Preparation method and application of a zinc-copper supersaturated solid solution vascular stent material

A solid solution, zinc-copper alloy technology, applied in the field of application in the preparation of vascular stents, can solve the problems of different processing procedures and contents, and do not consider the biodegradation characteristics of materials, etc., to promote rapid re-endothelialization, reduce mechanical stimulation, room temperature The effect of high elongation

Active Publication Date: 2021-10-08
SHANDONG RIENTECH MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The present invention is different from search patents. The prior art does not only consider the mechanical properties, but does not consider the biodegradation characteristics of the material. This patent calculates the copper element content of 0.3%~2.3% based on the alloy alloy phase diagram and a large number of calculations, and the alloy content is large. Partial control is below 1%, and the processing procedures and contents are also different

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  • Preparation method and application of a zinc-copper supersaturated solid solution vascular stent material
  • Preparation method and application of a zinc-copper supersaturated solid solution vascular stent material
  • Preparation method and application of a zinc-copper supersaturated solid solution vascular stent material

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Embodiment 1

[0058] A method for preparing a single-phase supersaturated solid solution zinc-copper alloy capillary, comprising the following steps:

[0059] (1) Melt zinc and copper raw materials in a high-purity graphite furnace at a temperature of 650°C. After melting, mechanically stir for 20 minutes, and the mass fraction of copper is 0.8%;

[0060] (2) Cast the molten alloy into an ingot, perform equal channel angular extrusion deformation at 150°C, and extrude 8 times.

[0061] (3) Drilling and turning the ingot made in the process of (2) into a pipe with an outer diameter of 8mm and a wall thickness of 1mm;

[0062] (4) The pipe in step (3) is solution treated at 225°C for 8 hours;

[0063] (5) Rapidly cooling the pipe in step (4) in special quenching oil to obtain a single-phase supersaturated solid solution zinc-copper alloy;

[0064] (6) The single-phase supersaturated solid solution zinc-copper alloy pipe in step (5) is drawn into a capillary, and the grains are refined to ob...

Embodiment 2

[0066] A method for preparing a single-phase supersaturated solid solution zinc-copper alloy capillary, comprising the following steps:

[0067] (1) Melt zinc and copper raw materials in a high-purity graphite furnace at a temperature of 650°C. After melting, mechanically stir for 20 minutes, and the mass fraction of copper is 0.3%;

[0068] (2) Cast the molten alloy into an ingot, perform equal channel angular extrusion deformation at 200°C, and extrude 8 times;

[0069] (3) Drilling and turning the ingot in step (2) into a pipe with an outer diameter of 10 mm and a wall thickness of 3 mm;

[0070] (4) Solid solution treatment of the pipe in step (3) at 120°C for 10 hours;

[0071] (5) rapidly cooling the pipe in step (4) in cold water to obtain a single-phase supersaturated solid solution zinc-copper alloy;

[0072] (6) The single-phase supersaturated solid solution zinc-copper alloy pipe material in step (5) is drawn to form a capillary, and the grains are refined to obta...

Embodiment 3

[0074] A method for preparing a single-phase supersaturated solid solution zinc-copper alloy capillary, comprising the following steps:

[0075] (1) Melt zinc and copper raw materials in a high-purity graphite furnace at a temperature of 650°C. After melting, mechanically stir for 20 minutes, wherein the mass fraction of copper is 2.0%, and use a high-energy ultrasonic probe to process the alloy melt;

[0076] (2) Cast the molten alloy into an ingot, perform equal channel angular extrusion deformation at 200°C, and extrude 10 times;

[0077] (3) Drilling and turning the ingot in step (2) to process it into a pipe with an outer diameter of 15 mm and a wall thickness of 5 mm;

[0078] (4) Solid solution treating the pipe in step (3) at 390°C for 5 hours;

[0079] (5) rapidly cooling the pipe in step (4) in cold water to obtain a single-phase supersaturated solid solution zinc-copper alloy;

[0080] (6) The single-phase supersaturated solid solution zinc-copper alloy pipe in st...

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Abstract

The invention discloses a preparation method of a supersaturated solid solution zinc-copper alloy and its application in the preparation of vascular stents, which belong to the field of metal material technology and biomedical materials. The invention obtains accurate The mass fraction is melted according to a certain mass fraction ratio, stirred or high-energy ultrasonic, cast into an alloy ingot, the alloy ingot is subjected to large plastic deformation, and finally the zinc-copper alloy after severe plastic deformation is subjected to solid solution treatment, and then taken out The microstructure of single-phase supersaturated solid solution can be obtained by rapid quenching and cooling in the medium, and finally the capillary tube made by drawing has fine grains and obvious reduction of the second phase.

Description

technical field [0001] The invention belongs to the field of metal materials and biomedical materials, and mainly relates to a preparation method of a supersaturated solid solution zinc-copper alloy biodegradable metal material and its application in the preparation of vascular stents. Background technique [0002] In recent years, the research on biodegradable metal materials tends to be hot, mainly based on magnesium-based alloys, zinc-based alloys, and iron-based alloys. Zinc degradation products (Zn 2+ ) is non-toxic to the human body, and is one of the essential metal elements for the human body (the intake is about 15mg / day). It participates in the formation of various proteins and more than 300 kinds of enzyme reactions, and Zn 2+ / Zn standard electrode potential is -0.7618V, greater than Mg 2+ / Mg (-2.372V) and less than Fe 2+ / Fe (-0.447V) and Fe 3+ / Fe (-0.037V), which means that the chemical reactivity of zinc is between that of iron and magnesium. Degradatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C1/02C22C18/02C22F1/16A61L27/04A61L27/50B21C1/22B21C23/21B21C29/00B21C31/00
CPCA61L27/047A61L27/507B21C1/22B21C23/217B21C29/003B21C31/00C22C1/02C22C18/02C22F1/002C22F1/165
Inventor 张海军葛均波周超王鲁宁冯相蓺张军伟崔晓珊宋彩霞郭海宏侯文博尹玉霞鲁守涛段翠海刘光石章智李春梅
Owner SHANDONG RIENTECH MEDICAL TECH
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