micellar material was dissolved in acetonitrile. A thin uniform film formed on the walls of the flask under vacuum rotary evaporation. Hydrate the homogeneous film in deionized water, rotate moderately at 20-60°C, and then filter through a 0.22 μm. filter to remove large particles.

[0061] (2) Preparation of drug-containing micellar contact lenses

[0062] Weigh 0.9g monomer 2-hydroxyethyl methacrylate, add 0.5g micelles loaded with timolol and latanoprost, add 0.025g ethylene glycol dimethacrylate as crosslinking agent, 0.025 The Darocur 1173 of g was used as an initiator, stirred evenly, and after degassing, it was added to a polypropylene contact lens mold, and cured for 30 minutes under an ultraviolet lamp with a wavelength of 365 n...

Embodiment example 2

[0067] Implementation Case 2 Preparation of Micellar Drug-loaded Contact Lens

[0068] (1) Preparation of polymer micelles

[0069] Timolol, and latanoprost total drug 10 mg (1:10) were dissolved in acetonitrile with 50 mg PEG2000-PLA2400 polymer micellar material. A thin uniform film formed on the walls of the flask under vacuum rotary evaporation. Hydrate the homogeneous film in deionized water, rotate moderately at 20-60°C, and filter through a 0.22 μm. filter to remove large particles.

[0070] (2) Preparation of drug-containing micellar contact lenses

[0071] Weigh 0.9g monomer 2-hydroxyethyl methacrylate, add 0.5g micelles loaded with timolol and latanoprost, add 0.025g ethylene glycol dimethacrylate as crosslinking agent, 0.025 The Darocur 1173 of g was used as an initiator, stirred evenly, and after degassing, it was added to a polypropylene contact lens mold, and cured for 30 minutes under an ultraviolet lamp with a wavelength of 365 nm to obtain a hydrogel contac...

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Abstract

The invention belongs to the technical field of medicines, and relates to a micelle-containing drug-loaded corneal contact lens and a preparation method thereof, in particular to a corneal contact lens formed by cross-linked polymer hydrogel prepared from one or more polymer micelles, polymeric monomers and cross-linked copolymers of drugs for treating glaucoma. According to the invention, a drugis encapsulated in a polymer micelle by a thin-film hydration method, and then the drug-loaded micelle is loaded in the corneal contact lens by a photopolymerization or thermocuring method. Accordingto the drug-loaded corneal contact lens prepared by the invention, the release time of the drug in the drug-loaded corneal contact lens is prolonged and the eye bioavailability of the drug is improvedby utilizing the characteristic that the micelle wraps the drug to prolong the release; and the drug-loaded corneal contact lens is used for treating glaucoma.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a micelle-containing drug-loaded corneal contact lens and a preparation method thereof, in particular to a micelle-containing drug-loaded corneal contact lens obtained by ultraviolet light or heat-induced curing and which can be used for the treatment of glaucoma According to the preparation method thereof, the drug-loaded corneal contact lens can significantly improve the bioavailability and is used for treating glaucoma. Background technique [0002] Glaucoma is a chronic optic neuropathy with an incidence of about 60.5 million people worldwide and 8.5 million people who are blind due to the disease. Glaucoma has become the second leading cause of blindness after cataracts. The World Health Organization estimates that by 2020, the number of cases of blindness due to glaucoma will increase to 12 million. At present, elevated intraocular pressure (IOP) is still recognized as the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/34A61K45/00A61P27/06G02C7/04
CPCA61K9/1075A61K47/34A61K45/00A61P27/06G02C7/04
Inventor 张宇唐星尹湉何海冰苟靖欣许佳文
Owner SHENYANG PHARMA UNIVERSITY
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