Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method for ambroxol hydrochloride capsule

A technology of ambroxol hydrochloride and capsules, which is applied in the field of preparation of ambroxol hydrochloride capsules, can solve problems such as uneven capsule quality, poor capsule drug stability, and affecting the stability of raw materials, achieving good stability and fewer types of raw materials , low cost effect

Inactive Publication Date: 2020-05-12
ANHUI PIOM PHARMA
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the above process, ethanol is used as a granulation binder, and drying is required after granulation, which wastes energy and resources, and also affects the stability of raw materials, resulting in poor stability of capsules and uneven quality of capsules

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The present embodiment provides a kind of preparation method of ambroxol hydrochloride capsule, comprises the following steps:

[0023] S1: Weigh 700g of ambroxol hydrochloride, 100g of microcrystalline cellulose, 1000g of pregelatinized starch, 200g of gelatin, 100g of talcum powder and 350g of magnesium stearate according to the proportion;

[0024] S2: Put the above raw materials into the grinder in turn, grind for 20-30 minutes, take out and pass through a 100-mesh sieve, weigh, and set aside;

[0025] S3: Take a stirring tank, add ambroxol hydrochloride, microcrystalline cellulose, pregelatinized starch, gelatin and talcum powder into the stirring tank, adjust the rotation speed to 600-900 rpm, mix for 5-10 minutes, and obtain a mixture ;

[0026] S4: The mixture is dry-pressed and granulated, and passed through a 30-mesh sieve to obtain granules;

[0027] S5: blending the granules with magnesium stearate, and mixing uniformly to obtain a filling; filling the fil...

Embodiment 2

[0029] The present embodiment provides a kind of preparation method of ambroxol hydrochloride capsule, comprises the following steps:

[0030] S1: Weigh 625g of ambroxol hydrochloride, 300g of microcrystalline cellulose, 1500g of pregelatinized starch, 500g of gelatin, 200g of talcum powder and 312g of magnesium stearate according to the proportion;

[0031] S2: Put the above raw materials into the grinder in turn, grind for 20-30 minutes, take out and pass through a 100-mesh sieve, weigh, and set aside;

[0032] S3: Take a stirring tank, add ambroxol hydrochloride, microcrystalline cellulose, pregelatinized starch, gelatin and talcum powder into the stirring tank, adjust the rotation speed to 600-900 rpm, mix for 5-10 minutes, and obtain a mixture ;

[0033] S4: The mixture is dry-pressed and granulated, and passed through a 30-mesh sieve to obtain granules;

[0034] S5: blending the granules with magnesium stearate, and mixing uniformly to obtain a filling; filling the fil...

Embodiment 3

[0036] The present embodiment provides a kind of preparation method of ambroxol hydrochloride capsule, comprises the following steps:

[0037] S1: Weigh 600g of ambroxol hydrochloride, 500g of microcrystalline cellulose, 2000g of pregelatinized starch, 800g of gelatin, 300g of talcum powder and 300g of magnesium stearate according to the proportion;

[0038] S2: Put the above raw materials into the grinder in turn, grind for 20-30 minutes, take out and pass through a 100-mesh sieve, weigh, and set aside;

[0039] S3: Take a stirring tank, add ambroxol hydrochloride, microcrystalline cellulose, pregelatinized starch, gelatin and talcum powder into the stirring tank, adjust the rotation speed to 600-900 rpm, mix for 5-10 minutes, and obtain a mixture ;

[0040] S4: The mixture is dry-pressed and granulated, and passed through a 30-mesh sieve to obtain granules;

[0041] S5: blending the granules with magnesium stearate, and mixing uniformly to obtain a filling; filling the fil...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of medicine preparation, and particularly discloses a preparation method for an ambroxol hydrochloride capsule. The preparation method comprises the following steps of: according to a ratio, weighing ambroxol hydrochloride and other pharmaceutical auxiliary medicines; adding the above raw materials into a grinding machine in sequence, and grinding the above raw materials for 20-30 minutes; taking out the grinded raw materials, screening by a sieve of 100 meshes, and weighing for standby; taking an agitated vessel, and adding the ambroxol hydrochloride and the auxiliary medicines into the agitated vessel; regulating a revolving speed to be 600-900 turns / minute, and mixing for 5-10 minutes to obtain a mixture; carrying out dry pressing granulation on the mixture, screening by a sieve of 30 meshes to obtain granules; blending the granules with magnesium stearate, and evenly mixing to obtain a filler; and filling a capsule with the filler to obtain the ambroxol hydrochloride capsule. According to the preparation method disclosed by the invention, deficiencies in the prior art are overcome, the time of a preparation technology is shortened,the problem of being unstable due to wet granulation can be avoided by dry granulation, meanwhile, the consumption of energy and resources is reduced, and cost is lower.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a preparation method of ambroxol hydrochloride capsules. Background technique [0002] Ambroxol hydrochloride is a new generation of mucus-dissolving agent, which is mainly used clinically to treat acute and chronic respiratory diseases. Secretion, thereby reducing sputum viscosity; at the same time, it can promote the secretion of pulmonary surfactant, increase bronchial ciliary movement, make sputum easy to cough up, achieve significant expectoration, and improve respiratory conditions. Ambroxol hydrochloride was first listed in Germany in the early 1980s, and later in France, Italy, Japan, Spain and many other countries. It is in the forefront of the drug rankings of key hospitals in major cities in my country. [0003] The Chinese patent with the application number CN201710893697.3 discloses a sustained-release ambroxol hydrochloride capsule and a preparation me...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/48A61K47/12A61K47/38A61K47/36A61K47/42A61K47/04A61K31/137A61P11/10A61P11/00
CPCA61K9/1611A61K9/1652A61K9/1658A61K9/4858A61K31/137A61P11/00A61P11/10
Inventor 汝宝江中赞王艳山
Owner ANHUI PIOM PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com