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Zeolite and polyamino acid compounded medical material with hemostasis function and production method and application thereof

A technology of polyamino acid and amino acid, which is applied in the fields of medical formula, application, and medical science, and can solve problems such as inability to effectively promote bone tissue regeneration, zeolite polyamino acid, lack of inorganic components, etc., and achieve excellent application prospects and stable in vitro degradation The effect of good sex and reducing the side effects of exothermic

Inactive Publication Date: 2020-05-08
中鼎凯瑞科技成都有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when polyamino acid materials are used for bone tissue repair, they lack the inorganic components needed for bone tissue repair, because they cannot effectively promote bone tissue regeneration.
[0005] At present, there is no zeolite polyamino acid composite medical material with hemostatic function of the present invention

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1, calcium ion modified Y-type zeolite polyamino acid composite medical material

[0042]1. Modification of Y-type zeolite by calcium ion exchange

[0043] According to the solid-to-liquid ratio of 1g: 10mL, mix Y-type zeolite with 4M calcium chloride solution, stir at 30°C for 8 hours, filter to obtain calcium-assembled Y-type zeolite, wash with deionized water 6 times, until the eluent There is no calcium ion in it, and the modified Y-type zeolite containing calcium ion is obtained by drying.

[0044] 2. Preparation of zeolite amino acid composite medical materials

[0045] Weigh 245.00g ε-aminocaproic acid, 2.30g L-alanine, 8.00g hydroxyproline, 2.80g L-proline, 3.60g L-lysine, 3.10g phenylalanine, add to the flask Add 45mL of water to the flask, stir at a constant speed under a nitrogen atmosphere, slowly raise the temperature to 190°C, add 0.2mL of phosphoric acid solution with a concentration of 7.3mol / L, and react for 8 hours, add 29.42g of the above...

Embodiment 2

[0048] Embodiment 2, strontium ion modified Y-type zeolite polyamino acid composite medical material

[0049] 1. Modification of Y-type zeolite by strontium ion exchange

[0050] Mix Y-type zeolite with 2M strontium chloride solution according to the solid-to-liquid ratio of 1g: 50mL, stir at 30°C for 8h, filter to obtain strontium-assembled Y-type zeolite, wash with deionized water 6 times, until the eluent There is no strontium ion in it, and the modified Y-type zeolite containing strontium ion is obtained by drying.

[0051] 2. Preparation of zeolite amino acid composite medical materials

[0052] Weigh 245.00g ε-aminocaproic acid, 2.30g L-alanine, 8.00g hydroxyproline, 2.80g L-proline, 3.60g L-lysine, 3.10g phenylalanine, add to the flask Add 45mL of water to the flask, stir at a constant speed under a nitrogen atmosphere, slowly raise the temperature to 190°C, add 0.2mL of phosphoric acid solution with a concentration of 7.3mol / L, and react for 8 hours, then add 29.42g ...

Embodiment 3

[0055] Embodiment 3, calcium ion modified Y-type zeolite polyamino acid composite medical material

[0056] 1. Modification of Y-type zeolite by calcium ion exchange

[0057] According to the solid-to-liquid ratio of 1g: 10mL, mix Y-type zeolite with 4M calcium chloride solution, stir at 30°C for 8 hours, filter to obtain calcium-assembled Y-type zeolite, wash with deionized water 6 times, until the eluent There is no calcium ion in it, and the modified Y-type zeolite containing calcium ion is obtained by drying.

[0058] 2. Preparation of zeolite amino acid composite medical materials

[0059] Weigh 130.68g ω-aminoheptanoic acid, 267g L-alanine, 5.24g hydroxyproline, 2.92g L-lysine, 1.65g phenylalanine, add to the flask, add 45mL of water to the flask , stirred at a constant speed under a nitrogen atmosphere, slowly raised the temperature to 190 ° C, added 0.2 mL of phosphoric acid solution with a concentration of 7.3 mol / L, reacted for 4 hours, added 29.42 g of the above-m...

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Abstract

The invention provides a zeolite and polyamino acid compounded medical material with a hemostasis function and a production method and application thereof. The zeolite and polyamino acid compounded medical material with the hemostasis function is formed by subjecting modified zeolite and amino acids to in-situ polymerization; the amino acids are composed of an alpha-amino acid and a non-alpha-amino acid; and a mass ratio of the modified zeolite to the amino acids ranges from 0.05:0.30 to 0.70:0.95. The produced compounded medical material is excellent in mechanical performance and good in in-vitro degradation stability, does not cause damage to tissues after being degraded, has an excellent blood coagulation effect, alleviates the side effect of heat release of zeolite during hemostasis, has good biocompatibility and bioactivity, and can be used as an excellent non-toxic novel biological medical material, especially a bone repair material with a hemostasis function, and when the aminoacids are composed of the alpha-amino acid and the omega-amino acid (non-alpha-amino acid), the performance of the compounded medical material is significantly improved. Moreover, the production method is simple, free from complex technologies and easy to operate, can be subjected to industrial production, and has excellent application prospects.

Description

technical field [0001] The invention relates to biomedical materials, in particular to a zeolite polyamino acid composite medical material with hemostatic function, its preparation method and application. Background technique [0002] The occurrence of traffic accidents, bone diseases and violent behaviors caused by modern vehicles has caused some damage to the supporting structure of the human body—bone tissue. Bone tissue has a certain ability to repair and regenerate, but if the tissue cannot be completely repaired due to the degree of defect and its own factors, implants are needed to restore its function. Therefore, clinically there is a great demand for bone repair materials. Bone repair materials have developed from the initial metal materials to diversification. The supporting bone repair materials currently used in clinical practice are mainly polymers and polymer-based composite materials. However, a large number of studies have shown that both metal materials an...

Claims

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Application Information

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IPC IPC(8): A61L24/02A61L24/04A61L24/00
CPCA61L24/001A61L24/0015A61L24/02A61L24/046A61L2300/102A61L2300/418A61L2400/04C08L77/00
Inventor 严永刚邓光进钟宇戢觅之
Owner 中鼎凯瑞科技成都有限公司
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