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A physiological poison metabolism kinetic model for adults exposed to bisphenol A through mouths

A dynamic model, an adult technology, applied in the field of public health, can solve the problems of uncertainty, inability to promote and apply, and low co-ordination of the population, and achieve the effect of complete structure and accurate health risk.

Inactive Publication Date: 2020-04-21
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Chemicals and their metabolites often show specific toxic effects on biological targets such as specific cells, tissues or organs. Therefore, it is necessary to obtain the "target concentration" of the above-mentioned sites, and it is difficult to affect the internal organs of the human body only by experimental means. or tissue separation and extraction, and because human experiments are too complicated, it is usually necessary to extrapolate based on experimental data of other species (such as rodents), but the differences in physiological structure and function of species make this extrapolation more difficult Uncertainty
Due to the lack of correlation with human physiology, the traditional toxicokinetic model is difficult to accurately predict the internal exposure concentration of chemicals and their metabolites to the target, and it is also difficult to extrapolate the prediction results to different exposure scenarios, exposure routes and species
[0009] At present, the relevant research on bisphenol A is mostly limited to the correlation and mutual derivation between the external exposure dose and the content of bisphenol A in the urine of the population, and the health effects of bisphenol A in the human body depend on the level of unconjugated bisphenol A in the blood As well as the content level of bisphenol A in target organs and target tissues, the actual measurement of this level requires obtaining blood samples from the population and various organs and tissues for testing, and blood sampling is an invasive operation, which is costly and has low cooperation among the population, so it cannot be popularized and applications, and human organs and tissues cannot be sampled and monitored
[0010] Considering that the metabolic parameters of bisphenol A are different in rodents and humans, the physiological toxicokinetic model of bisphenol A applicable to rodents cannot be applied to humans; in addition, bisphenol A metabolism is different in primates and humans. There is no enterohepatic circulation, so it is not advisable to include the human bisphenol A physiological toxicity kinetic model with enterohepatic circulation

Method used

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  • A physiological poison metabolism kinetic model for adults exposed to bisphenol A through mouths
  • A physiological poison metabolism kinetic model for adults exposed to bisphenol A through mouths
  • A physiological poison metabolism kinetic model for adults exposed to bisphenol A through mouths

Examples

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Embodiment 1

[0052] This example discloses a method for constructing a physiological toxicokinetic model of adult oral exposure to bisphenol A, including:

[0053] S1: Determine the kinetics of absorption, distribution, metabolism and excretion of orally ingested BPA in humans;

[0054] S2: Determine the structure of a physiological toxicokinetic model for oral exposure of adults to bisphenol A;

[0055] S3: Establish mathematical models and write differential equations;

[0056] S4: Acquire human physiological parameters, bisphenol A biochemical parameters and bisphenol A toxicokinetic parameters;

[0057] S5: Physiological toxicokinetic model simulation and parameter optimization of bisphenol A;

[0058] S6: After the parameters of the physiological toxicokinetic model of bisphenol A are optimized, the obtained physiological toxicokinetic model of bisphenol A is evaluated.

[0059] For the construction process of the physiological toxicokinetic model of bisphenol A, see figure 1 ,Pro...

Embodiment 2

[0087] This example discloses a physiological toxicokinetic model of adults exposed to bisphenol A, which is obtained according to the construction method described in Example 1. The application of this model is as follows:

[0088] The physiological toxicokinetic model of bisphenol A is used to simulate the scenario of long-term oral intake of bisphenol A by adults: the actual meal situation of the simulated people is taken at 0, 6, and 12 o'clock at 6 o'clock in the morning. Inject one-third of the daily tolerated dose (tolerated daily intake, TDI), each intake lasts about 6 minutes, and then do not ingest for 12-24 hours, and in order to simulate the long-term exposure of human beings to BPA, the model The running time is set to 5*24 hours. The intake used in the model application is 4 μg / kg bw / day (European Union (2018)), and the predicted results are as follows Image 6 and Figure 7 shown. It can be seen that the physiological toxicokinetic model disclosed in this em...

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Abstract

The invention relates to the field of public health, particularly relates to chemical risk assessment, and especially relates to a physiological poison metabolism kinetic model for adults exposed to bisphenol A through mouths. The construction method of the model comprises the following steps: S1, determining a kinetic process of absorption, distribution, metabolism and excretion of the bisphenolA orally taken in a human body; S2, determining a physiological poison metabolism kinetic model structure of the adults exposed to bisphenol A through the mouths; S3, establishing a mathematical model, and compiling a differential equation; S4, acquiring human physiological parameters, bisphenol A biochemical parameters and bisphenol A toxicokinetic parameters; and S5, carrying out simulation andparameter optimization on the physiological poison metabolism kinetic model of the bisphenol A. The model and the method disclosed by the invention are helpful to establish bisphenol A internal and external exposure association of the human body, simulate the content level of bisphenol A in a target organ, and further clarify an effect mechanism and a dose-reaction relationship of the bisphenol Ain combination with an effect index of the bisphenol A, so that the health risk that people are exposed to bisphenol A through the mouths can be evaluated more accurately, and important scientific basic data are provided for making and correcting bisphenol A limit values.

Description

technical field [0001] The invention relates to the field of public health, in particular to chemical risk assessment. In particular, it relates to a physiological toxicokinetic model of adult oral exposure to bisphenol A. Background technique [0002] Bisphenol A (bisphenol A, BPA) (2,2-bis(4-hydroxyphenyl)propane, CAS No. 80-05-7, is a chemical, mainly used in the production of polycarbonate plastics and epoxy Resin monomer, also used in polyester resin, polysulfone resin and polyacrylate resin and flame retardant.Food contact materials, such as baby bottles, tableware, microwave ovens, ovens, food containers, water bottles, milk and beverage bottles, food Polycarbonate is widely used in processing equipment and water pipes, etc. Epoxy resins are used as protective linings in various canned food and beverages, as well as glass jars and bottles, including coatings on metal lids for infant formula containers. Food packaging and BPA added in contact materials will migrate t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B5/00G16H50/50
CPCG16B5/00G16H50/50
Inventor 周颖胡曼何更生
Owner FUDAN UNIV
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