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Preparation method and application of titanium alloy surface iodine-loaded antibacterial coating

An antibacterial coating and titanium alloy technology, applied in the field of pharmaceutical biomaterial preparation, can solve the problems of inability to achieve antibacterial effect, no longer suitable, poor antibacterial performance, etc., achieve high-efficiency and long-lasting antibacterial effect, prevent explosive release, prolong The effect of release time

Active Publication Date: 2020-09-29
ZHEJIANG CANWELL MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, although nano-silver has sufficient bactericidal ability, it is no longer suitable for use as an antibacterial material commonly used by the human body.
[0004] Although some products have iodine antibacterial coating on the surface, their antibacterial performance is poor. The iodine substance is unstable and has explosive release, no sustained release effect, and cannot achieve a lasting antibacterial effect.

Method used

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  • Preparation method and application of titanium alloy surface iodine-loaded antibacterial coating
  • Preparation method and application of titanium alloy surface iodine-loaded antibacterial coating
  • Preparation method and application of titanium alloy surface iodine-loaded antibacterial coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A method for preparing an iodine-carrying antibacterial coating on the surface of a titanium alloy, comprising the following steps:

[0055] (1) Degreasing the titanium alloy to obtain the substrate A;

[0056] (2) Substrate A is sandblasted and polished to a uniform surface to obtain substrate B;

[0057] (3) Substrate B is cleaned with ultrasonic waves to obtain substrate C;

[0058] (4) Pickling the substrate C: firstly, at room temperature, treat it with the pickling solution 1 for 10 seconds; then, at 40° C., treat it with the pickling solution 2 for 3 minutes; obtain the substrate D;

[0059] (5) Washing, rinsing and spraying the substrate D with purified water in sequence to obtain the substrate E;

[0060] (6) Put the substrate E in the micro-arc anodizing working solution, and perform micro-arc anodizing treatment for 10 minutes, with a voltage of 160V, a temperature of 10°C, and a frequency of 300H Z , the duty ratio is 10%, and the substrate F is obtained;...

Embodiment 2

[0081] A method for preparing an iodine-carrying antibacterial coating on the surface of a titanium alloy, comprising the following steps:

[0082] (1) Degreasing the titanium alloy to obtain the substrate A;

[0083] (2) Substrate A is sandblasted and polished to a uniform surface to obtain substrate B;

[0084] (3) Substrate B is cleaned with ultrasonic waves to obtain substrate C;

[0085] (4) Pickling the substrate C: firstly, at room temperature, treat it with pickling solution 1 for 15 seconds; then, treat it with pickling solution 2 at 50° C. for 5 minutes; obtain substrate D;

[0086] (5) Washing, rinsing and spraying the substrate D with purified water in sequence to obtain the substrate E;

[0087] (6) Put the base material E in the micro-arc anodizing working solution, and carry out the micro-arc anodizing treatment for 11 minutes, the voltage is 180V, the temperature is 15°C, and the frequency is 500H Z , the duty ratio is 10%, and the substrate F is obtained; ...

Embodiment 3

[0108] A method for preparing an iodine-carrying antibacterial coating on the surface of a titanium alloy, comprising the following steps:

[0109] (1) Degreasing the titanium alloy to obtain the substrate A;

[0110] (2) Substrate A is sandblasted and polished to a uniform surface to obtain substrate B;

[0111] (3) Substrate B is cleaned with ultrasonic waves to obtain substrate C;

[0112] (4) Pickling the substrate C: firstly, at room temperature, treat it with pickling solution 1 for 20 seconds; then, treat it with pickling solution 2 at 60° C. for 5 minutes; obtain substrate D;

[0113] (5) Washing, rinsing and spraying the substrate D with purified water in sequence to obtain the substrate E;

[0114] (6) Put the substrate E in the working solution of micro-arc anodizing, and perform micro-arc anodizing treatment for 12 minutes, with a voltage of 200V, a temperature of 20°C, and a frequency of 1000H Z , the duty ratio is 10%, and the substrate F is obtained;

[0115] ...

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Abstract

The invention discloses a preparation method and application of a titanium alloy surface iodine-loaded antibacterial coating and belongs to the technical field of preparation of medical and biologicalmaterials. The preparation method comprises the following steps: deoiling, blasting sand and grinding, carrying out ultrasonic washing, washing with acid, washing with water, carrying out micro-arc anodic oxidation treatment, washing with water, carrying out electrophoresis, washing with water and sealing pores. A non-metallic material with an antibacterial effect is deposited in a porous bioactive film layer prepared on the surface of a titanium alloy; the risk of dissolving metal ions in the using process is avoided; the antibacterial coating is semi-closed; the explosive release of the iodine material of the antibacterial coating is prevented; the slow release time of the iodine material is obviously prolonged; a more efficient and lasting antibacterial effect can be achieved; the antibacterial sterilization rate of the in-vitro coating reaches 100%; the bonding strength between the antibacterial coating and a titanium alloy substrate is greater than 53MPa; the antibacterial effects of medical apparatus and instruments are ensured; the bacterial infectious diseases caused by the medical apparatus and instruments are reduced; and the inflammations of implants are reduced.

Description

technical field [0001] The invention relates to the technical field of preparation of medical biological materials, in particular to a preparation method and application of an iodine-carrying antibacterial coating on the surface of a titanium alloy. Background technique [0002] At present, during the implantation process of device products, changes in the local environment of the implanted part may cause bacterial infectious diseases. Since the implanted site generally has no antibacterial ability, the danger of bacterial infection is increased. [0003] In order to avoid the above problems, most of the existing antibacterial treatment on the surface of the device is to inject metal substances into the metal implant and the coating of the device to obtain antibacterial properties. However, the disadvantage is that the chemical stability is not good, and it is easy to cause local inflammation. The metal ions dissolved in the solution may cause biocompatibility problems, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/26C25D13/06C25D13/02A61L31/02A61L31/10A61L31/08C09D139/06C09D7/61C09D5/44C09D5/14
CPCA61L31/022A61L31/082A61L31/10A61L2300/106A61L2300/404A61L2300/602A61L2300/606A61L2400/18A61L2420/02C09D5/14C09D5/4407C09D5/448C25D11/026C25D11/26C25D13/02C25D13/04C08L39/06
Inventor 李玉良王若帆朱伟强杨斌宁杜永杰虞方磊彭伟方亮方明
Owner ZHEJIANG CANWELL MEDICAL DEVICES CO LTD
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