Method for preparing sodium alginate-iron chlorophyllin sodium microcapsule

Abstract

The invention relates to a method for improving the shape of a capsule in the field of food color and medicine health protection, in particular to a method for preparing a sodium alginate-iron chlorophyllin sodium microcapsule. The method comprises the following steps that deionized water is added into a beaker, sodium alginate is added into the beaker slowly and is stirred at the same time, and mixed liquor is left to stand for a night after the sodium alginate is dissolved completely so as to obtain sodium alginate solution; iron chlorophyllin sodium powder is weighed and dissolved in deionized water, and iron chlorophyllin sodium solution is obtained after the iron chlorophyllin sodium powder is dissolved completely; iron chlorophyllin sodium solution and sodium alginate solution are mixed, wall material and core material are added according to the volume of mixed liquor which is then stirred so as to obtain the uniform mixture, and the mixture is kept under constant temperature ina constant temperature water bath kettle and then is homogenized; and calcium chloride solution that is curing agent is prepared. Pelletization is carried out through a high-voltage electrostatic field device, and greenish black finished granulums with round particle shape are obtained. By adopting a high-voltage electrostatic field method, the shape of the microcapsule can be obviously improved,the entrapment rate and the drug-loading rate of the microcapsule and the production efficiency can be improved, and the requirements of the microcapsule for the industrialized production can be wellsatisfied.

Description

technical field [0001] The invention relates to a method for improving capsule shape in the fields of food pigments and medicine and health care, in particular to a method for industrially preparing sodium alginate-sodium iron chlorophyllin microcapsules in large quantities. Background technique [0002] In addition to being used as food coloring, sodium ferric chlorophyllin can also be used as an iron fortifier in medicine. Recent pharmacological studies abroad believe that sodium ferric chlorophyllin has antibacterial, antiviral, antiallergic and tissue regeneration effects. A good complex agent for hematopoietic cells, which has therapeutic effects on leukopenia and various anemias caused by various reasons. Making it into microcapsules can not only enhance its stability, but also achieve the purpose of sustained release, which will further expand its application range. At present, the microcapsules are prepared by the sharp hole method. Due to the limited preparation sp...

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a method to prepare sodium alginate-iron leaf by using sodium alginate as the capsule material, aiming at the defects that the preparation speed of microcapsules is limited by the sharp hole method in the prior art, the particle size of the microcapsules is relatively large, and the capsule particles are uneven. The method of sodium chlorate microcapsules, the method adopts the high-voltage electrostatic field method, and the prepared microcapsules are smooth and uniform in shape