Sodium alginate microspheres of coenzyme Q10 and preparation method thereof

A sodium alginate and coenzyme technology, applied in the chemical field, can solve the problems of coenzyme Q10 drug loading, encapsulation efficiency and stability, etc., to improve drug loading and encapsulation efficiency, which is conducive to wide application and storage long time effect

Active Publication Date: 2020-06-09
SHANGHAI YUKING WATER SOLUBLE MATERIAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the above technologies, the drug loading, encapsulation efficiency and stability of coenzyme Q10 still need to be improved.

Method used

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  • Sodium alginate microspheres of coenzyme Q10 and preparation method thereof
  • Sodium alginate microspheres of coenzyme Q10 and preparation method thereof
  • Sodium alginate microspheres of coenzyme Q10 and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0047] Embodiment 1, the preparation of the sodium alginate microsphere of coenzyme Q10

[0048] In this embodiment, the sodium alginate microspheres of coenzyme Q10 include the following raw materials in weight percentage: 40 wt% of coenzyme Q10, 30 wt% of cyclodextrin, and 30 wt% of sodium alginate.

[0049] The preparation method of the sodium alginate microspheres of the coenzyme Q10 of the present embodiment comprises the following steps:

[0050](1) Weigh 20g of coenzyme Q10, heat to 50°C to form a coenzyme Q10 melt; weigh 15g of sodium alginate, dissolve it in 200g of water, and heat to 50°C to completely dissolve the sodium alginate to form a sodium alginate solution; Weigh 5g of calcium chloride and dissolve it in 250g of water to form an aqueous solution of calcium chloride; weigh 15g of β-cyclodextrin, add it to 300g of water, put it in a high-speed shearing machine, and heat it to 75°C to make β-cyclodextrin The alcohol is completely dissolved to form an aqueous s...

Embodiment 2

[0055] Embodiment 2, the preparation of the sodium alginate microsphere of coenzyme Q10

[0056] In this embodiment, the sodium alginate microspheres of coenzyme Q10 include the following raw materials in weight percentage: coenzyme Q10 10wt%, cyclodextrin 30wt%, sodium alginate 60wt%.

[0057] The preparation method of the sodium alginate microspheres of the coenzyme Q10 of the present embodiment comprises the following steps:

[0058] (1) Weigh 5g of coenzyme Q10, heat to 50°C to form a coenzyme Q10 melt; weigh 30g of sodium alginate, dissolve it in 300g of water, and heat to 60°C to completely dissolve the sodium alginate to form a sodium alginate solution; Weigh 30g of calcium chloride, dissolve it in 300g of water to form an aqueous solution of calcium chloride; weigh 15g of β-cyclodextrin, add it to 450g of water, put it into a high-speed shearing machine, and heat it to 50°C to make β-cyclodextrin The alcohol is completely dissolved to form an aqueous solution of β-cyc...

Embodiment 3

[0063] Embodiment 3, the preparation of the sodium alginate microsphere of coenzyme Q10

[0064] In this embodiment, the sodium alginate microspheres of coenzyme Q10 include the following raw materials in weight percentage: coenzyme Q10 10wt%, cyclodextrin 60wt%, and sodium alginate 30wt%.

[0065] The preparation method of the sodium alginate microspheres of the coenzyme Q10 of the present embodiment comprises the following steps:

[0066] (1) Weigh 5g of coenzyme Q10, heat to 50°C to form a coenzyme Q10 melt; weigh 15g of sodium alginate, dissolve it in 200g of water, and heat to 50°C to completely dissolve the sodium alginate to form a sodium alginate solution; Weigh 8g of calcium chloride and dissolve it in 350g of water to form an aqueous solution of calcium chloride; weigh 30g of β-cyclodextrin, add it to 500g of water, put it in a high-speed shearing machine, and heat it to 60°C to make β-cyclodextrin The alcohol is completely dissolved to form an aqueous solution of β...

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Abstract

The invention provides a method for preparing coenzyme Q10 microspheres. The method includes the following steps: (1) adding an appropriate amount of sodium alginate aqueous solution to coenzyme Q10 inclusion complex aqueous solution, conducting stirring evenly, and then homogenizing to obtain a homogeneous material; (2) adding the homogeneous material dropwise to calcium chloride aqueous solutionwhile keeping stirring, continuing to stir after dropwise adding, so that the sodium alginate can be fully cross-linked, filtering, washing with water, and drying to obtain the sodium alginate microspheres of coenzyme Q10. In the coenzyme Q10 inclusion complex aqueous solution, inclusion wall material is starch wall material, and the mass ratio of water to the starch wall material is 1: (5-30); and the mass ratio among coenzyme Q10, the starch wall material and sodium alginate is 1: (0.5-10): (0.5-10). The invention also provides the sodium alginate microspheres of coenzyme Q10 prepared by the method. The method of the present invention greatly improves the drug loading capacity and encapsulation rate of the coenzyme Q10, can effectively prevent the coenzyme Q10 from being re-precipitated, and improves slow release effect of the coenzyme Q10.

Description

technical field [0001] The invention belongs to the field of chemistry, and relates to sodium alginate microspheres of coenzyme Q10 and a preparation method thereof. Background technique [0002] Coenzyme Q10, also known as ubiquinone, is a quinone ring compound with a long isoprene side chain. It is yellow to orange-yellow crystalline powder at room temperature, odorless and tasteless, with a melting point of 49-52°C, easily soluble in chloroform, benzene, carbon tetrachloride, soluble in acetone, petroleum ether, ether, slightly soluble in ethanol, insoluble in water. Coenzyme Q10 is an indispensable and important physiological substance in the human body. Its chemical structure determines that it has many important physiological functions in the human body. It is an important transfer substance in life activities and the key to the rate-limiting reaction of the mitochondrial respiratory chain. Substances that play an important role in cellular energy generation and enha...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/122A61K47/36A61K47/69A61P1/02A61P9/00A61P9/12A61P25/02A61P25/16A61P35/00
CPCA61K31/122A61K9/5036A61K47/6949A61P9/00A61P25/02A61P9/12A61P1/02A61P35/00A61P25/16
Inventor 王宇周敬扩朱广东陈占魏亚娜
Owner SHANGHAI YUKING WATER SOLUBLE MATERIAL TECH
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