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A kind of preparation method and application of o-cloxacillin molecular composite membrane based on click chemical imprinting

A technology of o-cloxacillin and click chemistry, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., can solve the problems of reduced thermal stability requirements of basement membranes, long preparation time of molecularly imprinted membranes, and shortened preparation time. , to achieve the effect of obvious imprinting effect, short polymerization reaction time and strong selectivity

Active Publication Date: 2021-10-12
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the deficiencies in the above-mentioned prior art, the purpose of the present invention is to overcome the technical defects in the prior art, solve the problems of long preparation time, high temperature, and low selectivity of traditional molecularly imprinted membranes, and make the thermal stability of the basement membrane The requirements are greatly reduced, the preparation time is greatly shortened, and the selective separation efficiency of the target molecule (o-cloxacillin) is greatly improved

Method used

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  • A kind of preparation method and application of o-cloxacillin molecular composite membrane based on click chemical imprinting
  • A kind of preparation method and application of o-cloxacillin molecular composite membrane based on click chemical imprinting
  • A kind of preparation method and application of o-cloxacillin molecular composite membrane based on click chemical imprinting

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] S1. Preparation of dopamine-modified PVDF basement membrane:

[0057] Dissolve 5g of PVDF powder and 0.1g of polyvinylpyrrolidone in 25mL of organic solvent N,N-dimethylacetamide, stir at 60°C for 12h to obtain a casting solution, let it stand for 20h, and scrape off 0.05mm of Put the PVDF blank membrane into the dopamine hydrochloride aqueous solution with a concentration of 0.5g / L for phase inversion for 18h, take it out and put it into a tris(hydroxymethyl)aminomethane hydrochloride aqueous solution with a pH value of 8 and a concentration of 1g / L for oscillation 3h, after washing with water and drying, the dopamine-modified PVDF basement membrane was obtained;

[0058] S2. SiO 2 Preparation of modified PVDF hydrophilic membrane:

[0059] First prepare a mixed solution of 30mL ethanol and 5mL water, then add 1mL tetraethyl silicate, then add three pieces of dopamine-modified PVDF basement membrane prepared by S1, shake for 3min, then add 0.5mL ammonia water, shake ...

Embodiment 2

[0072] S1. Preparation of dopamine-modified PVDF basement membrane:

[0073] Dissolve 5g of PVDF powder and 0.1g of polyvinylpyrrolidone in 25mL of organic solvent N,N-dimethylacetamide, stir at 80°C for 24 hours to obtain a casting solution, let it stand for 24 hours, and scrape off 0.05mm of Put the PVDF blank membrane into the dopamine hydrochloride aqueous solution with a concentration of 1g / L for phase inversion for 24h, take it out and put it into a tris(hydroxymethyl)aminomethane hydrochloride aqueous solution with a pH value of 8.5 and a concentration of 1.2g / L for oscillation 9h, after washing with water and drying, the dopamine-modified PVDF basement membrane was obtained;

[0074] S2. SiO 2 Preparation of modified PVDF hydrophilic membrane:

[0075] First prepare a mixed solution of 30mL ethanol and 5mL water, then add 1mL tetraethyl silicate, then add three pieces of dopamine-modified PVDF basement membrane prepared by S1, shake for 5min, then add 0.5mL ammonia w...

Embodiment 3

[0088] S1. Preparation of dopamine-modified PVDF basement membrane:

[0089] Dissolve 5g of PVDF powder and 0.1g of polyvinylpyrrolidone in 25mL of organic solvent N,N-dimethylacetamide, stir at 100°C for 36h to obtain a casting solution, let it stand for 28h, and scrape off 0.05mm of Put the PVDF blank membrane into the dopamine hydrochloride aqueous solution with a concentration of 2g / L for phase inversion for 30h, take it out and put it into a tris(hydroxymethyl)aminomethane hydrochloride aqueous solution with a pH value of 9 and a concentration of 1.4g / L for oscillation 12h, after washing with water and drying, the dopamine-modified PVDF basement membrane was obtained;

[0090] S2. SiO 2 Preparation of modified PVDF hydrophilic membrane:

[0091] First prepare a mixed solution of 30mL ethanol and 5mL water, then add 1mL tetraethyl silicate, then add three pieces of dopamine-modified PVDF basement membrane prepared by S1, shake for 10min, then add 0.5mL ammonia water, sha...

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Abstract

The invention belongs to the technical field of preparation of functional materials, and specifically relates to a preparation method and application of a click chemical imprinted cloxacillin molecular composite membrane; the preparation steps are: using dopamine as a bionic modification material, cloxacillin as a template molecule, α-cloxacillin Methacrylic acid is the functional monomer, pentaerythritol tetrakis(3-mercaptopropionate) is the cross-linking agent, and dipentaerythritol pentyl- / hexyl-acrylic acid is the auxiliary cross-linking agent. Based on the "click chemistry" polymerization method, o-cloxacillin is prepared Molecularly imprinted composite membrane; the cloxacillin molecularly imprinted composite membrane prepared by the present invention effectively solves the existing problems of the existing cloxacillin molecularly imprinted polymers such as difficulty in recycling and easy secondary pollution; Good specific recognition ability and adsorption separation ability.

Description

technical field [0001] The invention belongs to the technical field of preparation of functional materials, and specifically relates to a preparation method and application background technology of a click chemical imprinted cloxacillin molecular composite film Background technique [0002] O-cloxacillin is a β-lactam antibiotic with the characteristics of acid resistance and penicillinase resistance. It has antibacterial activity against Gram-positive cocci and Neisseria. Coccus) enzyme-producing strains have stronger antibacterial activity than oxacillin, and are often used to prevent infection of animal diseases and as growth promoters to improve feed utilization. But the illicit use of ortho-cloxacillin in food animals may pose a potential threat to human health. Many departments such as the World Health Organization, the US Food and Drug Administration and the Ministry of Agriculture of China have banned the abuse of cloxacillin in animal husbandry and aquaculture. The...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D69/12B01D71/34B01D67/00
CPCB01D67/0079B01D69/12B01D71/34
Inventor 孙畅卢健吴易霖董泽清于超秦莹莹孟敏佳李春香闫永胜
Owner JIANGSU UNIV
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