A kind of simvastatin suspoemulsion and its preparation method and application

Abstract

The invention discloses a simvastatin suspension emulsion and its preparation method and application. Combining the pharmaceutical properties of simvastatin with the preparation process of microcapsule preparations, simvastatin is first prepared into a microcapsule structure with sustained release function, and then mixed with other additives to prepare a suspoemulsion, in which surfactants and emulsifiers make it It has the advantages of both suspension and emulsion, increases the effective dose of simvastatin in the carrier, quickly reaches the target organ after intramuscular injection, maintains the effective blood concentration of the target organ for a long time, and the sustained release function of the microcapsule structure prolongs the half-life of the drug. Improve drug bioavailability, reduce the number of administration, reduce drug side effects, the most important thing is no antibiotic residues, has broad clinical application prospects.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a simvastatin suspension emulsion and its preparation method and application. Background technique [0002] Mastitis is one of the three major diseases that endanger the health of dairy cows. The number of somatic cells in affected cows increases, and the milk production and milk quality decrease. In the past treatment, antibiotics were often used, but improper application and abuse of antibiotics will not only cause milk Drug residues affect milk quality, and can also cause a large number of drug-resistant strains, resulting in failure of follow-up treatment and endangering the health of dairy users. [0003] In the prior art, most of the alternatives to antibiotic treatment methods are traditional Chinese medicine prescriptions, improved Chinese medicine prescriptions, and the development of mastitis vaccines and yolk antibodies to prevent diseases. However, due to the ineffe...

AI Technical Summary

Problems solved by technology

However, due to the good lipophilicity and poor hydrophilicity of simvastatin, the current Pharmacopoeia is limited to tablets and capsules, and its effective dose is low. However, its original powder is directly made into water-soluble injection for intramuscular injection of animals. High toxicity, poor drug absorption, easy to cause adverse reactions, can not meet the needs of factory production and clinical medication