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Preparation method and application of graphene-rare earth up-conversion composite nano microspheres

A rare earth up-conversion, nano-microsphere technology, applied in the preparations for in vivo experiments, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc. It is fully reflected and other problems to achieve the effect of improving the up-conversion luminous efficiency, increasing the drug loading and improving the stability.

Active Publication Date: 2019-12-31
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The deep fusion between graphene and functional materials has not been achieved, so the synergistic effect between different materials is difficult to be fully reflected

Method used

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  • Preparation method and application of graphene-rare earth up-conversion composite nano microspheres
  • Preparation method and application of graphene-rare earth up-conversion composite nano microspheres
  • Preparation method and application of graphene-rare earth up-conversion composite nano microspheres

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Embodiment 1

[0046] (1) Preparation of histidine functionalized graphene quantum dots:

[0047] Histidine and functionalized graphene quantum dots were prepared by hydrothermally reacting a mixture of citric acid, histidine, and octadecylamine at 180 °C for 4 h.

[0048] (2) Preparation of graphene quantum dots-rare earth fluoride upconversion composite:

[0049] YCl 3 (7.5 mmol), YbCl 3 (2.0 mmol) and ErCl 3 (0.5 mmol) was dissolved in ultrapure water (10 mL), and His / FA / OA-NG aqueous solution (50 mg mL -1 , 100 mL), the resulting precipitate was collected, washed twice with ultrapure water to remove free His / FA / OA-NG, and the graphene-rare earth complex was obtained. Disperse this graphene-rare earth complex in ultrapure water (10 mL), add NaF aqueous solution (1.0 mol L -1 , 120 mL), continued to stir for 60 min, then transferred to a pressure reactor, heated the reaction at 180 °C for 4 h, and cooled to room temperature.

[0050] In order to obtain graphene-rare earth gel nanosph...

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Abstract

The present invention relates to a preparation method and an application of graphene-rare earth up-conversion composite nano microspheres, and belongs to the technical field of nano drug-loaded materials. The method comprises the following steps: firstly, preparing histidine functionalized graphene quantum dots and then preparing a graphene quantum dot-rare earth fluoride up-conversion compound; and conducting loading of medicines and then conducting compounding with photothermal agent gold nanoparticles to prepare the graphene-rare earth up-conversion composite nano microspheres. Effective regulation and control of sizes and shapes of rare earth UCNP are realized by utilizing strong coordination capability of histidine and rare earth ions; up-conversion luminous efficiency of the rare earth UCNP materials is improved by utilizing strong infrared light absorption capability of nano graphene and high-efficiency energy transfer between the rare earth UCNP; and the nano-gold is used for absorbing a visible light part in the up-conversion luminescence to generate heat, so that light-controlled release of the medicines is realized.

Description

technical field [0001] The invention relates to a preparation method and application of graphene-rare earth up-conversion composite nano microspheres, belonging to the technical field of nano drug-loaded materials. Background technique [0002] Lanthanide-doped upconverting nanoparticles (UCNPs) are capable of converting near-infrared excitation light into shorter-wavelength visible or ultraviolet emission. Lanthanide-doped UCNPs have shown great advantages in biomedical and related fields due to their small background fluorescence, good photostability, large anti-Stokes shift, and negligible biotoxicity. However, lanthanide-doped UCNPs are limited by poor stability in aqueous media, difficulty in functional modification, and low upconversion luminescence efficiency. At present, the lanthanide UCNP prepared by the widely used solvothermal method is an oil-soluble material, which usually needs to go through "decarboxylation", "hydrophilic material coating" and "functional mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K47/52A61K47/69A61K41/00A61K9/50A61K47/46A61K31/704A61P35/00
CPCA61K9/5068A61K31/704A61K41/0052A61K49/0019A61K49/005A61K49/0067A61K49/0093A61K47/52A61K47/6929A61P35/00A61K2300/00
Inventor 李瑞怡李在均刘玲
Owner JIANGNAN UNIV
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