Eutectic crystal of lenvatinib and benzoic acid, and preparation method thereof
A technology of lenvatinib and benzoic acid, applied in the field of medicinal chemistry, can solve the problems of limited clinical application, poor water solubility of lenvatinib mesylate, high cost, etc.
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Embodiment 1
[0040] Weigh 600 mg of lenvatinib and 172 mg of benzoic acid, add 4 mL of acetonitrile and 4 mL of water to obtain a suspension, stir the suspension at room temperature for 1 h, filter, and dry the resulting white solid at 50 ° C to obtain lenvatinib and Solid sample of benzoic acid co-crystal, yield 88.2%.
Embodiment 2
[0042] Weigh 60 mg of lenvatinib and 17.2 mg of benzoic acid, add 1 mL of anisole to obtain a suspension, stir the suspension at room temperature for 12 hours, filter, and dry the obtained white solid at 50°C to obtain lenvatinib Solid sample co-crystallized with benzoic acid.
Embodiment 3
[0044] Weigh 60 mg of lenvatinib and 17.2 mg of benzoic acid, add 10 μL of isopropanol, grind for 30 min at a frequency of 20 Hz, and dry the resulting white solid at 40 ° C to obtain a solid sample of lenvatinib and benzoic acid co-crystal.
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