Method for preparing sodium alginate-iron chlorophyllin sodium microcapsule

A technology of sodium iron chlorophyllin and sodium alginate, which is applied in food preparation, microsphere preparation, microcapsules, etc., can solve the problems of uneven capsule particles, large microcapsule particle size, and limited microcapsule speed, and achieve The effect of overcoming microcapsule adhesion, mass production, and improving stability

Inactive Publication Date: 2011-07-06
TANGSHAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a method to prepare sodium alginate-iron leaf by using sodium alginate as the capsule material, aiming at the defects that the preparation speed of microcapsules is limited by the sharp hole method in the prior art, the particle size of the microcapsules is relatively large, and the capsule particles are uneven. The method of sodium chlorate microcapsules, the method adopts the high-voltage electrostatic field method, and the prepared microcapsules are smooth and uniform in shape

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Preparation of sodium alginate solution

[0020] Add deionized water at about 45-60°C into the beaker, slowly add 10.0g of sodium alginate while stirring, to make it just fully dissolved, and let it stand overnight, so that the water can completely penetrate into the interior of the sodium alginate particles to achieve complete dissolution. Prepare a sodium alginate solution with a concentration of 2.0g / 100mL.

[0021] (2) preparation of sodium iron chlorophyllinate solution

[0022] Weigh 2.50g of sodium ferric chlorophyllinate powder and dissolve it in 100mL of deionized water. After it is completely dissolved, dilute to 250mL to make a 1.0g / 100mL sodium ferric chlorophyllinate solution.

[0023] (3) Mixing of sodium iron chlorophyllin and sodium alginate solution

[0024] Add the wall material and core material according to the volume 1:1, stir to make it evenly mixed, keep the temperature in a constant temperature water bath at 30°C for 30min, and then carry o...

Embodiment 2

[0031] 1) Preparation of sodium alginate solution

[0032] Add deionized water at around 45-60°C into the beaker, slowly add 15.0g of sodium alginate while stirring, to make it just fully dissolved, and let it stand overnight, so that the water can completely penetrate into the interior of the sodium alginate particles to achieve complete dissolution. Prepare a sodium alginate solution with a concentration of 3.0g / 100mL.

[0033] (2) preparation of sodium iron chlorophyllinate solution

[0034] Weigh 5.00g of sodium iron chlorophyllide powder and dissolve it in an appropriate amount of deionized water. After it is completely dissolved, make a 2.0g / 100mL sodium iron chlorophyllide solution.

[0035] (3) Mixing of sodium iron chlorophyllin and sodium alginate solution

[0036] Add the wall material and core material according to the volume 1:1, stir to make it evenly mixed, keep the temperature in a constant temperature water bath at 30°C for 30min, and then carry out homogeni...

Embodiment 3

[0043] (1) Preparation of sodium alginate solution

[0044] Add deionized water at about 45-60°C into the beaker, slowly add 20.0g of sodium alginate while stirring, to make it fully dissolved, and let it stand overnight, so that the water can completely penetrate into the interior of the sodium alginate particles to achieve complete dissolution. Prepare a sodium alginate solution with a concentration of 4.0g / 100mL.

[0045] (2) preparation of sodium iron chlorophyllinate solution

[0046] Weigh 7.50g of sodium iron chlorophyllide powder and dissolve it in an appropriate amount of deionized water. After completely dissolving, make a 3.0g / 100mL sodium iron chlorophyllide solution.

[0047] (3) Mixing of sodium iron chlorophyllin and sodium alginate solution

[0048] Add the wall material and core material according to the volume 1:1, stir to make it evenly mixed, keep the temperature in a constant temperature water bath at 30°C for 30min, and then carry out homogenization.

...

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Abstract

The invention relates to a method for improving the shape of a capsule in the field of food color and medicine health protection, in particular to a method for preparing a sodium alginate-iron chlorophyllin sodium microcapsule. The method comprises the following steps that deionized water is added into a beaker, sodium alginate is added into the beaker slowly and is stirred at the same time, and mixed liquor is left to stand for a night after the sodium alginate is dissolved completely so as to obtain sodium alginate solution; iron chlorophyllin sodium powder is weighed and dissolved in deionized water, and iron chlorophyllin sodium solution is obtained after the iron chlorophyllin sodium powder is dissolved completely; iron chlorophyllin sodium solution and sodium alginate solution are mixed, wall material and core material are added according to the volume of mixed liquor which is then stirred so as to obtain the uniform mixture, and the mixture is kept under constant temperature ina constant temperature water bath kettle and then is homogenized; and calcium chloride solution that is curing agent is prepared. Pelletization is carried out through a high-voltage electrostatic field device, and greenish black finished granulums with round particle shape are obtained. By adopting a high-voltage electrostatic field method, the shape of the microcapsule can be obviously improved,the entrapment rate and the drug-loading rate of the microcapsule and the production efficiency can be improved, and the requirements of the microcapsule for the industrialized production can be wellsatisfied.

Description

technical field [0001] The invention relates to a method for improving capsule shape in the fields of food pigments and medicine and health care, in particular to a method for industrially preparing sodium alginate-sodium iron chlorophyllin microcapsules in large quantities. Background technique [0002] In addition to being used as food coloring, sodium ferric chlorophyllin can also be used as an iron fortifier in medicine. Recent pharmacological studies abroad believe that sodium ferric chlorophyllin has antibacterial, antiviral, antiallergic and tissue regeneration effects. A good complex agent for hematopoietic cells, which has therapeutic effects on leukopenia and various anemias caused by various reasons. Making it into microcapsules can not only enhance its stability, but also achieve the purpose of sustained release, which will further expand its application range. At present, the microcapsules are prepared by the sharp hole method. Due to the limited preparation sp...

Claims

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Application Information

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IPC IPC(8): B01J13/02A61K9/50A61K31/409C09B61/00A23L1/29A23P1/04A23L33/00A23P10/30
Inventor 刘欣刘淑萍刘征原
Owner TANGSHAN NORMAL UNIV
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