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Anti-avian influenza virus neuraminidase N2 monoclonal antibody and encoding engine and application thereof

A neuraminidase, monoclonal antibody technology, applied in the field of biomedicine

Active Publication Date: 2019-11-22
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, with the widespread use of anti-influenza virus drugs, the side effects of drugs and the problem of viral drug resistance are becoming more and more serious

Method used

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  • Anti-avian influenza virus neuraminidase N2 monoclonal antibody and encoding engine and application thereof
  • Anti-avian influenza virus neuraminidase N2 monoclonal antibody and encoding engine and application thereof
  • Anti-avian influenza virus neuraminidase N2 monoclonal antibody and encoding engine and application thereof

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Embodiment Construction

[0032] Below in conjunction with specific embodiment, further elaborate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the content taught by the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the application.

[0033] 1. Preparation of mouse-derived monoclonal antibody against avian influenza virus neuraminidase N2

[0034] 1.1 Immunization of mice

[0035] BALB / c mice were immunized by intraperitoneal injection of chicken embryo allantoic fluid containing H9N2 influenza virus (A / Chicken / Jiangsu / X1 / 2004(X1), once every two weeks, 0.3 mL each time. The antibody titer was measured 10 days after the third immunization, and the mice were bo...

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Abstract

The invention discloses an anti-avian influenza virus neuraminidase N2 monoclonal antibody and encoding engine and application thereof, and belongs to the technical field of biomedicine. The anti-avian influenza virus neuraminidase N2 monoclonal antibody specifically identifies avian influenza virus neuraminidase protein N2, and has the ability to inhibit neuraminidase activity and neutralize virus. According to the anti-avian influenza virus neuraminidase N2 monoclonal antibody and encoding engine and application thereof, the gene sequence and the amino acid sequence of light-heavy chain variable region of the anti-avian influenza virus neuraminidase N2 monoclonal antibody are further cloned, and the uniqueness of the gene sequence and the amino acid sequence is confirmed. The related monoclonal antibody and the variable region gene and amino acid sequence can be used for diagnosis, therapeutic development and the like of the N2 avian influenza virus, and have wide clinical application value.

Description

technical field [0001] The invention belongs to the field of biomedical technology, and relates to a monoclonal antibody that specifically recognizes avian influenza virus neuraminidase N2, has the function of inhibiting neuraminidase activity and neutralizes the virus, and its light and heavy chain variable region genes and applications . Background technique [0002] Avian influenza is an acute and highly contagious infectious disease with multiple symptoms ranging from respiratory system to severe systemic sepsis in poultry caused by type A influenza virus. The influenza A virus genome is composed of eight segments, including PB2, PB1, PA, HA, NP, NA, M, and NS. Hemagglutinin (HA) and neuraminidase (NA) are glycoproteins located on the surface of the influenza virus envelope, which are important basis for the classification of virus subtypes and strains. At present, it is known that type A influenza virus has 16 HA subtypes (H1~H16) and 10 NA subtypes, and it is easy to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/10C07K16/40C12N15/13A61K39/42A61P31/16G01N33/577G01N33/569
CPCC07K16/1018C07K16/40A61P31/16G01N33/577G01N33/56983C07K2317/76C07K2317/35C07K2317/565C07K2317/56A61K2039/505G01N2333/11
Inventor 秦爱建王飞王亚娟林志娴万志敏钱琨邵红霞叶建强
Owner YANGZHOU UNIV
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