Facial mask capable of being quickly gelatinized and preparation and use method thereof
A gelatinization and facial mask technology, applied in cosmetic preparations, preparations for skin care, cosmetics, etc., can solve the problems of waste of functional components and poor stability, and achieve good fit, system stability, and good biocompatibility. Effect
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Embodiment 1
[0049] The degradation speed and mechanical strength of the fast-gelling facial mask are selected. The present invention needs to select an appropriate degree of cross-linking so that the fast-gelling facial mask can absorb liquid and degrade quickly when used, and then permeate and absorb after being converted into essence. At the same time, it has suitable mechanical strength and flexibility, which is convenient for transportation and has a good user experience.
[0050] 1. Sample preparation:
[0051] (1) Set up 6 experimental groups, add 40g of hyaluronic acid (H-HA) with a molecular weight of 3000kD and 0.4g of Ectoin into purified water, dissolve and mix for 2 hours until the solution is clear and free of visible foreign matter, H- The proportion of solid matter in the HA-Ectoin mixed system is 5%;
[0052] (2) Use NaOH to adjust the pH value of the above mixed system to 10, add 1,4-butanediol diglycidyl ether (BDDE), stir evenly, and cross-link for 6 h at a temperature...
Embodiment 2
[0069] The fast-gelling mask can quickly absorb liquid and degrade when used, and is used for moisturizing skin care. Five sets of masks were prepared for skin moisture testing.
[0070] 1. Sample preparation:
[0071] (1) Set up 5 groups of experimental samples, add 20g of hyaluronic acid (H-HA) with a molecular weight of 1000kD and 20g of ectoin (Ectoin) into the phosphate buffer for each group of experimental samples, dissolve and mix for 2 hours until the solution is clear Foreign matter is visible to the naked eye, and the proportion of solid matter in the H-HA-Ectoin mixed system is 0.5%;
[0072] (2) Use NaOH to adjust the pH value of the above mixed system to 12, add 1,4-butanediol diglycidyl ether, stir evenly, cross-link at 20°C for 8 h, and the mass ratio of H-HA to BDDE is 50: 1 (0.4000g BDDE);
[0073] (3) After cross-linking, use phosphate buffer to purify, take 100ml of the purified solution, and when the pH value is 7.5, the purification is complete, and H-HA...
Embodiment 3
[0084] The fast-gelling facial mask of the present invention has a suitable degree of cross-linking, can quickly absorb liquid and degrade when used, and can be transformed into an essence liquid to permeate and absorb. In this example, the rapid gelling facial mask of the present invention is compared with a double-layer porous biodegradable material coated with active molecules disclosed in our patent CN109316623A, and the difference in the state of liquid absorption and transformation between the two is observed.
[0085] 1. Test sample preparation:
[0086] (1) Add 40g of hyaluronic acid (H-HA) with a molecular weight of 1500kD and 40g of Ectoin into purified water, dissolve and mix for 2 hours until the solution is clear and free of visible foreign matter, solids in the H-HA-Ectoin mixed system Quality accounted for 2.5%;
[0087] (2) Use NaOH to adjust the pH value of the mixed system in step (1) to 10, add 1,4-butanediol diglycidyl ether (BDDE), stir evenly, cross-link...
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