A physiological poison metabolism kinetic model for adults exposed to bisphenol A through mouths
A dynamic model, an adult technology, applied in the field of public health, can solve the problems of uncertainty, inability to promote and apply, and low co-ordination of the population, and achieve the effect of complete structure and accurate health risk.
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Embodiment 1
[0052] This example discloses a method for constructing a physiological toxicokinetic model of adult oral exposure to bisphenol A, including:
[0053] S1: Determine the kinetics of absorption, distribution, metabolism and excretion of orally ingested BPA in humans;
[0054] S2: Determine the structure of a physiological toxicokinetic model for oral exposure of adults to bisphenol A;
[0055] S3: Establish mathematical models and write differential equations;
[0056] S4: Acquire human physiological parameters, bisphenol A biochemical parameters and bisphenol A toxicokinetic parameters;
[0057] S5: Physiological toxicokinetic model simulation and parameter optimization of bisphenol A;
[0058] S6: After the parameters of the physiological toxicokinetic model of bisphenol A are optimized, the obtained physiological toxicokinetic model of bisphenol A is evaluated.
[0059] For the construction process of the physiological toxicokinetic model of bisphenol A, see figure 1 ,Pro...
Embodiment 2
[0087] This example discloses a physiological toxicokinetic model of adults exposed to bisphenol A, which is obtained according to the construction method described in Example 1. The application of this model is as follows:
[0088] The physiological toxicokinetic model of bisphenol A is used to simulate the scenario of long-term oral intake of bisphenol A by adults: the actual meal situation of the simulated people is taken at 0, 6, and 12 o'clock at 6 o'clock in the morning. Inject one-third of the daily tolerated dose (tolerated daily intake, TDI), each intake lasts about 6 minutes, and then do not ingest for 12-24 hours, and in order to simulate the long-term exposure of human beings to BPA, the model The running time is set to 5*24 hours. The intake used in the model application is 4 μg / kg bw / day (European Union (2018)), and the predicted results are as follows Image 6 and Figure 7 shown. It can be seen that the physiological toxicokinetic model disclosed in this em...
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