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Nitrogen-rich carbon sphere adsorbent for whole blood perfusion and preparation method thereof

An adsorbent and perfusion technology, which is applied in chemical instruments and methods, suction devices, and other chemical processes, can solve the problems of unsatisfactory removal effect, limited application value, platelet damage, etc., and achieve high safety and high mechanical strength , The effect of high blood compatibility

Pending Publication Date: 2020-05-08
刘云晖
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the direct contact of the porous carbon adsorption material with blood will seriously damage the formed components of blood such as red blood cells, white blood cells, especially platelets, and it is inevitable that particles will fall off and enter the blood stream to form microembolisms. Therefore, plasma perfusion is generally used, and The surface of the porous carbon adsorption material must be coated to improve its biocompatibility, but at the expense of reducing the adsorption performance of the material
In addition, the hemoperfusion porous carbon adsorption material removes some special pathogenic factor protein-bound toxoids (such as indoxyl sulfate, p-cresol sulfate, bilirubin, bile acid, etc.) in the fields of uremic toxins and liver diseases. The effect is not ideal enough, which also limits its application value

Method used

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  • Nitrogen-rich carbon sphere adsorbent for whole blood perfusion and preparation method thereof
  • Nitrogen-rich carbon sphere adsorbent for whole blood perfusion and preparation method thereof
  • Nitrogen-rich carbon sphere adsorbent for whole blood perfusion and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] (1) Suspension polymerization

[0033] Stir 40g styrene, 60g divinylbenzene, 100g acrylonitrile, 160g toluene, 2g azobisisobutyronitrile to form an oil phase; mix 400g water and 2g hydroxypropyl methylcellulose and stir to obtain a water phase; Add the oil phase to the water phase, stir and suspend the reaction at 65°C for 12 hours to remove the porogen in the resin obtained by polymerization to obtain polymerized microspheres;

[0034] (2) Pre-oxidation

[0035] Pre-oxidize the polymeric microspheres obtained in step (1) by heating to 250°C for 2 hours in an air atmosphere to obtain pre-oxidized microspheres;

[0036] (3) Carbonization

[0037] The pre-oxidized microspheres obtained in step (2) are heated to 550°C at a rate of 10°C / min for 2h in a nitrogen atmosphere to obtain a nitrogen-rich carbon ball adsorbent for whole blood perfusion with a particle size of 0.3~1mm .

[0038] Attached figure 1 The optical microscope image and scanning electron microscope image of the nitr...

Embodiment 2

[0054] (1) Suspension polymerization

[0055] 50g methyl methacrylate, 50g divinylbenzene, 150g vinyl pyridine, 200g xylene, 3g azobisisoheptonitrile are stirred to form an oil phase; 800g water and 20g gelatin are mixed and stirred to obtain a water phase; The oil phase is added to the water phase, and the suspension is stirred for 5 hours at 70°C to remove the porogen in the resin obtained by polymerization to obtain polymerized microspheres;

[0056] (2) Pre-oxidation

[0057] The polymerized microspheres obtained in step (1) are heated to 230° C. for pre-oxidation for 2 hours in an air atmosphere to obtain pre-oxidized microspheres;

[0058] (3) Carbonization

[0059] Heat the pre-oxidized microspheres obtained in step (2) to 700°C at 8°C / min in an argon atmosphere, and heat-retain and carbonize for 1h to obtain a whole blood perfusion with a particle size of 1~2mm for adsorption by nitrogen-rich carbon balls Agent.

Embodiment 3

[0074] (1) Suspension polymerization

[0075] 30g methyl styrene, 70g 1,6-hexanediol diacrylate, 40g acrylonitrile, 10g vinyl pyridine, 100g ethyl acetate, 1g benzoyl peroxide are stirred to form an oil phase; 350g water and 3.5g Mix the hydroxyethyl cellulose and stir uniformly to obtain the water phase; add the oil phase to the water phase, stir and suspend the reaction at 68° C. for 8 hours to remove the porogen in the resin obtained by polymerization to obtain polymerized microspheres;

[0076] (2) Pre-oxidation

[0077] Pre-oxidize the polymeric microspheres obtained in step (1) by heating to 250°C for 2 hours in an air atmosphere to obtain pre-oxidized microspheres;

[0078] (3) Carbonization

[0079] The pre-oxidized microspheres obtained in step (2) were heated to 600°C at 5°C / min in an argon atmosphere, followed by thermal insulation and carbonization treatment for 3 hours to obtain nitrogen-rich carbon beads for whole blood perfusion with a particle size of 0.1~0.5mm Adsorbe...

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Abstract

The invention provides a nitrogen-rich carbon sphere adsorbent for whole blood perfusion and a preparation method thereof. The adsorbent disclosed by the invention is prepared by carrying out pre-oxidation and carbonization treatment on nitrogen-containing copolymer microspheres with a cross-linked porous structure. The prepared nitrogen-rich carbon sphere adsorbent for whole blood perfusion is good in hydrophilicity, high in blood compatibility and suitable for whole blood perfusion; the prepared nitrogen-rich carbon sphere adsorbent for whole blood perfusion is high in mechanical strength and high in use safety. The prepared nitrogen-rich carbon sphere adsorbent for whole blood perfusion can be applied to the fields of drug poisoning, liver failure, renal failure, immune adsorption and the like, and has relatively high adsorption and removal performance on protein-bound toxoid (such as indol sulfate, p-cresol sulfate, bilirubin, bile acid and the like).

Description

Technical field [0001] The invention relates to an adsorbent for blood purification and a preparation method thereof, in particular to a nitrogen-rich carbon ball adsorbent for whole blood perfusion and a preparation method thereof. Background technique [0002] Hemoperfusion is the use of power to guide the patient's blood to the extracorporeal circulation, and remove the endogenous or exogenous poisons or pathogenic substances in the patient's blood through the adsorbent with special adsorption function in the hemoperfusion device, thereby achieving blood purification. A treatment technique. Since the end of the 1970s, my country has carried out more in-depth research on adsorbents for hemoperfusion, and has been widely used. In particular, fruitful results have been achieved in drug poisoning, liver failure, renal failure, and immunoadsorption. At present, the perfusion adsorbents that have been used in clinics include coated activated carbon, macroporous adsorption resin, c...

Claims

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Application Information

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IPC IPC(8): B01J20/20B01J20/26B01J20/30A61M1/36
CPCA61M1/3621A61M1/3679A61M2202/0413B01J20/20B01J20/264B01J20/28054B01J20/30B01J2220/42B01J2220/46B01J2220/4812A61M2202/0021
Inventor 彭新艳刘云鸿刘云晖
Owner 刘云晖
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