Preparation method and application of nano-pesticide dosage form using non-phospholipid liposome as carrier

Abstract

The present invention provides a nanoscale non-phospholipid liposome as an ideal drug carrier, the preparation method and application in the application of pesticide nano dosage forms, the method utilizes sterol compounds and single-chain alkylated amphiphilic compounds The self-assembly behavior in the buffer solution forms a nanodispersant with uniform size and high stability, which can have different charge properties and pH response functions. According to the differences in hydrophilicity, hydrophobicity, molecular weight, and stability of pesticide molecules, drugs are loaded on liposomes in different drug-loading methods, so as to improve drug stability, improve drug release performance, and enhance drug effects. The present invention uses non-phospholipid liposomes combined with pesticide molecules to prepare pesticide nano dosage forms, which can not only improve drug sustained-release ability, but also have environmental response performance, which is suitable for controlled release in different environments and has good drug stability, The slow and controlled release effect and biological safety have broad application prospects.

Description

technical field [0001] The invention belongs to the technical field of pesticide preparation, and in particular relates to a preparation method and application of a nano-pesticide dosage form using non-phospholipid liposomes as a carrier. Background technique [0002] The liquid product synthesized from the pesticide raw material is crude oil, and the solid product is the original powder, which are collectively referred to as the original drug. Most pesticide technical drugs cannot be used directly due to their high physicochemical properties and high content of active ingredients. In practice, they need to be processed into different formulations. Traditional pesticide formulations include emulsions, emulsifiable concentrates, powders, wettable powders, water preparations, suspensions, etc., which have disadvantages such as high content of organic components, poor dispersibility, and dust drift. To 1% of pesticide residues on target crops, this inefficient way of drug acti...

AI Technical Summary

Problems solved by technology

[0007] Although the above-mentioned known technical information exists in the prior art, how to apply non-phospholipid liposomes in the pesticide drug-carrying system remains to be developed. The effective utilization rate of the known traditional pesticide formulations is low, and the pesticide residues and environmental pollution are also serious. Very serious, water-based, dust-free, slow-controlled release, etc. have become the development direction of new pesticide formulations. As a nano-carrier, non-phospholipid liposomes have shown outstanding performance in environmental stability and slow-controlled release of drugs. Excellent performance, has been applied in the field of medicine

However, unlike the relatively controllable environment of the human body, in agricultural applications, facing an open and changeable environment, there are higher requirements for the environmental stability of the drug, and it is more difficult to deliver the drug to the target.

Images